Granulocyte Colony-Stimulating Factor Enhances the Phagocytic and Bactericidal Activity of Normal and Defective Human Neutrophils
Granulocyte colony-stimulating factor (G-CSF) stimulates proliferation of myeloid cells and maybe a valuable adjunct in prevention and treatment of neutropenia-associated infections. Neutrophil (PMNL)phagocytic and microbicidal functions against Staphylococcus aureus and Candida albicans blastoconid...
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| Veröffentlicht in: | The Journal of infectious diseases 1991-03, Vol.163 (3), p.579-583 |
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| creator | Roilides, Emmanuel Walsh, Thomas J. Pizzo, Philip A. Rubin, Marc |
| description | Granulocyte colony-stimulating factor (G-CSF) stimulates proliferation of myeloid cells and maybe a valuable adjunct in prevention and treatment of neutropenia-associated infections. Neutrophil (PMNL)phagocytic and microbicidal functions against Staphylococcus aureus and Candida albicans blastoconidia were therefore evaluated. Bacterial phagocytosis and bactericidal activity were significantly enhanced by ∼ 50%–70% after preincubation of normal PMNLw ith G-CSF in concentrations of 1000–4000 units/ml for 10 min at 37°C. G-CSF in similar concentrations enhanced the defective bactericidal activity of PMNL from HIV-1-infected patients by ∼70%–150% and reached the baseline control PMNL killing. However, G-CSF enhanced neither phagocytosis nor fungicidal activity of normal PMNL against C. albicans blastoconidia. These data demonstrate that G-CSF enhances the antibacterial but not the antifungal activities of human PMNL in vitro and also improves the defective PMNLbactericidal activity of HIV-1-infected patients. |
| doi_str_mv | 10.1093/infdis/163.3.579 |
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Neutrophil (PMNL)phagocytic and microbicidal functions against Staphylococcus aureus and Candida albicans blastoconidia were therefore evaluated. Bacterial phagocytosis and bactericidal activity were significantly enhanced by ∼ 50%–70% after preincubation of normal PMNLw ith G-CSF in concentrations of 1000–4000 units/ml for 10 min at 37°C. G-CSF in similar concentrations enhanced the defective bactericidal activity of PMNL from HIV-1-infected patients by ∼70%–150% and reached the baseline control PMNL killing. However, G-CSF enhanced neither phagocytosis nor fungicidal activity of normal PMNL against C. albicans blastoconidia. These data demonstrate that G-CSF enhances the antibacterial but not the antifungal activities of human PMNL in vitro and also improves the defective PMNLbactericidal activity of HIV-1-infected patients.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/163.3.579</identifier><identifier>PMID: 1704903</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University Chicago Press</publisher><subject>Acquired Immunodeficiency Syndrome - immunology ; Adult ; AIDS-Related Complex - immunology ; AIDS/HIV ; Analysis of the immune response. Humoral and cellular immunity ; Analysis of Variance ; Bacteria ; Biological and medical sciences ; Blood Bactericidal Activity - physiology ; Candida albicans ; Candida albicans - immunology ; Child ; Colony stimulating factors ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Fungi ; Granulocyte Colony-Stimulating Factor - physiology ; Granulocytes ; Humans ; Immunobiology ; In Vitro Techniques ; Infections ; Major Articles ; Miscellaneous ; Neutrophils ; Neutrophils - physiology ; Phagocytosis ; Phagocytosis - physiology ; Pretreatment ; Reference Values ; Regulatory factors and their cellular receptors ; Staphylococcus aureus ; Staphylococcus aureus - immunology ; Superoxides</subject><ispartof>The Journal of infectious diseases, 1991-03, Vol.163 (3), p.579-583</ispartof><rights>Copyright 1990 University of Chicago</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-75dd7223233712757b8051ae79cd23dc3974715a061fa1622c7552ebc733860f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30123168$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30123168$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4970681$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1704903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roilides, Emmanuel</creatorcontrib><creatorcontrib>Walsh, Thomas J.