Restricted diversity of the variable region nucleotide sequences of the heavy and light chains of a human rheumatoid factor

The complete nucleotide sequences of the variable region genes of the heavy and light polypeptide chains of a human monoclonal rheumatoid factor (RF) produced from a human–mouse heterohybridoma were determined. The antibody, designated YES8c, contained V κIII, Jκ2, VH1, JH4, and a D gene segment of...

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Veröffentlicht in:	Arthritis and rheumatism 1991-03, Vol.34 (3), p.343-350
Hauptverfasser:	Ezaki, Ichiko, Shingu, Masao, Nobunaga, Masashi, Kanda, Hidetoshi, Watanabe, Takeshi, Sakai, Kouko, Fukui, Nobunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibody Diversity - genetics Base Sequence Genes, Immunoglobulin Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Light Chains - genetics Immunoglobulin Variable Region - genetics Molecular Sequence Data Rheumatoid Factor - genetics
Online-Zugang:	Volltext
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