The family of human Na,K-ATPase genes ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase
The multigene family of human Na,K-ATPase is composed of 5 α-subunit genes, 3 of which were shown to encode the functionally active α1, α2 and α3 isoforms of the catalytic subunit. This report describes the isolation, mapping and partial sequencing of the fourth gene ( ATP1AL1) that was demonstrated...
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| Veröffentlicht in: | FEBS letters 1991-01, Vol.278 (1), p.91-94 |
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| creator | Modyanov, N.N. Petrukhin, K.E. Sverdlov, V.E. Grishin, A.V. Orlova, M.Y. Kostina, M.B. Makarevich, O.I. Broude, N.E. Monastyrskaya, G.S. Sverdlov, E.D. |
| description | The multigene family of human Na,K-ATPase is composed of 5 α-subunit genes, 3 of which were shown to encode the functionally active α1, α2 and α3 isoforms of the catalytic subunit. This report describes the isolation, mapping and partial sequencing of the fourth gene (
ATP1AL1) that was demonstrated here to be functionally active and expressed in human brain and kidney. Limited DNA sequencing of the
ATP1AL1 exons allowed one to suggest that the gene probably encodes a new ion transport ATPase rather than an isoform of the Na,K-ATPase or the closely related H,K-ATPase. |
| doi_str_mv | 10.1016/0014-5793(91)80091-G |
| format | Article |
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ATP1AL1) that was demonstrated here to be functionally active and expressed in human brain and kidney. Limited DNA sequencing of the
ATP1AL1 exons allowed one to suggest that the gene probably encodes a new ion transport ATPase rather than an isoform of the Na,K-ATPase or the closely related H,K-ATPase.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(91)80091-G</identifier><identifier>PMID: 1847115</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adenosine Triphosphatases - genetics ; Adenosine Triphosphatases - metabolism ; Amino Acid Sequence ; Base Sequence ; Biological Transport ; Brain - enzymology ; Electrophoresis, Agar Gel ; Exons ; Gene family ; genes ; Human genome ; Humans ; Introns ; Ion transport ATPase ; Kidney - enzymology ; Molecular Sequence Data ; Multigene Family ; Na +,K +-ATPase ; Oligonucleotide Probes ; Polymerase Chain Reaction ; Sequence Homology, Nucleic Acid ; Sodium-Potassium-Exchanging ATPase - genetics ; Transcription, Genetic</subject><ispartof>FEBS letters, 1991-01, Vol.278 (1), p.91-94</ispartof><rights>1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-c66cd2c075f2fe10d684794d9d4a12f7efcf944f764412b5c3529dbb8e07e8a73</citedby><cites>FETCH-LOGICAL-c388t-c66cd2c075f2fe10d684794d9d4a12f7efcf944f764412b5c3529dbb8e07e8a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001457939180091G$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1847115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Modyanov, N.N.</creatorcontrib><creatorcontrib>Petrukhin, K.E.</creatorcontrib><creatorcontrib>Sverdlov, V.E.</creatorcontrib><creatorcontrib>Grishin, A.V.</creatorcontrib><creatorcontrib>Orlova, M.Y.</creatorcontrib><creatorcontrib>Kostina, M.B.</creatorcontrib><creatorcontrib>Makarevich, O.I.</creatorcontrib><creatorcontrib>Broude, N.E.</creatorcontrib><creatorcontrib>Monastyrskaya, G.S.</creatorcontrib><creatorcontrib>Sverdlov, E.D.</creatorcontrib><title>The family of human Na,K-ATPase genes ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The multigene family of human Na,K-ATPase is composed of 5 α-subunit genes, 3 of which were shown to encode the functionally active α1, α2 and α3 isoforms of the catalytic subunit. This report describes the isolation, mapping and partial sequencing of the fourth gene (
ATP1AL1) that was demonstrated here to be functionally active and expressed in human brain and kidney. Limited DNA sequencing of the
ATP1AL1 exons allowed one to suggest that the gene probably encodes a new ion transport ATPase rather than an isoform of the Na,K-ATPase or the closely related H,K-ATPase.</description><subject>Adenosine Triphosphatases - genetics</subject><subject>Adenosine Triphosphatases - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biological Transport</subject><subject>Brain - enzymology</subject><subject>Electrophoresis, Agar Gel</subject><subject>Exons</subject><subject>Gene family</subject><subject>genes</subject><subject>Human genome</subject><subject>Humans</subject><subject>Introns</subject><subject>Ion transport ATPase</subject><subject>Kidney - enzymology</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Na +,K +-ATPase</subject><subject>Oligonucleotide Probes</subject><subject>Polymerase Chain Reaction</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Sodium-Potassium-Exchanging ATPase - genetics</subject><subject>Transcription, Genetic</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcuOFCEUJUYz9oz-gSasjCaWcquoAjaTdCZOa-yoi3ZNKLg4mHoJtMl8gb8tPTXRna7I5Z4HnEPIM2BvgEH3ljHgVStU81LBK8mYgmr3gGxAiqZqeCcfks0fyGNyntJ3VmYJ6oycgeQCoN2QX4cbpN6MYbils6c3x9FM9JN5_bHaHr6YhPQbTphoGWC7h7uJhkRzNFOyMSw5zJMZCtnO44IZp0zN5OgS59705RonO7sikItNxMFkdLRQVoFljpmuPk_II2-GhE_vzwvy9frd4ep9tf-8-3C13Ve2kTJXtuusqy0Tra89AnNd-YjiTjluoPYCvfWKcy86zqHuW9u0tXJ9L5EJlEY0F-TFqlte-OOIKesxJIvDYCacj0lLxnnJrv4vEFrZciGbAuQr0MY5pYheLzGMJt5qYPpUlD61oE8taAX6rii9K7Tn9_rHfkT3l7Q2U_aX6x5LGj8DRp1sKGmiCxFt1m4O_zb4DQu6org</recordid><startdate>19910114</startdate><enddate>19910114</enddate><creator>Modyanov, N.N.