Histocompatibility Antigen Subtypes in Black Women with Class A1 or Class GB Diabetes Mellitus
ABSTRACT Insulin-dependent diabetes mellitus is associated with an increased frequency of certain histocompatibility antigens located on chromosome six, the most common types being B-8, B-15, DR-3, DR-4, and DR-7. We therefore theorized that screening for these subtypes may allow the identification...
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| Veröffentlicht in: | American journal of perinatology 1991-03, Vol.8 (2), p.106-109 |
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| container_title | American journal of perinatology |
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| creator | Winkler, Carey L. Tucker, J. Martin Hauth, John C. Goldenberg, Robert L. Acton, Ronald T. Barger, Bruce O. Go, Rodney C.P. Bell, David S.H. Perkins, Laura L. Vanichanan, Chotip J. Roseman, Jeffrey M. |
| description | ABSTRACT
Insulin-dependent diabetes mellitus is associated with an increased frequency of certain histocompatibility antigens located on chromosome six, the most common types being B-8, B-15, DR-3, DR-4, and DR-7. We therefore theorized that screening for these subtypes may allow the identification of those women with gestational diabetes who will remain euglycemic on dietary modification (class A
1
) compared with those who will require insulin to achieve euglycemia (class GB). From 1982 to 1987, 228 black women with gestational diabetes were screened for the above histocompatibility antigens. As theorized, certain histocompatibility antigen subtypes were more common in women with class GB gestational diabetes mellitus; DR-2 (41.8% versus 23.7% p = 0.015), B-15 (p = 0.07), and DR-3 (p = 0.08). However, because of the low sensitivity (42%), specificity (75%), and positive predictive value (36%), this test is impractical in the clinical management of women with gestational diabetes mellitus. |
| doi_str_mv | 10.1055/s-2007-999356 |
| format | Article |
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Insulin-dependent diabetes mellitus is associated with an increased frequency of certain histocompatibility antigens located on chromosome six, the most common types being B-8, B-15, DR-3, DR-4, and DR-7. We therefore theorized that screening for these subtypes may allow the identification of those women with gestational diabetes who will remain euglycemic on dietary modification (class A
1
) compared with those who will require insulin to achieve euglycemia (class GB). From 1982 to 1987, 228 black women with gestational diabetes were screened for the above histocompatibility antigens. As theorized, certain histocompatibility antigen subtypes were more common in women with class GB gestational diabetes mellitus; DR-2 (41.8% versus 23.7% p = 0.015), B-15 (p = 0.07), and DR-3 (p = 0.08). However, because of the low sensitivity (42%), specificity (75%), and positive predictive value (36%), this test is impractical in the clinical management of women with gestational diabetes mellitus.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2007-999356</identifier><identifier>PMID: 2006934</identifier><language>eng</language><publisher>United States</publisher><subject>African Continental Ancestry Group ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - immunology ; Diagnosis, Differential ; Female ; HLA Antigens - analysis ; HLA-B Antigens - analysis ; HLA-B15 Antigen ; HLA-B8 Antigen - analysis ; HLA-DR3 Antigen - analysis ; HLA-DR4 Antigen - analysis ; HLA-DR7 Antigen - analysis ; Humans ; ORIGINAL ARTICLE ; Pregnancy ; Pregnancy in Diabetics - diagnosis ; Pregnancy in Diabetics - immunology</subject><ispartof>American journal of perinatology, 1991-03, Vol.8 (2), p.106-109</ispartof><rights>1991 by Thieme Medical Publishers, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-999356.