Synergistic action of monoclonal antibodies directed at p55 and p75 chains of the human IL-2-receptor

TU27, a mouse IgG1 mAb directed at the p75 chain of the human IL-2R, was analyzed for its ability to interact with IL-2 binding on isolated p75 chains (YT-2C2 cells) and high affinity p55/p75 receptors (human alloreactive T cell clone 4AS), to inhibit IL-2-induced proliferation (4AS cells) and to co...

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Veröffentlicht in:	The Journal of immunology (1950) 1991-02, Vol.146 (3), p.884-892
Hauptverfasser:	Audrain, M, Boeffard, F, Soulillou, JP, Jacques, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal - immunology Biological and medical sciences Cell Division - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interleukin-2 - metabolism Interleukin-2 - pharmacology Lymphocyte Activation Lymphokines, interleukins ( function, expression) Lymphoma - immunology Receptors, Interleukin-2 - analysis Receptors, Interleukin-2 - immunology Regulatory factors and their cellular receptors T-Lymphocytes - immunology
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