</creator><creator>Petrukhin, K.E.</creator><creator>Sverdlov, V.E.</creator><creator>Grishin, A.V.</creator><creator>Orlova, M.Y.</creator><creator>Kostina, M.B.</creator><creator>Makarevich, O.I.</creator><creator>Broude, N.E.</creator><creator>Monastyrskaya, G.S.</creator><creator>Sverdlov, E.D.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T3</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19910114</creationdate><title>The family of human Na,K-ATPase genes ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase</title><author>Modyanov, N.N. ; Petrukhin, K.E. ; Sverdlov, V.E. ; Grishin, A.V. ; Orlova, M.Y. ; Kostina, M.B. ; Makarevich, O.I. ; Broude, N.E. ; Monastyrskaya, G.S. ; Sverdlov, E.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-c66cd2c075f2fe10d684794d9d4a12f7efcf944f764412b5c3529dbb8e07e8a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adenosine Triphosphatases - genetics</topic><topic>Adenosine Triphosphatases - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Biological Transport</topic><topic>Brain - enzymology</topic><topic>Electrophoresis, Agar Gel</topic><topic>Exons</topic><topic>Gene family</topic><topic>genes</topic><topic>Human genome</topic><topic>Humans</topic><topic>Introns</topic><topic>Ion transport ATPase</topic><topic>Kidney - enzymology</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Na +,K +-ATPase</topic><topic>Oligonucleotide Probes</topic><topic>Polymerase Chain Reaction</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Sodium-Potassium-Exchanging ATPase - genetics</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Modyanov, N.N.</creatorcontrib><creatorcontrib>Petrukhin, K.E.</creatorcontrib><creatorcontrib>Sverdlov, V.E.</creatorcontrib><creatorcontrib>Grishin, A.V.</creatorcontrib><creatorcontrib>Orlova, M.Y.</creatorcontrib><creatorcontrib>Kostina, M.B.</creatorcontrib><creatorcontrib>Makarevich, O.I.</creatorcontrib><creatorcontrib>Broude, N.E.</creatorcontrib><creatorcontrib>Monastyrskaya, G.S.</creatorcontrib><creatorcontrib>Sverdlov, E.D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Human Genome Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Modyanov, N.N.</au><au>Petrukhin, K.E.</au><au>Sverdlov, V.E.</au><au>Grishin, A.V.</au><au>Orlova, M.Y.</au><au>Kostina, M.B.</au><au>Makarevich, O.I.</au><au>Broude, N.E.</au><au>Monastyrskaya, G.S.</au><au>Sverdlov, E.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The family of human Na,K-ATPase genes ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1991-01-14</date><risdate>1991</risdate><volume>278</volume><issue>1</issue><spage>91</spage><epage>94</epage><pages>91-94</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The multigene family of human Na,K-ATPase is composed of 5 α-subunit genes, 3 of which were shown to encode the functionally active α1, α2 and α3 isoforms of the catalytic subunit. This report describes the isolation, mapping and partial sequencing of the fourth gene (
ATP1AL1) that was demonstrated here to be functionally active and expressed in human brain and kidney. Limited DNA sequencing of the
ATP1AL1 exons allowed one to suggest that the gene probably encodes a new ion transport ATPase rather than an isoform of the Na,K-ATPase or the closely related H,K-ATPase.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>1847115</pmid><doi>10.1016/0014-5793(91)80091-G</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1991-01, Vol.278 (1), p.91-94 |
| issn | 0014-5793 1873-3468 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Amino Acid Sequence Base Sequence Biological Transport Brain - enzymology Electrophoresis, Agar Gel Exons Gene family genes Human genome Humans Introns Ion transport ATPase Kidney - enzymology Molecular Sequence Data Multigene Family Na +,K +-ATPase Oligonucleotide Probes Polymerase Chain Reaction Sequence Homology, Nucleic Acid Sodium-Potassium-Exchanging ATPase - genetics Transcription, Genetic |
| title | The family of human Na,K-ATPase genes ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase |
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