Possible involvement of NADPH-cytochrome P450 reductase and cytochrome b5 on β-ketostearoyl-CoA reduction in microsomal fatty acid chain elongation supported by NADPH

The chain elongation products from [2- 14C]malonyl-CoA and palmitoyl-CoA by rat liver microsomes initiated by NADPH were found mainly to be 18:1 and 18:0. When anti-NADPH-cytochrome P450 reductase or anti-cytochrome b 5 immunoglobulin G were included in this system, not only was the overall chain el...

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Veröffentlicht in:	FEBS letters 1983-05, Vol.155 (1), p.11-14
Hauptverfasser:	Nagao, Masaki, Ishibashi, Teruo, Okayasu, Takako, Imai, Yoh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - metabolism Animals Chain elongation Chromatography, Gas Cytochrome b Group - metabolism Cytochrome b5 Cytochromes b5 F pT Fatty acid Fatty Acids - metabolism Immunochemical evidence Microsome Microsomes, Liver - metabolism NADP - metabolism NADPH-Ferrihemoprotein Reductase - metabolism Rabbits Rats
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