The effect of short-term dietary supplementation with glucose on gastric emptying in humans
In order to test whether gastric motility can adapt to changes in nutrient load, gastric emptying of hyperosmotic glucose and protein drinks was measured by applied potential tomography in two groups of ten volunteers following dietary supplementation with 400 g glucose/d for 3 d. The half emptying...
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| Veröffentlicht in: | British journal of nutrition 1991-01, Vol.65 (1), p.15-19 |
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| creator | Cunningham, Karen M. Horowitz, Michael Read, Nicholas W. |
| description | In order to test whether gastric motility can adapt to changes in nutrient load, gastric emptying of hyperosmotic glucose and protein drinks was measured by applied potential tomography in two groups of ten volunteers following dietary supplementation with 400 g glucose/d for 3 d. The half emptying time for the glucose test meal was significantly faster after the standard diet had been supplemented with glucose compared with the standard diet alone (median and range, 20.7 (4.6–36.8) ν. 29.1 (19.8–38.4) min; P < 0.05), while the emptying of the protein drink (Oxo; Brooke Bond Ltd) was unchanged (median and range, 18.0 (12.5–23.6) ν. 16.1 (9.6–22.7) min). These results suggest that rapid and specific adaptation of the small intestinal regulatory mechanisms for gastric emptying of nutrient solutions can occur in response to increases in dietary load. This adaptation may be explained by desensitization of nutrient receptors or by a reduction in the area of receptor field exposed to nutrients caused by increased absorption of glucose in the upper small intestine |
| doi_str_mv | 10.1079/BJN19910061 |
| format | Article |
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The half emptying time for the glucose test meal was significantly faster after the standard diet had been supplemented with glucose compared with the standard diet alone (median and range, 20.7 (4.6–36.8) ν. 29.1 (19.8–38.4) min; P < 0.05), while the emptying of the protein drink (Oxo; Brooke Bond Ltd) was unchanged (median and range, 18.0 (12.5–23.6) ν. 16.1 (9.6–22.7) min). These results suggest that rapid and specific adaptation of the small intestinal regulatory mechanisms for gastric emptying of nutrient solutions can occur in response to increases in dietary load. 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The half emptying time for the glucose test meal was significantly faster after the standard diet had been supplemented with glucose compared with the standard diet alone (median and range, 20.7 (4.6–36.8) ν. 29.1 (19.8–38.4) min; P < 0.05), while the emptying of the protein drink (Oxo; Brooke Bond Ltd) was unchanged (median and range, 18.0 (12.5–23.6) ν. 16.1 (9.6–22.7) min). These results suggest that rapid and specific adaptation of the small intestinal regulatory mechanisms for gastric emptying of nutrient solutions can occur in response to increases in dietary load. This adaptation may be explained by desensitization of nutrient receptors or by a reduction in the area of receptor field exposed to nutrients caused by increased absorption of glucose in the upper small intestine</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Diet and Gastrointestinal Function</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>Dietary Proteins - pharmacology</subject><subject>Electric Conductivity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric emptying</subject><subject>Gastric Emptying - drug effects</subject><subject>Glucoreceptors</subject><subject>Glucose Solution, Hypertonic - pharmacology</subject><subject>Humans</subject><subject>Intestinal adaptation</subject><subject>Male</subject><subject>Osmolar Concentration</subject><subject>Stimulation, Chemical</subject><subject>Stomach</subject><subject>Time Factors</subject><subject>Vertebrates: digestive system</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1P3DAQxS1UBFvgxBnJl_ZShY43iZ0cCypbPlSEdrm0B8uxx7um-cJ2BPz3zWpXwIHT6On95mnmEXLM4JSBKL-fXf1mZckAONshE5aJPJlyPv1EJgAgEsayfJ98DuFhlAWDco_sjbxg02JC_i5WSNFa1JF2loZV52MS0TfUOIzKv9Aw9H2NDbZRRde19MnFFV3Wg-4C0lEvVYjeaYpNH19cu6SupauhUW04JLtW1QGPtvOA3F_8XJz_Sm5uZ5fnP24SnU1FTIw2BZZKQwmmECznmmtjjDIAVcqZLW1VCSOs5QpVnjNgVkClc5HmvAKu0wPydZPb--5xwBBl44LGulYtdkOQBWTrNTGC3zag9l0IHq3svWvGJyUDua5SvqtypE-2sUPVoHljN92N_petr4JWtfWq1S68w7JUCLbOSTacCxGfX33l_0kuUpFLPruT2ez6z3x-MZNnb7xWTeWdWaJ86AbfjhV-eOd_UhOaTw</recordid><startdate>199101</startdate><enddate>199101</enddate><creator>Cunningham, Karen M.</creator><creator>Horowitz, Michael</creator><creator>Read, Nicholas W.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199101</creationdate><title>The effect of short-term dietary supplementation with glucose on gastric emptying in humans</title><author>Cunningham, Karen M. ; Horowitz, Michael ; Read, Nicholas W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-dcd8e9ac090d87156c6cdddad00b361f9fbb7d7ff6aea55101f70bc57356b06c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Diet and Gastrointestinal Function</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>Dietary Proteins - pharmacology</topic><topic>Electric Conductivity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric emptying</topic><topic>Gastric Emptying - drug effects</topic><topic>Glucoreceptors</topic><topic>Glucose Solution, Hypertonic - pharmacology</topic><topic>Humans</topic><topic>Intestinal adaptation</topic><topic>Male</topic><topic>Osmolar Concentration</topic><topic>Stimulation, Chemical</topic><topic>Stomach</topic><topic>Time Factors</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cunningham, Karen M.</creatorcontrib><creatorcontrib>Horowitz, Michael</creatorcontrib><creatorcontrib>Read, Nicholas W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cunningham, Karen M.</au><au>Horowitz, Michael</au><au>Read, Nicholas W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of short-term dietary supplementation with glucose on gastric emptying in humans</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1991-01</date><risdate>1991</risdate><volume>65</volume><issue>1</issue><spage>15</spage><epage>19</epage><pages>15-19</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>In order to test whether gastric motility can adapt to changes in nutrient load, gastric emptying of hyperosmotic glucose and protein drinks was measured by applied potential tomography in two groups of ten volunteers following dietary supplementation with 400 g glucose/d for 3 d. The half emptying time for the glucose test meal was significantly faster after the standard diet had been supplemented with glucose compared with the standard diet alone (median and range, 20.7 (4.6–36.8) ν. 29.1 (19.8–38.4) min; P < 0.05), while the emptying of the protein drink (Oxo; Brooke Bond Ltd) was unchanged (median and range, 18.0 (12.5–23.6) ν. 16.1 (9.6–22.7) min). These results suggest that rapid and specific adaptation of the small intestinal regulatory mechanisms for gastric emptying of nutrient solutions can occur in response to increases in dietary load. This adaptation may be explained by desensitization of nutrient receptors or by a reduction in the area of receptor field exposed to nutrients caused by increased absorption of glucose in the upper small intestine</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>1997128</pmid><doi>10.1079/BJN19910061</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 1991-01, Vol.65 (1), p.15-19 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Adult Biological and medical sciences Diet and Gastrointestinal Function Dietary Carbohydrates - pharmacology Dietary Proteins - pharmacology Electric Conductivity Fundamental and applied biological sciences. Psychology Gastric emptying Gastric Emptying - drug effects Glucoreceptors Glucose Solution, Hypertonic - pharmacology Humans Intestinal adaptation Male Osmolar Concentration Stimulation, Chemical Stomach Time Factors Vertebrates: digestive system |
| title | The effect of short-term dietary supplementation with glucose on gastric emptying in humans |
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