Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients
IT has been suggested that selected platelet-derived substances, such as serotonin (5-hydroxytryptamine) and thromboxane A 2 , may play an important part in the pathophysiology of certain acute coronary artery disease syndromes. 1 , 2 Specifically, increased concentrations of serotonin have been fou...
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| Veröffentlicht in: | The New England journal of medicine 1991-03, Vol.324 (10), p.641-648 |
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| container_title | The New England journal of medicine |
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| creator | Golino, Paolo Piscione, Federico Willerson, James T Cappelli-Bigazzi, Maurizio Focaccio, Amelia Villari, Bruno Indolfi, Ciro Russolillo, Enrico Condorelli, Mario Chiariello, Massimo |
| description | IT has been suggested that selected platelet-derived substances, such as serotonin (5-hydroxytryptamine) and thromboxane A
2
, may play an important part in the pathophysiology of certain acute coronary artery disease syndromes.
1
,
2
Specifically, increased concentrations of serotonin have been found in blood samples collected from the coronary sinus of patients with complex coronary-artery lesions.
3
Similarly, plasma from the coronary sinus of patients with severe coronary artery disease contains a humoral factor capable of constricting canine coronary arteries in vitro.
4
This vasoconstriction is prevented by serotonin-receptor antagonists.
4
In an experimental model of coronary-artery stenosis and endothelial injury, which is thought to . . . |
| doi_str_mv | 10.1056/NEJM199103073241001 |
| format | Article |
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2
, may play an important part in the pathophysiology of certain acute coronary artery disease syndromes.
1
,
2
Specifically, increased concentrations of serotonin have been found in blood samples collected from the coronary sinus of patients with complex coronary-artery lesions.
3
Similarly, plasma from the coronary sinus of patients with severe coronary artery disease contains a humoral factor capable of constricting canine coronary arteries in vitro.
4
This vasoconstriction is prevented by serotonin-receptor antagonists.
4
In an experimental model of coronary-artery stenosis and endothelial injury, which is thought to . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199103073241001</identifier><identifier>PMID: 1994246</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Angina pectoris ; Angiography ; Arteriosclerosis ; Atherosclerosis ; Blood flow ; Blood Flow Velocity - drug effects ; Blood platelets ; Body weight ; Cardiology ; Cardiovascular disease ; Catheters ; Coronary Angiography ; Coronary artery ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - pathology ; Coronary Artery Disease - physiopathology ; Coronary vessels ; Coronary Vessels - anatomy & histology ; Coronary Vessels - pathology ; Drug dosages ; Endothelium ; Endothelium, Vascular - drug effects ; Flow velocity ; Heart attacks ; Heart diseases ; Hemodynamics - drug effects ; Humans ; Internal medicine ; Intubation ; Ischemia ; Ketanserin ; Ketanserin - pharmacology ; Laboratories ; Medical imaging ; Medicine ; Middle Aged ; Patients ; Serotonin ; Serotonin - administration & dosage ; Serotonin - pharmacology ; Serotonin receptors ; Vasoconstriction - drug effects ; Vasodilation - drug effects</subject><ispartof>The New England journal of medicine, 1991-03, Vol.324 (10), p.641-648</ispartof><rights>Copyright Massachusetts Medical Society Mar 7, 1991</rights><rights>Copyright Massachusetts Medical Society, Publishing Division Mar 7, 1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-32d2cdb9d692c1ba84607757a279bd9c393cf9beaf88a3b4df6fc2f0e1e25f433</citedby><cites>FETCH-LOGICAL-c474t-32d2cdb9d692c1ba84607757a279bd9c393cf9beaf88a3b4df6fc2f0e1e25f433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199103073241001$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199103073241001$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1994246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Golino, Paolo</creatorcontrib><creatorcontrib>Piscione, Federico</creatorcontrib><creatorcontrib>Willerson, James T</creatorcontrib><creatorcontrib>Cappelli-Bigazzi, Maurizio</creatorcontrib><creatorcontrib>Focaccio, Amelia</creatorcontrib><creatorcontrib>Villari, Bruno</creatorcontrib><creatorcontrib>Indolfi, Ciro</creatorcontrib><creatorcontrib>Russolillo, Enrico</creatorcontrib><creatorcontrib>Condorelli, Mario</creatorcontrib><creatorcontrib>Chiariello, Massimo</creatorcontrib><title>Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>IT has been suggested that selected platelet-derived substances, such as serotonin (5-hydroxytryptamine) and thromboxane A
2
, may play an important part in the pathophysiology of certain acute coronary artery disease syndromes.
1
,
2
Specifically, increased concentrations of serotonin have been found in blood samples collected from the coronary sinus of patients with complex coronary-artery lesions.
3
Similarly, plasma from the coronary sinus of patients with severe coronary artery disease contains a humoral factor capable of constricting canine coronary arteries in vitro.
4
This vasoconstriction is prevented by serotonin-receptor antagonists.
