Azathioprine treatment in a patient with HBsAg-positive acute viral hepatitis complicated by bridging necrosis
A patient with HBsAg-positive subacute hepatitis who presented a progressively deteriorating clinical condition was treated with azathioprine (100 mg/day) for eight months. Although the clinical symptoms disappeared and the biochemical abnormalities decreased, the disease nevertheless progressed to...
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| Veröffentlicht in: | Infection 1983-01, Vol.11 (1), p.31-32 |
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| container_title | Infection |
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| creator | Sagnelli, E Felaco, F M Pasquale, G Filippini, P Piccinino, F |
| description | A patient with HBsAg-positive subacute hepatitis who presented a progressively deteriorating clinical condition was treated with azathioprine (100 mg/day) for eight months. Although the clinical symptoms disappeared and the biochemical abnormalities decreased, the disease nevertheless progressed to chronic active hepatitis. Moreover, azathioprine favoured hepatitis B virus replication since titers of HBsAg, HBeAg and Dane-particle-associated core-antigen, as detected by radioimmunoassay, increased during treatment. In all, this drug was only of moderate use to our patient. |
| doi_str_mv | 10.1007/BF01651354 |
| format | Article |
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Although the clinical symptoms disappeared and the biochemical abnormalities decreased, the disease nevertheless progressed to chronic active hepatitis. Moreover, azathioprine favoured hepatitis B virus replication since titers of HBsAg, HBeAg and Dane-particle-associated core-antigen, as detected by radioimmunoassay, increased during treatment. 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Although the clinical symptoms disappeared and the biochemical abnormalities decreased, the disease nevertheless progressed to chronic active hepatitis. Moreover, azathioprine favoured hepatitis B virus replication since titers of HBsAg, HBeAg and Dane-particle-associated core-antigen, as detected by radioimmunoassay, increased during treatment. In all, this drug was only of moderate use to our patient.</description><subject>Adult</subject><subject>Azathioprine - therapeutic use</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - drug therapy</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B Antibodies - analysis</subject><subject>Hepatitis B Core Antigens - analysis</subject><subject>Hepatitis B e Antigens - analysis</subject><subject>Hepatitis B Surface Antigens - analysis</subject><subject>hepatitis B virus</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Necrosis</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9LwzAUx4Moc04v3oWcPAjVlyZpmuMczgkDL3ouSZtskf6ySSfzr7dlQ4-eHg8-7wvv80XomsA9ARAPj0sgCSeUsxM0JYzKCKSgp2gKFCBKSZycowvvPwCASyYmaJKkDNKET1E9_1Zh65q2c7XBoTMqVKYO2NVY4VYFNy5fLmzx6tHPN1HbeBfczmCV98HgnetUibdmJIPzOG-qtnS5CqbAeo9154qNqze4Nnk3XPpLdGZV6c3Vcc7Q-_LpbbGK1q_PL4v5OsopoSFSacwYcCpNUgjNihhSkcs41qk1nGpKY0WslsC1KDSPeWplYQW31OZW0QLoDN0ectuu-eyND1nlfG7KUtWm6X2WAmM8Fv-Dg1Qhk8HmDN0dwPER3xmbDcoq1e0zAtnYQvbXwgDfHFN7XZniFz1qpz-_O4Ml</recordid><startdate>198301</startdate><enddate>198301</enddate><creator>Sagnelli, E</creator><creator>Felaco, F M</creator><creator>Pasquale, G</creator><creator>Filippini, P</creator><creator>Piccinino, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198301</creationdate><title>Azathioprine treatment in a patient with HBsAg-positive acute viral hepatitis complicated by bridging necrosis</title><author>Sagnelli, E ; Felaco, F M ; Pasquale, G ; Filippini, P ; Piccinino, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-a82440539e6d7b4d2087c922b8fe53b332a1fb905b7db5258f9df75f3fcfa3d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Azathioprine - therapeutic use</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B - drug therapy</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B Antibodies - analysis</topic><topic>Hepatitis B Core Antigens - analysis</topic><topic>Hepatitis B e Antigens - analysis</topic><topic>Hepatitis B Surface Antigens - analysis</topic><topic>hepatitis B virus</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Necrosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sagnelli, E</creatorcontrib><creatorcontrib>Felaco, F M</creatorcontrib><creatorcontrib>Pasquale, G</creatorcontrib><creatorcontrib>Filippini, P</creatorcontrib><creatorcontrib>Piccinino, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sagnelli, E</au><au>Felaco, F M</au><au>Pasquale, G</au><au>Filippini, P</au><au>Piccinino, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Azathioprine treatment in a patient with HBsAg-positive acute viral hepatitis complicated by bridging necrosis</atitle><jtitle>Infection</jtitle><addtitle>Infection</addtitle><date>1983-01</date><risdate>1983</risdate><volume>11</volume><issue>1</issue><spage>31</spage><epage>32</epage><pages>31-32</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>A patient with HBsAg-positive subacute hepatitis who presented a progressively deteriorating clinical condition was treated with azathioprine (100 mg/day) for eight months. Although the clinical symptoms disappeared and the biochemical abnormalities decreased, the disease nevertheless progressed to chronic active hepatitis. Moreover, azathioprine favoured hepatitis B virus replication since titers of HBsAg, HBeAg and Dane-particle-associated core-antigen, as detected by radioimmunoassay, increased during treatment. In all, this drug was only of moderate use to our patient.</abstract><cop>Germany</cop><pmid>6840865</pmid><doi>10.1007/BF01651354</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 1983-01, Vol.11 (1), p.31-32 |
| issn | 0300-8126 1439-0973 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80445270 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Azathioprine - therapeutic use Hepatitis B - complications Hepatitis B - drug therapy Hepatitis B - immunology Hepatitis B Antibodies - analysis Hepatitis B Core Antigens - analysis Hepatitis B e Antigens - analysis Hepatitis B Surface Antigens - analysis hepatitis B virus Humans Liver - pathology Male Necrosis |
| title | Azathioprine treatment in a patient with HBsAg-positive acute viral hepatitis complicated by bridging necrosis |
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