Pharmacokinetics and pharmacodynamics of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione in patients with postmenopausal breast cancer

The pyridylglutarimide 3-ethyl-3-(4-pyridyl)-piperidine-2,6-dione (PyG) is a novel inhibitor of aromatase that was shown to cause effective suppression of plasma oestradiol levels in postmenopausal patients. In four patients receiving oral doses of PyG (500 mg) twice daily for 3-4 days, oestradiol l...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1991-01, Vol.27 (5), p.367-372
Hauptverfasser:	HAYNES, B. P, JARMAN, M, DOWSETT, M, MEHTA, A, LOÊNNING, P. E, GRIGGS, L. J, JONES, A, POWLES, T, STEIN, R, COOMBES, R. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglutethimide - analogs & derivatives Aminoglutethimide - pharmacokinetics Aminoglutethimide - therapeutic use Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - drug therapy Chemotherapy Estradiol - blood Estrogens, Conjugated (USP) - blood Estrone - analogs & derivatives Estrone - blood Female Humans Medical sciences Middle Aged Pharmacology. Drug treatments Time Factors
Online-Zugang:	Volltext
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