Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex
Antidepressants and electroconvulsive shock therapy (ECS) have been reported to alter adenosine-sensitive adenylate cyclase responses in rat brain, suggesting an involvement of the purine in the mechanisms by which antidepressants and antidepressant therapy produce their clinical effects. Chronic (1...
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| Veröffentlicht in: | Neuroscience letters 1983-01, Vol.35 (1), p.47-51 |
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| container_title | Neuroscience letters |
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| creator | Williams, Michael Risley, Edwin A. Robinson, Janet L. |
| description | Antidepressants and electroconvulsive shock therapy (ECS) have been reported to alter adenosine-sensitive adenylate cyclase responses in rat brain, suggesting an involvement of the purine in the mechanisms by which antidepressants and antidepressant therapy produce their clinical effects. Chronic (14–21 days, 10 mg/kg/day by Alzet minipump) treatment with desmethylimipramine (DMI) and mianserin, while producing changes in β-adrenoceptor (DMI) and serotonin-2 (DMI and mianserin) radioligand binding similar to those reported in the literature, has no effect on adenosine A-1 radioligand binding. |
| doi_str_mv | 10.1016/0304-3940(83)90525-6 |
| format | Article |
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Chronic (14–21 days, 10 mg/kg/day by Alzet minipump) treatment with desmethylimipramine (DMI) and mianserin, while producing changes in β-adrenoceptor (DMI) and serotonin-2 (DMI and mianserin) radioligand binding similar to those reported in the literature, has no effect on adenosine A-1 radioligand binding.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(83)90525-6</identifier><identifier>PMID: 6302607</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>adenosine ; Adenosine - analogs & derivatives ; Adenosine - metabolism ; Animals ; antidepressants ; Cerebral Cortex - metabolism ; chronic treatment ; cortex ; Desipramine - pharmacology ; desmethylimipramine ; Dibenzazepines - pharmacology ; Male ; Membranes - metabolism ; mianserin ; Mianserin - pharmacology ; Radioligand Assay ; radioligand binding ; rats ; Rats - physiology ; Rats, Inbred Strains ; Receptors, Adrenergic, beta - metabolism ; Time Factors</subject><ispartof>Neuroscience letters, 1983-01, Vol.35 (1), p.47-51</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-5c49e12f57b46eac21a4ebde23d36471e850090bce1e060c5165c11caa61f6c23</citedby><cites>FETCH-LOGICAL-c303t-5c49e12f57b46eac21a4ebde23d36471e850090bce1e060c5165c11caa61f6c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304394083905256$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6302607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Michael</creatorcontrib><creatorcontrib>Risley, Edwin A.</creatorcontrib><creatorcontrib>Robinson, Janet L.</creatorcontrib><title>Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Antidepressants and electroconvulsive shock therapy (ECS) have been reported to alter adenosine-sensitive adenylate cyclase responses in rat brain, suggesting an involvement of the purine in the mechanisms by which antidepressants and antidepressant therapy produce their clinical effects. Chronic (14–21 days, 10 mg/kg/day by Alzet minipump) treatment with desmethylimipramine (DMI) and mianserin, while producing changes in β-adrenoceptor (DMI) and serotonin-2 (DMI and mianserin) radioligand binding similar to those reported in the literature, has no effect on adenosine A-1 radioligand binding.