A new class of HIV-1 specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

A series of novel acyclouridine derivatives substituted at both the C-5 and C-6 positions were synthesized for the purpose of improving the activity of a recently reported HIV-1-specific lead, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Preparation of C-6 substituted derivatives was ca...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1991-01, Vol.34 (1), p.349-357
Hauptverfasser:	Tanaka, Hiromichi, Baba, Masanori, Hayakawa, Hiroyuki, Sakamaki, Takashi, Miyasaka, Tadashi, Ubasawa, Masaru, Takashima, Hideaki, Sekiya, Kouichi, Nitta, Issei, Shigeta, Shiro, Walker, Richard T, Balzarini, Jan, De Clercq, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiviral Agents - chemical synthesis Carbohydrates. Nucleosides and nucleotides Cell Line Cell Survival - drug effects Chemistry Exact sciences and technology HIV-1 - drug effects Humans Indicators and Reagents Molecular Structure Nucleosides, nucleotides and oligonucleotides Organic chemistry Preparations and properties Structure-Activity Relationship Thymine - analogs & derivatives Thymine - chemical synthesis Thymine - chemistry Thymine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!