4
In an experimental model of coronary-artery stenosis and endothelial injury, which is thought to . . .</description><subject>Adult</subject><subject>Angina pectoris</subject><subject>Angiography</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Blood flow</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood platelets</subject><subject>Body weight</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Catheters</subject><subject>Coronary Angiography</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - anatomy & histology</subject><subject>Coronary Vessels - pathology</subject><subject>Drug dosages</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Flow velocity</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Intubation</subject><subject>Ischemia</subject><subject>Ketanserin</subject><subject>Ketanserin - pharmacology</subject><subject>Laboratories</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Serotonin</subject><subject>Serotonin - administration & dosage</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin receptors</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasodilation - drug effects</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kctKJDEUhsOgaNszTyBCcMCNlJNbXbLsadsbjgrqukilEk1TlbRJWvEVfGrTlCiIThbJ4vzfx8k5AGxjdIBRXvy5mJ39w5xjRFFJCcMI4R9ghHNKM8ZQsQZGCJEqYyWnm2ArhDlKBzO-ATYSxggrRuDl0Dwqf6dshDOtlYwBOg2vlXfRWWOhs3DqvLPCP2cTH5V_hoemVzYYZwMUtoV_O-daeNS5J5jyVyKaJAvwycT7dxRO4n1SBtmtbjOAU2ejd9078hOsa9EF9evtHYPbo9nN9CQ7vzw-nU7OM8lKFjNKWiLbhrcFJxI3omIFKsu8FKTkTcsl5VRq3iihq0rQhrW60JJopLAiuWaUjsHe4F1497BUIda9CVJ1nbDKLUNdIcZywssU3P0UnLult6m3mhDKc5qn0Y_B7-9CmFeUEc7JSkWHlEz_D17peuFNnyZTY1Svlll_scxE7by5l02v2g9m2F6q7w_1vg-1VfP-v7ZXv0indw</recordid><startdate>19910307</startdate><enddate>19910307</enddate><creator>Golino, Paolo</creator><creator>Piscione, Federico</creator><creator>Willerson, James T</creator><creator>Cappelli-Bigazzi, Maurizio</creator><creator>Focaccio, Amelia</creator><creator>Villari, Bruno</creator><creator>Indolfi, Ciro</creator><creator>Russolillo, Enrico</creator><creator>Condorelli, Mario</creator><creator>Chiariello, Massimo</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19910307</creationdate><title>Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients</title><author>Golino, Paolo ; Piscione, Federico ; Willerson, James T ; Cappelli-Bigazzi, Maurizio ; Focaccio, Amelia ; Villari, Bruno ; Indolfi, Ciro ; Russolillo, Enrico ; Condorelli, Mario ; Chiariello, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-32d2cdb9d692c1ba84607757a279bd9c393cf9beaf88a3b4df6fc2f0e1e25f433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Angina pectoris</topic><topic>Angiography</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Blood flow</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood platelets</topic><topic>Body weight</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Catheters</topic><topic>Coronary Angiography</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary vessels</topic><topic>Coronary Vessels - anatomy & histology</topic><topic>Coronary Vessels - pathology</topic><topic>Drug dosages</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Flow velocity</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Intubation</topic><topic>Ischemia</topic><topic>Ketanserin</topic><topic>Ketanserin - pharmacology</topic><topic>Laboratories</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Serotonin</topic><topic>Serotonin - 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Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golino, Paolo</au><au>Piscione, Federico</au><au>Willerson, James T</au><au>Cappelli-Bigazzi, Maurizio</au><au>Focaccio, Amelia</au><au>Villari, Bruno</au><au>Indolfi, Ciro</au><au>Russolillo, Enrico</au><au>Condorelli, Mario</au><au>Chiariello, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1991-03-07</date><risdate>1991</risdate><volume>324</volume><issue>10</issue><spage>641</spage><epage>648</epage><pages>641-648</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>IT has been suggested that selected platelet-derived substances, such as serotonin (5-hydroxytryptamine) and thromboxane A
2
, may play an important part in the pathophysiology of certain acute coronary artery disease syndromes.
1
,
2
Specifically, increased concentrations of serotonin have been found in blood samples collected from the coronary sinus of patients with complex coronary-artery lesions.
3
Similarly, plasma from the coronary sinus of patients with severe coronary artery disease contains a humoral factor capable of constricting canine coronary arteries in vitro.
4
This vasoconstriction is prevented by serotonin-receptor antagonists.
4
In an experimental model of coronary-artery stenosis and endothelial injury, which is thought to . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>1994246</pmid><doi>10.1056/NEJM199103073241001</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1991-03, Vol.324 (10), p.641-648 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80445297 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Adult Angina pectoris Angiography Arteriosclerosis Atherosclerosis Blood flow Blood Flow Velocity - drug effects Blood platelets Body weight Cardiology Cardiovascular disease Catheters Coronary Angiography Coronary artery Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - pathology Coronary Artery Disease - physiopathology Coronary vessels Coronary Vessels - anatomy & histology Coronary Vessels - pathology Drug dosages Endothelium Endothelium, Vascular - drug effects Flow velocity Heart attacks Heart diseases Hemodynamics - drug effects Humans Internal medicine Intubation Ischemia Ketanserin Ketanserin - pharmacology Laboratories Medical imaging Medicine Middle Aged Patients Serotonin Serotonin - administration & dosage Serotonin - pharmacology Serotonin receptors Vasoconstriction - drug effects Vasodilation - drug effects |
| title | Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients |
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