A controlled trial of sotalol for 1 year after myocardial infarction
We carried out a double-blind, randomized study, based at The Academic Department of Cardiology in Newcastle upon Tyne, to compare the effect of sotalol 320 mg once daily with that of placebo in patients from 20 hospitals who survived an acute myocardial infarction. Treatment was started 5-14 days a...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1983-06, Vol.67 (6 Pt 2), p.I61-I62 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | I62 |
|---|---|
| container_issue | 6 Pt 2 |
| container_start_page | I61 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 67 |
| creator | Julian, D G Jackson, F S Szekely, P Prescott, R J |
| description | We carried out a double-blind, randomized study, based at The Academic Department of Cardiology in Newcastle upon Tyne, to compare the effect of sotalol 320 mg once daily with that of placebo in patients from 20 hospitals who survived an acute myocardial infarction. Treatment was started 5-14 days after infarction in 1456 patients; 60% were randomized to sotalol and 40% to placebo. This represented 45% of those evaluated for entry. All patients were followed for 12 months and the analysis was done on an "intention-to-treat" principle. Sixty-four patients (7.3%) in the sotalol group died, compared with 52 (8.9%) in the placebo group. Although the mortality rate was 18% lower in the sotalol group, the difference was not statistically significant. There was a significant reduction in confirmed reinfarction, but not in all suspected reinfarctions. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_80480647</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80480647</sourcerecordid><originalsourceid>FETCH-LOGICAL-p206t-7520fb39b04aa09bb7d2f31eb3f9af157832d21f54144981dba86eca4806eec53</originalsourceid><addsrcrecordid>eNotzztrwzAUBWANLWma9icUNHUz6GVbHkP6CgS6tLO5kq7ARbZcSR7875vQTIcDHwfODdkyxrqqlULckfucf861kW29IZtGKqGV2JKXPbVxKimGgI6WNECg0dMcC4QYqI-JcroiJAq-YKLjGi0kd2HD5CHZMsTpgdx6CBkfr7kj32-vX4eP6vT5fjzsT9UsWFOqthbMG9kZpgBYZ0zrhJccjfQdeF63WgonuK8VV6rT3BnQDVpQmjWItpY78vy_O6f4u2Au_ThkiyHAhHHJvWYXqtozfLrCxYzo-jkNI6S1v96Wfz43UmY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80480647</pqid></control><display><type>article</type><title>A controlled trial of sotalol for 1 year after myocardial infarction</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Journals@Ovid Complete</source><creator>Julian, D G ; Jackson, F S ; Szekely, P ; Prescott, R J</creator><creatorcontrib>Julian, D G ; Jackson, F S ; Szekely, P ; Prescott, R J</creatorcontrib><description>We carried out a double-blind, randomized study, based at The Academic Department of Cardiology in Newcastle upon Tyne, to compare the effect of sotalol 320 mg once daily with that of placebo in patients from 20 hospitals who survived an acute myocardial infarction. Treatment was started 5-14 days after infarction in 1456 patients; 60% were randomized to sotalol and 40% to placebo. This represented 45% of those evaluated for entry. All patients were followed for 12 months and the analysis was done on an "intention-to-treat" principle. Sixty-four patients (7.3%) in the sotalol group died, compared with 52 (8.9%) in the placebo group. Although the mortality rate was 18% lower in the sotalol group, the difference was not statistically significant. There was a significant reduction in confirmed reinfarction, but not in all suspected reinfarctions.</description><identifier>ISSN: 0009-7322</identifier><identifier>PMID: 6342842</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Clinical Trials as Topic ; Double-Blind Method ; Humans ; Middle Aged ; Myocardial Infarction - drug therapy ; Myocardial Infarction - mortality ; Random Allocation ; Recurrence ; Scotland ; Sotalol - therapeutic use</subject><ispartof>Circulation (New York, N.Y.), 1983-06, Vol.67 (6 Pt 2), p.I61-I62</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6342842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Julian, D G</creatorcontrib><creatorcontrib>Jackson, F S</creatorcontrib><creatorcontrib>Szekely, P</creatorcontrib><creatorcontrib>Prescott, R J</creatorcontrib><title>A controlled trial of sotalol for 1 year after myocardial infarction</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>We carried out a double-blind, randomized study, based at The Academic Department of Cardiology in Newcastle upon Tyne, to compare the effect of sotalol 320 mg once daily with that of placebo in patients from 20 hospitals who survived an acute myocardial infarction. Treatment was started 5-14 days after infarction in 1456 patients; 60% were randomized to sotalol and 40% to placebo. This represented 45% of those evaluated for entry. All patients were followed for 12 months and the analysis was done on an "intention-to-treat" principle. Sixty-four patients (7.3%) in the sotalol group died, compared with 52 (8.9%) in the placebo group. Although the mortality rate was 18% lower in the sotalol group, the difference was not statistically significant. There was a significant reduction in confirmed reinfarction, but not in all suspected reinfarctions.