Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones

A series of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones was prepared and evaluated for antihypertensive activity in the spontaneously hypertensive rat (SHR). The basic ring system was prepared in one step by condensation of dilithiated (tert-butoxycarbonyl)aniline (3...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 1983-05, Vol.26 (5), p.657-661
Hauptverfasser:	Clark, Robin D, Caroon, Joan M, Kluge, Arthur F, Repke, David B, Roszkowski, Adolph P, Strosberg, Arthur M, Baker, Stephen, Bitter, Susan M, Okada, Marlys D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hypertension - drug therapy Male Oxazines - therapeutic use Piperidines - therapeutic use Piperidones - therapeutic use Rats Spiro Compounds - therapeutic use Structure-Activity Relationship Systole - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!