Further evidence on the effect of vitamin E on the cholesterol distribution in lipoproteins with special reference to HDL subfractions
Earlier claims that oral administration of alpha-tocopherol results in significant and considerable increase in the serum total HDL concentration could not be substantiated. The present investigation does, however, show that lipoproteins are affected by alpha-tocopherol in other ways, the main effec...
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| Veröffentlicht in: | American journal of clinical pathology 1983-05, Vol.79 (5), p.604-606 |
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| container_title | American journal of clinical pathology |
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| creator | Serfontein, W J Ubbink, J B de Villiers, L S |
| description | Earlier claims that oral administration of alpha-tocopherol results in significant and considerable increase in the serum total HDL concentration could not be substantiated. The present investigation does, however, show that lipoproteins are affected by alpha-tocopherol in other ways, the main effects being an increase in LDL-cholesterol and also in the HDL3-V cholesterol, an HDL3-subfraction determined by polyacrylamide gel electrophoresis. The established lipoprotein risk indices (LDL/HDL and HDL3/HDL2 ratios) were unfavorably affected as a result of alpha-tocopherol treatment. It is concluded that on the basis of available evidence, there is no reason to believe that alpha-tocopherol has a role to play in the prevention and treatment of atherosclerotic disease. |
| doi_str_mv | 10.1093/ajcp/79.5.604 |
| format | Article |
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It is concluded that on the basis of available evidence, there is no reason to believe that alpha-tocopherol has a role to play in the prevention and treatment of atherosclerotic disease.</description><subject>Adult</subject><subject>Arteriosclerosis - drug therapy</subject><subject>Cholesterol - analysis</subject><subject>Cholesterol, HDL</subject><subject>Cholesterol, LDL</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Humans</subject><subject>Lipoproteins, HDL - analysis</subject><subject>Lipoproteins, HDL - blood</subject><subject>Lipoproteins, LDL - analysis</subject><subject>Male</subject><subject>Vitamin E - pharmacology</subject><subject>Vitamin E - therapeutic use</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1v2zAQhokiges6GTsW4JRNDr8kSmPhxk0AA12ameDHCWYgiSpJuegfyO8u3biZDuA9d_fyQegzJVtKOn6vX-x8L7ttvW2I-IDWtBO8kpKxK7QmhLCqo5J_RJ9SeiGEspaIFVo1LZc142v0ul9iPkLEcPIOJgs4TLg8YOh7sBmHHp981qOf8MP_lj2GAVKGGAbsfMrRmyX70izQ4Ocwx5DBTwn_9vmI0wzW6wFH6CH-u5ADfvx2wGkxfdT2PJlu0HWvhwS3l7pBz_uHn7vH6vDj-9Pu66GyrG1z1dRSSMeo6w2zQvK-diWnkMLIBpw1rXbMNKahUhLjWNO0oqsFr7UESkQr-Abdve0tGX8t5RNq9MnCMOgJwpJUscPLRFvA6g20MaRUsqs5-lHHP4oSdfauzt6V7FStivfCf7ksXswI7p2-iOZ_Af8wgUI</recordid><startdate>198305</startdate><enddate>198305</enddate><creator>Serfontein, W J</creator><creator>Ubbink, J B</creator><creator>de Villiers, L S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198305</creationdate><title>Further evidence on the effect of vitamin E on the cholesterol distribution in lipoproteins with special reference to HDL subfractions</title><author>Serfontein, W J ; Ubbink, J B ; de Villiers, L S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-65747d21dfb2c473f5deff474b76edcb8ad2b6b61770bd2668495435a7e104843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Arteriosclerosis - drug therapy</topic><topic>Cholesterol - analysis</topic><topic>Cholesterol, HDL</topic><topic>Cholesterol, LDL</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Humans</topic><topic>Lipoproteins, HDL - analysis</topic><topic>Lipoproteins, HDL - blood</topic><topic>Lipoproteins, LDL - analysis</topic><topic>Male</topic><topic>Vitamin E - pharmacology</topic><topic>Vitamin E - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serfontein, W J</creatorcontrib><creatorcontrib>Ubbink, J B</creatorcontrib><creatorcontrib>de Villiers, L S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serfontein, W J</au><au>Ubbink, J B</au><au>de Villiers, L S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further evidence on the effect of vitamin E on the cholesterol distribution in lipoproteins with special reference to HDL subfractions</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1983-05</date><risdate>1983</risdate><volume>79</volume><issue>5</issue><spage>604</spage><epage>606</epage><pages>604-606</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><abstract>Earlier claims that oral administration of alpha-tocopherol results in significant and considerable increase in the serum total HDL concentration could not be substantiated. 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| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1983-05, Vol.79 (5), p.604-606 |
| issn | 0002-9173 1943-7722 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80439548 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Arteriosclerosis - drug therapy Cholesterol - analysis Cholesterol, HDL Cholesterol, LDL Electrophoresis, Polyacrylamide Gel Humans Lipoproteins, HDL - analysis Lipoproteins, HDL - blood Lipoproteins, LDL - analysis Male Vitamin E - pharmacology Vitamin E - therapeutic use |
| title | Further evidence on the effect of vitamin E on the cholesterol distribution in lipoproteins with special reference to HDL subfractions |
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