Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition

Single amino acid substitutions of Ag and MHC were used to analyze the fine structure of the influenza hemagglutinin (HA)-derived epitope (HA 307-319) recognized in the context of DR7 molecules by a T cell clone. Putative T cell (HA 308, 310, 311, 313, and 316) and DR (HA 309, 312, and 317) contact...

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Veröffentlicht in:	The Journal of immunology (1950) 1991-04, Vol.146 (7), p.2331-2340
Hauptverfasser:	Krieger, JI, Karr, RW, Grey, HM, Yu, WY, O'Sullivan, D, Batovsky, L, Zheng, ZL, Colon, SM, Gaeta, FC, Sidney, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigen-Presenting Cells - immunology Antigens Antigens, Viral - immunology Binding Sites Biological and medical sciences Clone Cells Epitopes Fundamental and applied biological sciences. Psychology Fundamental immunology Hemagglutinins, Viral - immunology Histocompatibility antigens (hla, h-2 and other systems) HLA-DR Antigens - chemistry HLA-DR Antigens - metabolism Humans Immunity, Cellular In Vitro Techniques Major Histocompatibility Complex Molecular immunology Molecular Sequence Data Orthomyxoviridae - immunology Protein Conformation Structure-Activity Relationship T-Lymphocytes - immunology
Online-Zugang:	Volltext
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