Induction of cytochrome P450IIE1 in the obese overfed rat

Cytochrome P450IIE1 (IIE1) is a microsomal xenobiotic-activating enzyme that is inducible not only by various chemical agents but also by fasting and diabetes. Using a rat model that mimics human obesity, we have found that hepatic IIE1 levels are also increased by this common clinical disorder. Liv...

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Veröffentlicht in:	Molecular pharmacology 1991-03, Vol.39 (3), p.275-280
Hauptverfasser:	RAUCY, J. L, LASKER, J. M, KRANER, J. C, SALAZAR, D. E, LIEBER, C. S, CORCORAN, G. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - metabolism Aniline Hydroxylase - metabolism Animals Biological and medical sciences Cytochrome P-450 CYP2E1 cytochrome P450IIE1 endoplasmic reticulum Energy Intake Enzyme Induction Male Medical sciences Metabolic diseases Microsomes, Liver - enzymology N-Methylaspartate - metabolism Obesity Obesity - enzymology Oxidoreductases, N-Demethylating - biosynthesis Rats Rats, Inbred Strains
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