Utilization of Intravenously Administered β-Cellobiose and Maltose by Young Pigs
Intravenous solutions of glucose oligosaccharides are potential sources of carbohydrate-derived energy for patients requiring intravenous feeding. Relatively little is known about utilization of glucose oligosaccharides linked by β-glucosidic bonds. We compared the utilization of maltose (α-D-glucos...
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| Veröffentlicht in: | The Journal of nutrition 1983-05, Vol.113 (5), p.1039-1045 |
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| container_title | The Journal of nutrition |
| container_volume | 113 |
| creator | Andersen, Dean W. Daabees, Tahia T. Applebaum, A.E. Filer, L.J. Stegink, Lewis D. |
| description | Intravenous solutions of glucose oligosaccharides are potential sources of carbohydrate-derived energy for patients requiring intravenous feeding. Relatively little is known about utilization of glucose oligosaccharides linked by β-glucosidic bonds. We compared the utilization of maltose (α-D-glucosyl-1,4-D-glucose) and β-cellobiose (β-D-glucosyl-1,4-D-glucose) when administered intravenously (19 g per day) to young pigs for a 5-day period. Animals infused with maltose excreted 15% of the infused disaccharide over the 5-day infusion period. No evidence of maltose accumulation was noted in plasma, and kidney morphology was normal. Animals infused with β-cellobiose excreted 95% of the infused disaccharide in the urine. The mean (±SD) plasma total glucose concentration increased significantly over base-line values of 114 ± 39 mg/dl to a value of 180 ± 28 mg/dl during cellobiose infusion, indicating accumulation of cellobiose in body water. Kidney morphology in cellobiose-infused animals was normal. Intravenously infused β-cellobiose is poorly utilized by the pig when compared with the utilization of its α-1,4 linked isomer, maltose. |
| doi_str_mv | 10.1093/jn/113.5.1039 |
| format | Article |
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Relatively little is known about utilization of glucose oligosaccharides linked by β-glucosidic bonds. We compared the utilization of maltose (α-D-glucosyl-1,4-D-glucose) and β-cellobiose (β-D-glucosyl-1,4-D-glucose) when administered intravenously (19 g per day) to young pigs for a 5-day period. Animals infused with maltose excreted 15% of the infused disaccharide over the 5-day infusion period. No evidence of maltose accumulation was noted in plasma, and kidney morphology was normal. Animals infused with β-cellobiose excreted 95% of the infused disaccharide in the urine. The mean (±SD) plasma total glucose concentration increased significantly over base-line values of 114 ± 39 mg/dl to a value of 180 ± 28 mg/dl during cellobiose infusion, indicating accumulation of cellobiose in body water. Kidney morphology in cellobiose-infused animals was normal. Intravenously infused β-cellobiose is poorly utilized by the pig when compared with the utilization of its α-1,4 linked isomer, maltose.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/113.5.1039</identifier><identifier>PMID: 6842298</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Carbohydrates ; Carbohydrates - urine ; cellobiose ; Cellobiose - administration & dosage ; Cellobiose - metabolism ; Disaccharides - metabolism ; Fundamental and applied biological sciences. Psychology ; Infusions, Parenteral ; intravenous feeding ; Kidney - anatomy & histology ; maltose ; Maltose - administration & dosage ; Maltose - metabolism ; Metabolisms and neurohumoral controls ; pig ; Swine ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 1983-05, Vol.113 (5), p.1039-1045</ispartof><rights>1983 American Society for Nutrition.</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-5a4758a759af70fb1833dc6fc71964482cc3731e948743cafc213b7ad26961a43</citedby><cites>FETCH-LOGICAL-c404t-5a4758a759af70fb1833dc6fc71964482cc3731e948743cafc213b7ad26961a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9492582$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6842298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersen, Dean W.</creatorcontrib><creatorcontrib>Daabees, Tahia T.</creatorcontrib><creatorcontrib>Applebaum, A.E.</creatorcontrib><creatorcontrib>Filer, L.J.</creatorcontrib><creatorcontrib>Stegink, Lewis D.</creatorcontrib><title>Utilization of Intravenously Administered β-Cellobiose and Maltose by Young Pigs</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Intravenous solutions of glucose oligosaccharides are potential sources of carbohydrate-derived energy for patients requiring intravenous feeding. Relatively little is known about utilization of glucose oligosaccharides linked by β-glucosidic bonds. We compared the utilization of maltose (α-D-glucosyl-1,4-D-glucose) and β-cellobiose (β-D-glucosyl-1,4-D-glucose) when administered intravenously (19 g per day) to young pigs for a 5-day period. Animals infused with maltose excreted 15% of the infused disaccharide over the 5-day infusion period. No evidence of maltose accumulation was noted in plasma, and kidney morphology was normal. Animals infused with β-cellobiose excreted 95% of the infused disaccharide in the urine. The mean (±SD) plasma total glucose concentration increased significantly over base-line values of 114 ± 39 mg/dl to a value of 180 ± 28 mg/dl during cellobiose infusion, indicating accumulation of cellobiose in body water. Kidney morphology in cellobiose-infused animals was normal. Intravenously infused β-cellobiose is poorly utilized by the pig when compared with the utilization of its α-1,4 linked isomer, maltose.