Evidence for the Location of the Receptor-Binding Site of Human Erythropoietin at the Carboxyl-Terminal Domain

Five different peptides (P1: 84-95; P2:152-166; P3: 52-63; P4: 7-23; P5: 110-123) homologous to relatively hydrophilic regions of human erythropoietin (huEpo) have been synthesized to identify biologically active domains of the hormone. All peptides were able to induce high titers of peptide-specifi...

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Veröffentlicht in:	Blood 1991-03, Vol.77 (6), p.1203-1210
Hauptverfasser:	Fibi, Mathias R., Stüber, Werner, Hintz-Obertreis, Petra, Lüben, Gerhard, Krumwieh, Dorothea, Siebold, Bernhard, Zettlmeiβl, Gerd, Küpper, Hans A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - analysis Biological and medical sciences Electronic Data Processing Electrophoresis - methods Epitopes - genetics Erythropoietin - metabolism Humans Immune Sera - immunology Immunoblotting Immunological methods for diagnosis and exploration Immunopathology Medical sciences Molecular Sequence Data Peptide Fragments - analysis Peptide Fragments - immunology Peptide Fragments - metabolism Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Receptors, Cell Surface - ultrastructure Receptors, Erythropoietin Recombinant Proteins - immunology Recombinant Proteins - metabolism Serological tests
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