Pharmacokinetic Disposition of Zidovudine during Pregnancy

Zidovudine pharmacokinetics was determined in three human immunodeficiency virus type I-seropositive women receiving zidovudine (200 mg orally every 4 h) from 19 to 39 weeks ofpregnancy and postpartum. Zidovudine concentrations were measured using high-pressure liquid chromatography, and pharmacokin...

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Veröffentlicht in:	The Journal of infectious diseases 1991-02, Vol.163 (2), p.226-232
Hauptverfasser:	Watts, D. Heather, Brown, Zane A., Tartaglione, Teresa, Burchett, Sandra K., Opheim, Kent, Coombs, Robert, Corey, Lawrence
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antigens Antiviral agents Biological and medical sciences Blood Blood plasma Chromatography, High Pressure Liquid Dosage Female Fetal Blood - chemistry Half lives Half-Life HIV HIV Infections - metabolism HIV Infections - prevention & control Humans Infant, Newborn Infants Major Articles Medical sciences Pharmacokinetics Pharmacology. Drug treatments Postpartum Period - metabolism Pregnancy Pregnancy - metabolism Pregnancy Complications, Infectious - metabolism Zidovudine - pharmacokinetics Zidovudine - therapeutic use
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