G-proteins mediate intestinal chloride channel activation

The localization of several GTP-binding regulatory proteins in teh apical membrane of intestinal epithelial cells has prompted us to investigate a possible role for G-proteins as modulators of apical Cl- channels. In membrane vesicles isolated from rat small intestine or human HT29-cl.19A colon carc...

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Veröffentlicht in:	The Journal of biological chemistry 1991-02, Vol.266 (4), p.2036-2040
Hauptverfasser:	TILLY, B. C, KANSEN, M, VAN GAGELDONK, P. G. M, VAN DEN BERGHE, N, GALJAARD, H, BIJMAN, J, DE JONGE, H. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Membrane - metabolism Cell physiology chloride Chloride Channels Chlorides - metabolism Colonic Neoplasms Epithelium - metabolism Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism guanine nucleotide-binding protein Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Humans Intestinal Mucosa - metabolism Ion Channels - metabolism Kinetics Membrane and intracellular transports Membrane Proteins - metabolism Molecular and cellular biology Potassium Channels - metabolism Rats Tumor Cells, Cultured Valinomycin - pharmacology
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