Association between histocompatability antigens (HLA) and nasal carriage of Staphylococcus aureus
Department of Bacteriology, Institute of Dermatology, Homerton Grove, London E9 * Department of Medicine, Regional Hospital, Galway, Ireland Received March 5, 1982 Accepted September 19, 1982 We investigated the association between phenotypes of histocompatability antigen (HLA) and nasal carriage of...
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| Veröffentlicht in: | Journal of medical microbiology 1983-05, Vol.16 (2), p.215-220 |
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| container_title | Journal of medical microbiology |
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| creator | KINSMAN, OONAGH S MCKENNA, RACHEL NOBLE, W. C |
| description | Department of Bacteriology, Institute of Dermatology, Homerton Grove, London E9
* Department of Medicine, Regional Hospital, Galway, Ireland
Received March 5, 1982
Accepted September 19, 1982
We investigated the association between phenotypes of histocompatability antigen (HLA) and nasal carriage of Staphylococcus aureus in two populations—healthy laboratory workers and patients attending an outpatients' clinic. When data from the two sources were pooled, it was evident that the presence of HLA-DR3 was associated with carriage, and the presence of HLA-DR2, HLA-DR1 and HLA-Bw35 with lack of carriage. However, since each person may have two antigenic specificities encoded at the HLA-A, the HLA-B, and the HLA-DR loci, the carriage of the organism was analysed for paired combinations of the more frequent phenotypes. For example, the lack of carriage evident with HLA-DR1 was more marked with the DR1-A11 and DR1-B7 combinations while the predisposition towards carriage shown with HLA-DR3 was more marked with the DR3-DR5 combination. The importance of the analysis of antigen combinations is discussed in relation to association of single antigens with carriage of S. aureus . |
| doi_str_mv | 10.1099/00222615-16-2-215 |
| format | Article |
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* Department of Medicine, Regional Hospital, Galway, Ireland
Received March 5, 1982
Accepted September 19, 1982
We investigated the association between phenotypes of histocompatability antigen (HLA) and nasal carriage of Staphylococcus aureus in two populations—healthy laboratory workers and patients attending an outpatients' clinic. When data from the two sources were pooled, it was evident that the presence of HLA-DR3 was associated with carriage, and the presence of HLA-DR2, HLA-DR1 and HLA-Bw35 with lack of carriage. However, since each person may have two antigenic specificities encoded at the HLA-A, the HLA-B, and the HLA-DR loci, the carriage of the organism was analysed for paired combinations of the more frequent phenotypes. For example, the lack of carriage evident with HLA-DR1 was more marked with the DR1-A11 and DR1-B7 combinations while the predisposition towards carriage shown with HLA-DR3 was more marked with the DR3-DR5 combination. The importance of the analysis of antigen combinations is discussed in relation to association of single antigens with carriage of S. aureus .</description><identifier>ISSN: 0022-2615</identifier><identifier>EISSN: 1473-5644</identifier><identifier>DOI: 10.1099/00222615-16-2-215</identifier><identifier>PMID: 6573514</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Adult ; Carrier State ; Histocompatibility Antigens Class II ; HLA Antigens ; HLA-A Antigens ; HLA-B Antigens ; HLA-DR Antigens ; Humans ; Nasal Mucosa - microbiology ; Staphylococcal Infections - genetics ; Staphylococcal Infections - immunology ; Staphylococcus aureus - growth & development</subject><ispartof>Journal of medical microbiology, 1983-05, Vol.16 (2), p.215-220</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-d364b07b950eecda29220a883c54d820f830307ae9be8867b9597c3b3fec41b03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3746,3747,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6573514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KINSMAN, OONAGH S</creatorcontrib><creatorcontrib>MCKENNA, RACHEL</creatorcontrib><creatorcontrib>NOBLE, W. C</creatorcontrib><title>Association between histocompatability antigens (HLA) and nasal carriage of Staphylococcus aureus</title><title>Journal of medical microbiology</title><addtitle>J Med Microbiol</addtitle><description>Department of Bacteriology, Institute of Dermatology, Homerton Grove, London E9
* Department of Medicine, Regional Hospital, Galway, Ireland
Received March 5, 1982
Accepted September 19, 1982
