SYNTHESIS AND ACTIVITY OF BUTIROSIN DERIVATIVES WITH 5"-AMIDINO AND 5"-GUANIDINO SUBSTITUENTS

The preparation and antibacterial activity of the 5"-guanidino (6) and 5"-amidino (7) derivatives of 4'-deoxybutirosin A (1) as well as the 5"-guanidino derivative (8) of butirosin A are described. The key intermediates, tetra-N-benzyloxycarbonyl-5"-azido derivatives were se...

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Veröffentlicht in:	Journal of antibiotics 1991/01/25, Vol.44(1), pp.86-92
Hauptverfasser:	NARITA, YUKIO, MASUYOSHI, SHINJI, YAMASAKI, TETSURO, NAITO, TAKAYUKI, KAWAGUCHI, HIROSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Bacterial Infections - drug therapy Biological and medical sciences Butirosin Sulfate - chemical synthesis Butirosin Sulfate - chemistry Butirosin Sulfate - pharmacology Butirosin Sulfate - therapeutic use Escherichia coli - drug effects Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Methicillin Resistance Mice Molecular Structure Pharmacology. Drug treatments Staphylococcus aureus - drug effects
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