EFFECT OF I.V. ANAESTHESIA WITH PROPOFOL ON DRUG DISTRIBUTION AND METABOLISM IN THE DOG

We have studied the effect of i.v. anaesthesia with propofol in the emulsion (Intralipid) formulation on drug distribution and metabolism in six dogs using dual-route administration of propranolol as a model compound. Each dog was studied on two consecutive days: day 1 awake and day 2 during propofo...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1991-01, Vol.66 (1), p.66-72
Hauptverfasser:	PERRY, S. MOUTON, WHELAN, E., SHAY, S., WOOD, A.J.J., WOOD, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaesthetics Anesthesia, Intravenous Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Biotransformation - drug effects Biotransformation: propranolol Depression, Chemical Dogs Fat Emulsions, Intravenous - pharmacology intravenous: propofol Liver - blood supply Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Pharmacology: drug interaction propofol Propofol - pharmacology propranolol Propranolol - blood Propranolol - pharmacokinetics Protein Binding - drug effects Regional Blood Flow - drug effects
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