</description><subject>Adult</subject><subject>Aged</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - mortality</subject><subject>Random Allocation</subject><subject>Recurrence</subject><subject>Scotland</subject><subject>Sotalol - therapeutic use</subject><issn>0009-7322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotzztrwzAUBWANLWma9icUNHUz6GVbHkP6CgS6tLO5kq7ARbZcSR7875vQTIcDHwfODdkyxrqqlULckfucf861kW29IZtGKqGV2JKXPbVxKimGgI6WNECg0dMcC4QYqI-JcroiJAq-YKLjGi0kd2HD5CHZMsTpgdx6CBkfr7kj32-vX4eP6vT5fjzsT9UsWFOqthbMG9kZpgBYZ0zrhJccjfQdeF63WgonuK8VV6rT3BnQDVpQmjWItpY78vy_O6f4u2Au_ThkiyHAhHHJvWYXqtozfLrCxYzo-jkNI6S1v96Wfz43UmY</recordid><startdate>198306</startdate><enddate>198306</enddate><creator>Julian, D G</creator><creator>Jackson, F S</creator><creator>Szekely, P</creator><creator>Prescott, R J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198306</creationdate><title>A controlled trial of sotalol for 1 year after myocardial infarction</title><author>Julian, D G ; Jackson, F S ; Szekely, P ; Prescott, R J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-7520fb39b04aa09bb7d2f31eb3f9af157832d21f54144981dba86eca4806eec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - mortality</topic><topic>Random Allocation</topic><topic>Recurrence</topic><topic>Scotland</topic><topic>Sotalol - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Julian, D G</creatorcontrib><creatorcontrib>Jackson, F S</creatorcontrib><creatorcontrib>Szekely, P</creatorcontrib><creatorcontrib>Prescott, R J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Julian, D G</au><au>Jackson, F S</au><au>Szekely, P</au><au>Prescott, R J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A controlled trial of sotalol for 1 year after myocardial infarction</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1983-06</date><risdate>1983</risdate><volume>67</volume><issue>6 Pt 2</issue><spage>I61</spage><epage>I62</epage><pages>I61-I62</pages><issn>0009-7322</issn><abstract>We carried out a double-blind, randomized study, based at The Academic Department of Cardiology in Newcastle upon Tyne, to compare the effect of sotalol 320 mg once daily with that of placebo in patients from 20 hospitals who survived an acute myocardial infarction. Treatment was started 5-14 days after infarction in 1456 patients; 60% were randomized to sotalol and 40% to placebo. This represented 45% of those evaluated for entry. All patients were followed for 12 months and the analysis was done on an "intention-to-treat" principle. Sixty-four patients (7.3%) in the sotalol group died, compared with 52 (8.9%) in the placebo group. Although the mortality rate was 18% lower in the sotalol group, the difference was not statistically significant. There was a significant reduction in confirmed reinfarction, but not in all suspected reinfarctions.</abstract><cop>United States</cop><pmid>6342842</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1983-06, Vol.67 (6 Pt 2), p.I61-I62 |
| issn | 0009-7322 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80480647 |
| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adult Aged Clinical Trials as Topic Double-Blind Method Humans Middle Aged Myocardial Infarction - drug therapy Myocardial Infarction - mortality Random Allocation Recurrence Scotland Sotalol - therapeutic use |
| title | A controlled trial of sotalol for 1 year after myocardial infarction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T18%3A35%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20controlled%20trial%20of%20sotalol%20for%201%20year%20after%20myocardial%20infarction&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=Julian,%20D%20G&rft.date=1983-06&rft.volume=67&rft.issue=6%20Pt%202&rft.spage=I61&rft.epage=I62&rft.pages=I61-I62&rft.issn=0009-7322&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E80480647%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80480647&rft_id=info:pmid/6342842&rfr_iscdi=true |