Tetrahydropyridyloxadiazoles : semirigid muscarinic ligands

Recent studies have described novel azabicycle-based muscarinic agonists which readily penetrate into the central nervous system and are capable of displaying high efficacy at cortical sites. The current paper describes the synthesis and biochemical assessment of semirigid muscarinic ligands which w...

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Veröffentlicht in:	Journal of medicinal chemistry 1991-03, Vol.34 (3), p.1086-1094
Hauptverfasser:	SHOWELL, G. A, GIBBONS, T. L, KNEEN, C. O, MACLEOD, A. M, MERCHANT, K, SAUNDERS, J, FREEDMAN, S. B, PATEL, S, BAKER, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Chemical Phenomena Chemistry Crystallization Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Hydrogen Bonding Male Molecular Conformation Molecular Structure Organic chemistry Oxadiazoles - chemical synthesis Oxadiazoles - chemistry Oxadiazoles - metabolism Parasympathomimetics - chemical synthesis Parasympathomimetics - chemistry Parasympathomimetics - metabolism Preparations and properties Pyridines - chemical synthesis Pyridines - chemistry Pyridines - metabolism Rats Rats, Inbred Strains Receptors, Muscarinic - metabolism Structure-Activity Relationship Thermodynamics X-Ray Diffraction
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