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2007-999356$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2006934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winkler, Carey L.</creatorcontrib><creatorcontrib>Tucker, J. Martin</creatorcontrib><creatorcontrib>Hauth, John C.</creatorcontrib><creatorcontrib>Goldenberg, Robert L.</creatorcontrib><creatorcontrib>Acton, Ronald T.</creatorcontrib><creatorcontrib>Barger, Bruce O.</creatorcontrib><creatorcontrib>Go, Rodney C.P.</creatorcontrib><creatorcontrib>Bell, David S.H.</creatorcontrib><creatorcontrib>Perkins, Laura L.</creatorcontrib><creatorcontrib>Vanichanan, Chotip J.</creatorcontrib><creatorcontrib>Roseman, Jeffrey M.</creatorcontrib><title>Histocompatibility Antigen Subtypes in Black Women with Class A1 or Class GB Diabetes Mellitus</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
Insulin-dependent diabetes mellitus is associated with an increased frequency of certain histocompatibility antigens located on chromosome six, the most common types being B-8, B-15, DR-3, DR-4, and DR-7. We therefore theorized that screening for these subtypes may allow the identification of those women with gestational diabetes who will remain euglycemic on dietary modification (class A
1
) compared with those who will require insulin to achieve euglycemia (class GB). From 1982 to 1987, 228 black women with gestational diabetes were screened for the above histocompatibility antigens. As theorized, certain histocompatibility antigen subtypes were more common in women with class GB gestational diabetes mellitus; DR-2 (41.8% versus 23.7% p = 0.015), B-15 (p = 0.07), and DR-3 (p = 0.08). However, because of the low sensitivity (42%), specificity (75%), and positive predictive value (36%), this test is impractical in the clinical management of women with gestational diabetes mellitus.</description><subject>African Continental Ancestry Group</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - immunology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>HLA Antigens - analysis</subject><subject>HLA-B Antigens - analysis</subject><subject>HLA-B15 Antigen</subject><subject>HLA-B8 Antigen - analysis</subject><subject>HLA-DR3 Antigen - analysis</subject><subject>HLA-DR4 Antigen - analysis</subject><subject>HLA-DR7 Antigen - analysis</subject><subject>Humans</subject><subject>ORIGINAL ARTICLE</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - diagnosis</subject><subject>Pregnancy in Diabetics - immunology</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotULtOwzAUtRColMLIiOSJicB1HNvJ2BZokYoYALFh2cahLnkRO0L9e1y1032ch44OQpcEbgkwdueTFEAkRVFQxo_QmECRJ7nI2TEag6AsIZySU3Tm_QaApDnkIzSKEl7QbIw-l86H1rR1p4LTrnJhi6dNcN-2wa-DDtvOeuwaPKuU-cEfbR3_fy6s8bxS3uMpwW1_2BczfO-UtiEqnm0VrQZ_jk5KVXl7cZgT9P748DZfJquXxdN8ukq6NKMhYQZUmQpllIas5ECpZsA1gZKZMrWp0CyzkLFCZFyIzIh4cU4LW4IBayydoOu9b9e3v4P1QdbOmxhCNbYdvMwhyykIiMSrA3HQtf2SXe9q1W_loZCI3-zxsHa2tnLTDn0Tk0sCcle39DuqkPu66T95Im80</recordid><startdate>19910301</startdate><enddate>19910301</enddate><creator>Winkler, Carey L.</creator><creator>Tucker, J. Martin</creator><creator>Hauth, John C.</creator><creator>Goldenberg, Robert L.</creator><creator>Acton, Ronald T.</creator><creator>Barger, Bruce O.</creator><creator>Go, Rodney C.P.</creator><creator>Bell, David S.H.</creator><creator>Perkins, Laura L.</creator><creator>Vanichanan, Chotip J.</creator><creator>Roseman, Jeffrey M.