Linkage analysis in X-linked adrenoleukodystrophy and application in post- and prenatal diagnosis

We have performed linkage analysis with the DNA markers DXS52 and the clotting factor VIII gene (F8C), in several large families with X-linked adrenoleukodystrophy (ALD). The tight linkage to DXS52 could be extended giving a maximal LOD score of 22.5 at 1 cM. F8C was also tightly linked to ALD with...

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Veröffentlicht in:	Human genetics 1991-02, Vol.86 (4), p.404-407
Hauptverfasser:	VAN OOST, B. A, VAN ZANDVOORT, P. M, TÜNTE, W, BRUNNER, H. G, HOOGEBOOM, A. J. M, MAASWINKEL-MOOY, P. D, BAKKEREN, J, HAMEL, B, ROPERS, H. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenoleukodystrophy - diagnosis Adrenoleukodystrophy - genetics Biological and medical sciences coagulation factor VIII DNA Female genes Genetic Carrier Screening Genetic Linkage Humans Lod Score Male Medical sciences Neurology Polymorphism, Restriction Fragment Length Pregnancy Prenatal Diagnosis Recombination, Genetic X Chromosome
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