</creatorcontrib><creatorcontrib>Pizzo, Philip A.</creatorcontrib><creatorcontrib>Rubin, Marc</creatorcontrib><title>Granulocyte Colony-Stimulating Factor Enhances the Phagocytic and Bactericidal Activity of Normal and Defective Human Neutrophils</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Granulocyte colony-stimulating factor (G-CSF) stimulates proliferation of myeloid cells and maybe a valuable adjunct in prevention and treatment of neutropenia-associated infections. Neutrophil (PMNL)phagocytic and microbicidal functions against Staphylococcus aureus and Candida albicans blastoconidia were therefore evaluated. Bacterial phagocytosis and bactericidal activity were significantly enhanced by ∼ 50%–70% after preincubation of normal PMNLw ith G-CSF in concentrations of 1000–4000 units/ml for 10 min at 37°C. G-CSF in similar concentrations enhanced the defective bactericidal activity of PMNL from HIV-1-infected patients by ∼70%–150% and reached the baseline control PMNL killing. However, G-CSF enhanced neither phagocytosis nor fungicidal activity of normal PMNL against C. albicans blastoconidia. These data demonstrate that G-CSF enhances the antibacterial but not the antifungal activities of human PMNL in vitro and also improves the defective PMNLbactericidal activity of HIV-1-infected patients.</description><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Adult</subject><subject>AIDS-Related Complex - immunology</subject><subject>AIDS/HIV</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Analysis of Variance</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Blood Bactericidal Activity - physiology</subject><subject>Candida albicans</subject><subject>Candida albicans - immunology</subject><subject>Child</subject><subject>Colony stimulating factors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Fungi</subject><subject>Granulocyte Colony-Stimulating Factor - physiology</subject><subject>Granulocytes</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>In Vitro Techniques</subject><subject>Infections</subject><subject>Major Articles</subject><subject>Miscellaneous</subject><subject>Neutrophils</subject><subject>Neutrophils - physiology</subject><subject>Phagocytosis</subject><subject>Phagocytosis - physiology</subject><subject>Pretreatment</subject><subject>Reference Values</subject><subject>Regulatory factors and their cellular receptors</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - immunology</subject><subject>Superoxides</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFv0zAYRy0EGmVw54LkA-KWzvYX28lxlK1FqgoIkNAulus4q0cSd7aD6JH_HFcp25GTJb_3_S4PodeUzCmp4cINbePiBRUwhzmX9RM0oxxkIQSFp2hGCGMFrer6OXoR4x0hpAQhz9AZlaSsCczQn2XQw9h5c0gWL3znh0PxNbl-7HRywy2-1ib5gK-GnR6MjTjtLP6807fHA2ewHhr8Pis2OOMa3eFLk9wvlw7Yt3jjQ5-_js4H29ojsXg19nrAGzum4Pc718WX6Fmru2hfnd5z9P366ttiVaw_LT8uLteFKSuSCsmbRjIGDEBSJrncVoRTbWVtGgaNgVqWknJNBG01FYwZyTmzWyMBKkFaOEfvpt198PejjUn1LhrbdXqwfoyqIiVnWf2vSHnNCCc0i2QSTfAxBtuqfXC9DgdFiTrmUVMelfMoUDlPPnlz2h63vW0eD6Yemb89cR2N7tocx-SBf1pZSyIq-jhzF3OdBwyEMqCiyryYuIvJ_n7gOvxUQoLkavXjRm2gvlnzL0u1gr_Oq7KR</recordid><startdate>19910301</startdate><enddate>19910301</enddate><creator>Roilides, Emmanuel</creator><creator>Walsh, Thomas J.</creator><creator>Pizzo, Philip A.