Defective binding of 3-methylcholanthrene to the Ah receptor within C3H/1OT1/2 clone 8 mouse fibroblasts in culture

C3H/1OT1/2 clone 8 mouse fibroblasts (C3H/1OT1/2 cells) exhibit induction of aryl hydrocarbon hydroxylase (cytochrome P1-450) when exposed in culture to benzo(a)pyrene, benz(a)anthracene or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), but do not display the induction response when treated with 3-meth...

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Veröffentlicht in:	European journal of biochemistry 1983-05, Vol.132 (2), p.219-227
Hauptverfasser:	Okey, A B, Mason, M E, Gehly, E B, Heidelberger, C, Muncan, J, Dufresne, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benz(a)Anthracenes - metabolism Binding, Competitive Cell Nucleus - metabolism Cells, Cultured Clone Cells Cytosol - metabolism Fibroblasts - metabolism Methylcholanthrene - metabolism Mice Mice, Inbred C3H Polychlorinated Dibenzodioxins - metabolism Receptors, Aryl Hydrocarbon Receptors, Drug - metabolism
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