Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor

Acidic fibroblast growth factor (aFGF) is a broad spectrum mitogen that is stabilized by complexation with heparin and heparan proteoglycans. The monomeric human protein contains 3 reduced cysteine residues of unknown function, the first 2 of which are conserved among all seven known fibroblast grow...

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