</description><subject>adenosine</subject><subject>Adenosine - analogs & derivatives</subject><subject>Adenosine - metabolism</subject><subject>Animals</subject><subject>antidepressants</subject><subject>Cerebral Cortex - metabolism</subject><subject>chronic treatment</subject><subject>cortex</subject><subject>Desipramine - pharmacology</subject><subject>desmethylimipramine</subject><subject>Dibenzazepines - pharmacology</subject><subject>Male</subject><subject>Membranes - metabolism</subject><subject>mianserin</subject><subject>Mianserin - pharmacology</subject><subject>Radioligand Assay</subject><subject>radioligand binding</subject><subject>rats</subject><subject>Rats - physiology</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Adrenergic, beta - metabolism</subject><subject>Time Factors</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OEzEQhC0EWrILbwCSTwgOA-3xz8xckFYRLEgrcYGz5bE7m0YzdrCdwJ54dTIk2iOc-lBfVUtVjL0Q8FaAMO9AgmrkoOB1L98MoFvdmEdsJfqubbqhax-z1QPylF2W8h0AtNDqgl0YCa2BbsV-r7c5RfKcIj_QIfGa0dUZY-U_qW55wDJj3d5PNNMuu5kichcDn8nFgvnoCgkLj6lyN1XM3AWMqSzYdSN4doHSRHeLZaQYKN4tn7Kr3Kdc8dcz9mTjpoLPz_eKffv44ev6U3P75ebz-vq28RJkbbRXA4p2o7tRGXS-FU7hGLCVQRrVCew1wACjR4FgwGthtBfCO2fExvhWXrFXp9xdTj_2WKqdqXicJhcx7YvtQRmp--6_oNDaSCmWRHUCfU6lZNzYXabZ5XsrwC4D2aV9u7Rve2n_DmTN0fbynL8fZwwPpvMiR_39ScdjGwfCbIsnjB4DZfTVhkT_fvAH6pag-w</recordid><startdate>19830131</startdate><enddate>19830131</enddate><creator>Williams, Michael</creator><creator>Risley, Edwin A.</creator><creator>Robinson, Janet L.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19830131</creationdate><title>Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex</title><author>Williams, Michael ; Risley, Edwin A. ; Robinson, Janet L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-5c49e12f57b46eac21a4ebde23d36471e850090bce1e060c5165c11caa61f6c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>adenosine</topic><topic>Adenosine - analogs & derivatives</topic><topic>Adenosine - metabolism</topic><topic>Animals</topic><topic>antidepressants</topic><topic>Cerebral Cortex - metabolism</topic><topic>chronic treatment</topic><topic>cortex</topic><topic>Desipramine - pharmacology</topic><topic>desmethylimipramine</topic><topic>Dibenzazepines - pharmacology</topic><topic>Male</topic><topic>Membranes - metabolism</topic><topic>mianserin</topic><topic>Mianserin - pharmacology</topic><topic>Radioligand Assay</topic><topic>radioligand binding</topic><topic>rats</topic><topic>Rats - physiology</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Adrenergic, beta - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Michael</creatorcontrib><creatorcontrib>Risley, Edwin A.</creatorcontrib><creatorcontrib>Robinson, Janet L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Michael</au><au>Risley, Edwin A.</au><au>Robinson, Janet L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1983-01-31</date><risdate>1983</risdate><volume>35</volume><issue>1</issue><spage>47</spage><epage>51</epage><pages>47-51</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>Antidepressants and electroconvulsive shock therapy (ECS) have been reported to alter adenosine-sensitive adenylate cyclase responses in rat brain, suggesting an involvement of the purine in the mechanisms by which antidepressants and antidepressant therapy produce their clinical effects. Chronic (14–21 days, 10 mg/kg/day by Alzet minipump) treatment with desmethylimipramine (DMI) and mianserin, while producing changes in β-adrenoceptor (DMI) and serotonin-2 (DMI and mianserin) radioligand binding similar to those reported in the literature, has no effect on adenosine A-1 radioligand binding.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>6302607</pmid><doi>10.1016/0304-3940(83)90525-6</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1983-01, Vol.35 (1), p.47-51 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | adenosine Adenosine - analogs & derivatives Adenosine - metabolism Animals antidepressants Cerebral Cortex - metabolism chronic treatment cortex Desipramine - pharmacology desmethylimipramine Dibenzazepines - pharmacology Male Membranes - metabolism mianserin Mianserin - pharmacology Radioligand Assay radioligand binding rats Rats - physiology Rats, Inbred Strains Receptors, Adrenergic, beta - metabolism Time Factors |
| title | Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex |
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