Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor

When post-nuclear homogenates from HL-60 granulocytes are incubated in the presence of CaCl 2, GTP γS and ethanol, phospholipase D (PLD) metabolizes both exogenous 2-[ 14C]arachidornyl-phosphatidylcholine and endogenous phosphatidyl[ 3H]choline to produce 2-[ 14C]arachidonyl-phosphatidic acid, 2-[ 1...

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Veröffentlicht in:	Biochemical and biophysical research communications 1991-02, Vol.175 (1), p.236-243
Hauptverfasser:	Anthes, John C., Wang, Peng, Siegel, Marvin I., Egan, Robert W., Motasim Billah, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Calcium - pharmacology Cell Line Cell Membrane - enzymology Choline - metabolism Cytosol - enzymology Enzyme Activation Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Granulocytes - enzymology guanine nucleotides Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Humans Hydrolases Leukemia, Promyelocytic, Acute leukocytes (granulocytic) Neoplasm Proteins - isolation & purification Neoplasm Proteins - metabolism Phospholipase D - metabolism Substrate Specificity
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