Cross-linking of CD23 antigen by its natural ligand (IgE) or by anti- CD23 antibody prevents B lymphocyte proliferation and differentiation

The possible role of CD23 in the activation of human B lymphocytes was systematically investigated by examining the effect of: 1) anti-CD23 mAb; 2) IgE or IgE-immune complexes and; 3) native or recombinant soluble CD23 of different m.w., on B cell proliferation. Intact anti-CD23 mAb or its F(ab'...

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