</creator><creator>Rubin, Marc</creator><general>University Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19910301</creationdate><title>Granulocyte Colony-Stimulating Factor Enhances the Phagocytic and Bactericidal Activity of Normal and Defective Human Neutrophils</title><author>Roilides, Emmanuel ; Walsh, Thomas J. ; Pizzo, Philip A. ; Rubin, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-75dd7223233712757b8051ae79cd23dc3974715a061fa1622c7552ebc733860f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Adult</topic><topic>AIDS-Related Complex - immunology</topic><topic>AIDS/HIV</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Analysis of Variance</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Blood Bactericidal Activity - physiology</topic><topic>Candida albicans</topic><topic>Candida albicans - immunology</topic><topic>Child</topic><topic>Colony stimulating factors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Fungi</topic><topic>Granulocyte Colony-Stimulating Factor - physiology</topic><topic>Granulocytes</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>In Vitro Techniques</topic><topic>Infections</topic><topic>Major Articles</topic><topic>Miscellaneous</topic><topic>Neutrophils</topic><topic>Neutrophils - physiology</topic><topic>Phagocytosis</topic><topic>Phagocytosis - physiology</topic><topic>Pretreatment</topic><topic>Reference Values</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - immunology</topic><topic>Superoxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roilides, Emmanuel</creatorcontrib><creatorcontrib>Walsh, Thomas J.</creatorcontrib><creatorcontrib>Pizzo, Philip A.</creatorcontrib><creatorcontrib>Rubin, Marc</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roilides, Emmanuel</au><au>Walsh, Thomas J.</au><au>Pizzo, Philip A.</au><au>Rubin, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulocyte Colony-Stimulating Factor Enhances the Phagocytic and Bactericidal Activity of Normal and Defective Human Neutrophils</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1991-03-01</date><risdate>1991</risdate><volume>163</volume><issue>3</issue><spage>579</spage><epage>583</epage><pages>579-583</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Granulocyte colony-stimulating factor (G-CSF) stimulates proliferation of myeloid cells and maybe a valuable adjunct in prevention and treatment of neutropenia-associated infections. Neutrophil (PMNL)phagocytic and microbicidal functions against Staphylococcus aureus and Candida albicans blastoconidia were therefore evaluated. Bacterial phagocytosis and bactericidal activity were significantly enhanced by ∼ 50%–70% after preincubation of normal PMNLw ith G-CSF in concentrations of 1000–4000 units/ml for 10 min at 37°C. G-CSF in similar concentrations enhanced the defective bactericidal activity of PMNL from HIV-1-infected patients by ∼70%–150% and reached the baseline control PMNL killing. However, G-CSF enhanced neither phagocytosis nor fungicidal activity of normal PMNL against C. albicans blastoconidia. These data demonstrate that G-CSF enhances the antibacterial but not the antifungal activities of human PMNL in vitro and also improves the defective PMNLbactericidal activity of HIV-1-infected patients.</abstract><cop>Chicago, IL</cop><pub>University Chicago Press</pub><pmid>1704903</pmid><doi>10.1093/infdis/163.3.579</doi><tpages>5</tpages></addata></record> |
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| subjects | Acquired Immunodeficiency Syndrome - immunology Adult AIDS-Related Complex - immunology AIDS/HIV Analysis of the immune response. Humoral and cellular immunity Analysis of Variance Bacteria Biological and medical sciences Blood Bactericidal Activity - physiology Candida albicans Candida albicans - immunology Child Colony stimulating factors Fundamental and applied biological sciences. Psychology Fundamental immunology Fungi Granulocyte Colony-Stimulating Factor - physiology Granulocytes Humans Immunobiology In Vitro Techniques Infections Major Articles Miscellaneous Neutrophils Neutrophils - physiology Phagocytosis Phagocytosis - physiology Pretreatment Reference Values Regulatory factors and their cellular receptors Staphylococcus aureus Staphylococcus aureus - immunology Superoxides |
| title | Granulocyte Colony-Stimulating Factor Enhances the Phagocytic and Bactericidal Activity of Normal and Defective Human Neutrophils |
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