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates</subject><subject>Carbohydrates - urine</subject><subject>cellobiose</subject><subject>Cellobiose - administration & dosage</subject><subject>Cellobiose - metabolism</subject><subject>Disaccharides - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Infusions, Parenteral</subject><subject>intravenous feeding</subject><subject>Kidney - anatomy & histology</subject><subject>maltose</subject><subject>Maltose - administration & dosage</subject><subject>Maltose - metabolism</subject><subject>Metabolisms and neurohumoral controls</subject><subject>pig</subject><subject>Swine</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMoWi9Ll8IsxN20uU-yLMUbKCrowlXIZDIlZZrUZFqoj-WD-EymtHTn6pzD_3H4-QC4RHCIoCSjmR8hRIYsX0QegAFiFJUcQXgIBhBiXBLE-Qk4TWkGIURUimNwzAXFWIoBePvoXee-de-CL0JbPPo-6pX1YZm6dTFu5s671Ntom-L3p5zYrgu1C8kW2jfFs-76zV6vi8-w9NPi1U3TOThqdZfsxW6egY-72_fJQ_n0cv84GT-VhkLal0zTigldManbCrY1EoQ0hremQpJTKrAxpCLISioqSoxuDUakrnSDueRIU3IGbrZ_FzF8LW3q1dwlkwtqb3N7JSBlnEmSwXILmhhSirZVi-jmOq4VgmqjUM28ygoVUxuFmb_aPV7Wc9vs6Z2znF_vcp2M7tqovXFpj0kqMRM4Y9UWs1nCytmoknHWG9u4aE2vmuD-KfAHZjuL5g</recordid><startdate>198305</startdate><enddate>198305</enddate><creator>Andersen, Dean W.</creator><creator>Daabees, Tahia T.</creator><creator>Applebaum, A.E.</creator><creator>Filer, L.J.</creator><creator>Stegink, Lewis D.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198305</creationdate><title>Utilization of Intravenously Administered β-Cellobiose and Maltose by Young Pigs</title><author>Andersen, Dean W. ; Daabees, Tahia T. ; Applebaum, A.E. ; Filer, L.J. ; Stegink, Lewis D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-5a4758a759af70fb1833dc6fc71964482cc3731e948743cafc213b7ad26961a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates</topic><topic>Carbohydrates - urine</topic><topic>cellobiose</topic><topic>Cellobiose - administration & dosage</topic><topic>Cellobiose - metabolism</topic><topic>Disaccharides - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Infusions, Parenteral</topic><topic>intravenous feeding</topic><topic>Kidney - anatomy & histology</topic><topic>maltose</topic><topic>Maltose - administration & dosage</topic><topic>Maltose - metabolism</topic><topic>Metabolisms and neurohumoral controls</topic><topic>pig</topic><topic>Swine</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andersen, Dean W.</creatorcontrib><creatorcontrib>Daabees, Tahia T.</creatorcontrib><creatorcontrib>Applebaum, A.E.</creatorcontrib><creatorcontrib>Filer, L.J.</creatorcontrib><creatorcontrib>Stegink, Lewis D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersen, Dean W.</au><au>Daabees, Tahia T.</au><au>Applebaum, A.E.</au><au>Filer, L.J.</au><au>Stegink, Lewis D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utilization of Intravenously Administered β-Cellobiose and Maltose by Young Pigs</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1983-05</date><risdate>1983</risdate><volume>113</volume><issue>5</issue><spage>1039</spage><epage>1045</epage><pages>1039-1045</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Intravenous solutions of glucose oligosaccharides are potential sources of carbohydrate-derived energy for patients requiring intravenous feeding. Relatively little is known about utilization of glucose oligosaccharides linked by β-glucosidic bonds. We compared the utilization of maltose (α-D-glucosyl-1,4-D-glucose) and β-cellobiose (β-D-glucosyl-1,4-D-glucose) when administered intravenously (19 g per day) to young pigs for a 5-day period. Animals infused with maltose excreted 15% of the infused disaccharide over the 5-day infusion period. No evidence of maltose accumulation was noted in plasma, and kidney morphology was normal. Animals infused with β-cellobiose excreted 95% of the infused disaccharide in the urine. The mean (±SD) plasma total glucose concentration increased significantly over base-line values of 114 ± 39 mg/dl to a value of 180 ± 28 mg/dl during cellobiose infusion, indicating accumulation of cellobiose in body water. Kidney morphology in cellobiose-infused animals was normal. Intravenously infused β-cellobiose is poorly utilized by the pig when compared with the utilization of its α-1,4 linked isomer, maltose.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>6842298</pmid><doi>10.1093/jn/113.5.1039</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Carbohydrates Carbohydrates - urine cellobiose Cellobiose - administration & dosage Cellobiose - metabolism Disaccharides - metabolism Fundamental and applied biological sciences. Psychology Infusions, Parenteral intravenous feeding Kidney - anatomy & histology maltose Maltose - administration & dosage Maltose - metabolism Metabolisms and neurohumoral controls pig Swine Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Utilization of Intravenously Administered β-Cellobiose and Maltose by Young Pigs |
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