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19910301</creationdate><title>Histocompatibility Antigen Subtypes in Black Women with Class A1 or Class GB Diabetes Mellitus</title><author>Winkler, Carey L. ; Tucker, J. Martin ; Hauth, John C. ; Goldenberg, Robert L. ; Acton, Ronald T. ; Barger, Bruce O. ; Go, Rodney C.P. ; Bell, David S.H. ; Perkins, Laura L. ; Vanichanan, Chotip J. ; Roseman, Jeffrey M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p243t-5c0af27acab04f6033b506b10f5cf2e27b54e0459746774c74e06639ef0c0ece3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>African Continental Ancestry Group</topic><topic>Diabetes Mellitus, Type 1 - diagnosis</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - immunology</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>HLA Antigens - analysis</topic><topic>HLA-B Antigens - analysis</topic><topic>HLA-B15 Antigen</topic><topic>HLA-B8 Antigen - analysis</topic><topic>HLA-DR3 Antigen - analysis</topic><topic>HLA-DR4 Antigen - analysis</topic><topic>HLA-DR7 Antigen - analysis</topic><topic>Humans</topic><topic>ORIGINAL ARTICLE</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - diagnosis</topic><topic>Pregnancy in Diabetics - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winkler, Carey L.</creatorcontrib><creatorcontrib>Tucker, J. Martin</creatorcontrib><creatorcontrib>Hauth, John C.</creatorcontrib><creatorcontrib>Goldenberg, Robert L.</creatorcontrib><creatorcontrib>Acton, Ronald T.</creatorcontrib><creatorcontrib>Barger, Bruce O.</creatorcontrib><creatorcontrib>Go, Rodney C.P.</creatorcontrib><creatorcontrib>Bell, David S.H.</creatorcontrib><creatorcontrib>Perkins, Laura L.</creatorcontrib><creatorcontrib>Vanichanan, Chotip J.</creatorcontrib><creatorcontrib>Roseman, Jeffrey M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winkler, Carey L.</au><au>Tucker, J. Martin</au><au>Hauth, John C.</au><au>Goldenberg, Robert L.</au><au>Acton, Ronald T.</au><au>Barger, Bruce O.</au><au>Go, Rodney C.P.</au><au>Bell, David S.H.</au><au>Perkins, Laura L.</au><au>Vanichanan, Chotip J.</au><au>Roseman, Jeffrey M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histocompatibility Antigen Subtypes in Black Women with Class A1 or Class GB Diabetes Mellitus</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>1991-03-01</date><risdate>1991</risdate><volume>8</volume><issue>2</issue><spage>106</spage><epage>109</epage><pages>106-109</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><abstract>ABSTRACT
Insulin-dependent diabetes mellitus is associated with an increased frequency of certain histocompatibility antigens located on chromosome six, the most common types being B-8, B-15, DR-3, DR-4, and DR-7. We therefore theorized that screening for these subtypes may allow the identification of those women with gestational diabetes who will remain euglycemic on dietary modification (class A
1
) compared with those who will require insulin to achieve euglycemia (class GB). From 1982 to 1987, 228 black women with gestational diabetes were screened for the above histocompatibility antigens. As theorized, certain histocompatibility antigen subtypes were more common in women with class GB gestational diabetes mellitus; DR-2 (41.8% versus 23.7% p = 0.015), B-15 (p = 0.07), and DR-3 (p = 0.08). However, because of the low sensitivity (42%), specificity (75%), and positive predictive value (36%), this test is impractical in the clinical management of women with gestational diabetes mellitus.</abstract><cop>United States</cop><pmid>2006934</pmid><doi>10.1055/s-2007-999356</doi><tpages>4</tpages></addata></record> |
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| ispartof | American journal of perinatology, 1991-03, Vol.8 (2), p.106-109 |
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| subjects | African Continental Ancestry Group Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - immunology Diagnosis, Differential Female HLA Antigens - analysis HLA-B Antigens - analysis HLA-B15 Antigen HLA-B8 Antigen - analysis HLA-DR3 Antigen - analysis HLA-DR4 Antigen - analysis HLA-DR7 Antigen - analysis Humans ORIGINAL ARTICLE Pregnancy Pregnancy in Diabetics - diagnosis Pregnancy in Diabetics - immunology |
| title | Histocompatibility Antigen Subtypes in Black Women with Class A1 or Class GB Diabetes Mellitus |
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