Cocaethylene: A Unique Cocaine Metabolite Displays High Affinity for the Dopamine Transporter

: Concurrent cocaine and alcohol use is common practice in the general population, as indicated by recent prevalence studies. In the presence of ethyl alcohol, cocaine is metabolized to its ethyl homolog, cocaethylene. The transesterification of cocaine and ethanol to cocaethylene takes place in the...

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Veröffentlicht in:	Journal of neurochemistry 1991-02, Vol.56 (2), p.698-701
Hauptverfasser:	Hearn, W. Lee, Flynn, Donna D., Hime, George W., Rose, Stefan, Cofino, Julio C., Mantero‐Atienza, Emilio, Wetli, Charles V., Mash, Deborah C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Brain - metabolism Carrier Proteins - metabolism CNS Cocaine Cocaine - analogs & derivatives Cocaine - blood Cocaine - metabolism Dopamine Plasma Membrane Transport Proteins Drug addictions Esterification Ethanol Ethanol - blood Ethanol - metabolism Female Humans Liver - metabolism Male Mazindol - metabolism Medical sciences Membrane Glycoproteins Membrane Transport Proteins Monoamine uptake sites Nerve Tissue Proteins Toxicology
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