Photoaffinity label for the alpha 1-adrenergic receptor: synthesis and effects on membrane and affinity-purified receptors

An azide analog, 2-[4-(4-azidobenzoyl)piperazin-1-yl]-4-amino-6, 7-dimethoxyquinazoline (CP59,430), of the highly selective alpha 1-adrenergic receptor antagonist prazosin was synthesized and its effects on rat hepatic membrane and affinity-purified alpha 1-adrenergic receptor preparations were exam...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1983-04, Vol.80 (8), p.2102-2106
Hauptverfasser:	Hess, H J, Graham, R M, Homcy, C J
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Animals Azides - chemical synthesis Azides - metabolism Azides - pharmacology Cell Membrane - drug effects Liver - drug effects Photochemistry Prazosin Quinazolines - chemical synthesis Quinazolines - metabolism Quinazolines - pharmacology Rats Receptors, Adrenergic - drug effects Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - metabolism
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