Pharmacokinetics of pentamidine in Sprague-Dawley rats in late pregnancy

To our knowledge, placental transfer of pentamidine has not been previously studied in vivo. In the present study, the pharmacokinetics of pentamidine were analyzed in late gestation (18 days) among Sprague-Dawley rats. Pentamidine's kinetics were assessed in the following maternal compartments...

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Veröffentlicht in:	American journal of obstetrics and gynecology 1991-03, Vol.164 (3), p.927-930
Hauptverfasser:	Little, Bertis B., Harstad, Timothy H., Bawdon, Roger E., Sobhi, Sohrab, Roe, Daniel A., Knoll, Kraig A., Ghali, Fred E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Brain - metabolism Female Fetus - metabolism Maternal-Fetal Exchange Medical sciences Pentamidine Pentamidine - pharmacokinetics pharmacokinetics Pharmacology. Drug treatments Pregnancy Pregnancy, Animal - metabolism Rats Rats, Inbred Strains Species Specificity Sprague-Dawley rats Tissue Distribution
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