We investigated the association between phenotypes of histocompatability antigen (HLA) and nasal carriage of Staphylococcus aureus in two populations—healthy laboratory workers and patients attending an outpatients' clinic. When data from the two sources were pooled, it was evident that the presence of HLA-DR3 was associated with carriage, and the presence of HLA-DR2, HLA-DR1 and HLA-Bw35 with lack of carriage. However, since each person may have two antigenic specificities encoded at the HLA-A, the HLA-B, and the HLA-DR loci, the carriage of the organism was analysed for paired combinations of the more frequent phenotypes. For example, the lack of carriage evident with HLA-DR1 was more marked with the DR1-A11 and DR1-B7 combinations while the predisposition towards carriage shown with HLA-DR3 was more marked with the DR3-DR5 combination. The importance of the analysis of antigen combinations is discussed in relation to association of single antigens with carriage of S. aureus .</description><subject>Adult</subject><subject>Carrier State</subject><subject>Histocompatibility Antigens Class II</subject><subject>HLA Antigens</subject><subject>HLA-A Antigens</subject><subject>HLA-B Antigens</subject><subject>HLA-DR Antigens</subject><subject>Humans</subject><subject>Nasal Mucosa - microbiology</subject><subject>Staphylococcal Infections - genetics</subject><subject>Staphylococcal Infections - immunology</subject><subject>Staphylococcus aureus - growth & development</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLKzEYhoMc0Xr5AS6ErM7RxWhuc1sW8QYFF-o6fMl800ZmJjXJUPrvz5RWV-Hjfd438BByxdkdZ3V9z5gQouB5xotMZILnR2TGVSmzvFDqD5nt8mwHnJKzGL8Y46WU9Qk5KfJS5lzNCMxj9NZBcn6gBtMGcaArF5O3vl9DAuM6l7YUhuSWOER687KY305nQweI0FELIThYIvUtfU-wXm27qWrtGCmMAcd4QY5b6CJeHt5z8vn0-PHwki3enl8f5ovMypKnrJGFMqw0dc4QbQOiFoJBVUmbq6YSrK0kk6wErA1WVbED69JKI1u0ihsmz8nf_e46-O8RY9K9ixa7Dgb0Y9QVU7lSqphAvgdt8DEGbPU6uB7CVnOmd1r1j1bNCy30pHXqXB_GR9Nj89s4eJzyf_t85ZarjQuoJ1m9m34wzuuvvv9d-g8z-YEP</recordid><startdate>198305</startdate><enddate>198305</enddate><creator>KINSMAN, OONAGH S</creator><creator>MCKENNA, RACHEL</creator><creator>NOBLE, W. C</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198305</creationdate><title>Association between histocompatability antigens (HLA) and nasal carriage of Staphylococcus aureus</title><author>KINSMAN, OONAGH S ; MCKENNA, RACHEL ; NOBLE, W. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-d364b07b950eecda29220a883c54d820f830307ae9be8867b9597c3b3fec41b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Carrier State</topic><topic>Histocompatibility Antigens Class II</topic><topic>HLA Antigens</topic><topic>HLA-A Antigens</topic><topic>HLA-B Antigens</topic><topic>HLA-DR Antigens</topic><topic>Humans</topic><topic>Nasal Mucosa - microbiology</topic><topic>Staphylococcal Infections - genetics</topic><topic>Staphylococcal Infections - immunology</topic><topic>Staphylococcus aureus - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KINSMAN, OONAGH S</creatorcontrib><creatorcontrib>MCKENNA, RACHEL</creatorcontrib><creatorcontrib>NOBLE, W. C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KINSMAN, OONAGH S</au><au>MCKENNA, RACHEL</au><au>NOBLE, W. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between histocompatability antigens (HLA) and nasal carriage of Staphylococcus aureus</atitle><jtitle>Journal of medical microbiology</jtitle><addtitle>J Med Microbiol</addtitle><date>1983-05</date><risdate>1983</risdate><volume>16</volume><issue>2</issue><spage>215</spage><epage>220</epage><pages>215-220</pages><issn>0022-2615</issn><eissn>1473-5644</eissn><abstract>Department of Bacteriology, Institute of Dermatology, Homerton Grove, London E9
* Department of Medicine, Regional Hospital, Galway, Ireland
Received March 5, 1982
Accepted September 19, 1982
We investigated the association between phenotypes of histocompatability antigen (HLA) and nasal carriage of Staphylococcus aureus in two populations—healthy laboratory workers and patients attending an outpatients' clinic. When data from the two sources were pooled, it was evident that the presence of HLA-DR3 was associated with carriage, and the presence of HLA-DR2, HLA-DR1 and HLA-Bw35 with lack of carriage. However, since each person may have two antigenic specificities encoded at the HLA-A, the HLA-B, and the HLA-DR loci, the carriage of the organism was analysed for paired combinations of the more frequent phenotypes. For example, the lack of carriage evident with HLA-DR1 was more marked with the DR1-A11 and DR1-B7 combinations while the predisposition towards carriage shown with HLA-DR3 was more marked with the DR3-DR5 combination. The importance of the analysis of antigen combinations is discussed in relation to association of single antigens with carriage of S. aureus .</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>6573514</pmid><doi>10.1099/00222615-16-2-215</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of medical microbiology, 1983-05, Vol.16 (2), p.215-220 |
| issn | 0022-2615 1473-5644 |
| language | eng |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; Microbiology Society; Alma/SFX Local Collection |
| subjects | Adult Carrier State Histocompatibility Antigens Class II HLA Antigens HLA-A Antigens HLA-B Antigens HLA-DR Antigens Humans Nasal Mucosa - microbiology Staphylococcal Infections - genetics Staphylococcal Infections - immunology Staphylococcus aureus - growth & development |
| title | Association between histocompatability antigens (HLA) and nasal carriage of Staphylococcus aureus |
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