Thrombin-platelet interactions: An assessment of the roles of saturable and nonsaturable binding in platelet activation

Thrombin binds to platelets and induces platelet activation, but the relationship of binding to activation is not clear. To better define this relationship, we have analyzed parameters of binding and activation by α-thrombin and by three analogous proteases that activate platelets somewhat different...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1983-04, Vol.222 (1), p.266-275
Hauptverfasser:	Alexander, Richard J., Fenton, John W., Detwiler, Thomas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Blood Platelets - metabolism Humans Peptide Hydrolases - metabolism Thrombin - metabolism Thrombin - pharmacology
Online-Zugang:	Volltext
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