Plasma lecithin-cholesterol acyltransferase activity and plasma lipoprotein composition and concentrations in kwashiorkor
Plasma lecithin-cholesterol acyltransferase (LCAT) activity, lipoprotein composition, and lipoprotein concentrations were measured in 21 children with kwashiorkor before (day 1), during (day 10), and after treatment (day 30). Day 1 LCAT activity (78.2 µmol · L−1 · h−1) was decreased with respect to...
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| Veröffentlicht in: | The American journal of clinical nutrition 1991-02, Vol.53 (2), p.512-519 |
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| description | Plasma lecithin-cholesterol acyltransferase (LCAT) activity, lipoprotein composition, and lipoprotein concentrations were measured in 21 children with kwashiorkor before (day 1), during (day 10), and after treatment (day 30). Day 1 LCAT activity (78.2 µmol · L−1 · h−1) was decreased with respect to day 10 (139.2 µmol · L−1 · h−1, P < 0.001) and day 30 (108.0 µmol · L−1 · h−1, P = 0.08). Plasma total cholesterol (TC), cholesterol ester (CE), and lipoprotein CEs (VLDL, IDL, LDL, and HDL) were reduced relative to days 10 and 30 (P < 0.001). Before treatment HDL composition was abnormal. On days 1, 10, and 30, the respective mean HDL-apolipoprotein A-I (apo A-I) concentrations were 23.33, 39.66, and 36.08 µmol/L. LDL-apo B concentrations were 0.40, 0.68, and 0.56 µmol/L (P < 0.01, days 10 and 30 vs day 1). LDL particles on day 1 were decreased in number, depleted of CE, and laden with triacylglycerol and surface lipids. LCAT activity on day 1 correlated with LDL-CE linoleate (P < 0.05, r = 0.48). Reduced plasma LCAT activity is an important factor related to abnormalities in lipoprotein composition and concentrations. |
| doi_str_mv | 10.1093/ajcn/53.2.512 |
| format | Article |
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Day 1 LCAT activity (78.2 µmol · L−1 · h−1) was decreased with respect to day 10 (139.2 µmol · L−1 · h−1, P &lt; 0.001) and day 30 (108.0 µmol · L−1 · h−1, P = 0.08). Plasma total cholesterol (TC), cholesterol ester (CE), and lipoprotein CEs (VLDL, IDL, LDL, and HDL) were reduced relative to days 10 and 30 (P &lt; 0.001). Before treatment HDL composition was abnormal. On days 1, 10, and 30, the respective mean HDL-apolipoprotein A-I (apo A-I) concentrations were 23.33, 39.66, and 36.08 µmol/L. LDL-apo B concentrations were 0.40, 0.68, and 0.56 µmol/L (P &lt; 0.01, days 10 and 30 vs day 1). LDL particles on day 1 were decreased in number, depleted of CE, and laden with triacylglycerol and surface lipids. LCAT activity on day 1 correlated with LDL-CE linoleate (P &lt; 0.05, r = 0.48). Reduced plasma LCAT activity is an important factor related to abnormalities in lipoprotein composition and concentrations.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/53.2.512</identifier><identifier>PMID: 1989419</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>ACILTRANSFERASA ; ACYLTRANSFERASE ; apo A-I ; apo A-II ; apo B ; Apolipoproteins B - blood ; BEBES ; Biological and medical sciences ; Child, Preschool ; CHOLESTEROL ; Cholesterol - blood ; Cholesterol Esters - blood ; COLESTEROL ; ENFANT ; ENFANT EN BAS AGE ; ENFERMEDADES CARENCIALES ; Fatty Acids - blood ; Fatty Acids - classification ; Humans ; Infant ; kwashiorkor ; Kwashiorkor - blood ; Kwashiorkor - metabolism ; Lecithin-cholesterol acyltransferase ; lipoprotein composition ; lipoprotein concentration ; LIPOPROTEINAS ; LIPOPROTEINE ; Lipoproteins - blood ; Lipoproteins, HDL - blood ; MALADIE DE CARENCE ; Medical sciences ; Metabolic diseases ; NINOS ; Osmolar Concentration ; Phosphatidylcholine-Sterol O-Acyltransferase - metabolism ; Phosphatidylcholines - blood ; PLASMA SANGUIN ; PLASMA SANGUINEO ; Sphingomyelins - blood</subject><ispartof>The American journal of clinical nutrition, 1991-02, Vol.53 (2), p.512-519</ispartof><rights>1991 American Society for Nutrition.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-8e016a166a092661648dc176e12b29b9ea977b4cbe6782367fe733baa1ba96603</citedby><cites>FETCH-LOGICAL-c423t-8e016a166a092661648dc176e12b29b9ea977b4cbe6782367fe733baa1ba96603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5107223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1989419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhansay, MA</creatorcontrib><creatorcontrib>Benadé, AJ</creatorcontrib><creatorcontrib>Donald, PR</creatorcontrib><title>Plasma lecithin-cholesterol acyltransferase activity and plasma lipoprotein composition and concentrations in kwashiorkor</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Plasma lecithin-cholesterol acyltransferase (LCAT) activity, lipoprotein composition, and lipoprotein concentrations were measured in 21 children with kwashiorkor before (day 1), during (day 10), and after treatment (day 30). Day 1 LCAT activity (78.2 µmol · L−1 · h−1) was decreased with respect to day 10 (139.2 µmol · L−1 · h−1, P &lt; 0.001) and day 30 (108.0 µmol · L−1 · h−1, P = 0.08). Plasma total cholesterol (TC), cholesterol ester (CE), and lipoprotein CEs (VLDL, IDL, LDL, and HDL) were reduced relative to days 10 and 30 (P &lt; 0.001). Before treatment HDL composition was abnormal. On days 1, 10, and 30, the respective mean HDL-apolipoprotein A-I (apo A-I) concentrations were 23.33, 39.66, and 36.08 µmol/L. LDL-apo B concentrations were 0.40, 0.68, and 0.56 µmol/L (P &lt; 0.01, days 10 and 30 vs day 1). LDL particles on day 1 were decreased in number, depleted of CE, and laden with triacylglycerol and surface lipids. LCAT activity on day 1 correlated with LDL-CE linoleate (P &lt; 0.05, r = 0.48). Reduced plasma LCAT activity is an important factor related to abnormalities in lipoprotein composition and concentrations.</description><subject>ACILTRANSFERASA</subject><subject>ACYLTRANSFERASE</subject><subject>apo A-I</subject><subject>apo A-II</subject><subject>apo B</subject><subject>Apolipoproteins B - blood</subject><subject>BEBES</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>CHOLESTEROL</subject><subject>Cholesterol - blood</subject><subject>Cholesterol Esters - blood</subject><subject>COLESTEROL</subject><subject>ENFANT</subject><subject>ENFANT EN BAS AGE</subject><subject>ENFERMEDADES CARENCIALES</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids - classification</subject><subject>Humans</subject><subject>Infant</subject><subject>kwashiorkor</subject><subject>Kwashiorkor - blood</subject><subject>Kwashiorkor - metabolism</subject><subject>Lecithin-cholesterol acyltransferase</subject><subject>lipoprotein composition</subject><subject>lipoprotein concentration</subject><subject>LIPOPROTEINAS</subject><subject>LIPOPROTEINE</subject><subject>Lipoproteins - blood</subject><subject>Lipoproteins, HDL - blood</subject><subject>MALADIE DE CARENCE</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>NINOS</subject><subject>Osmolar Concentration</subject><subject>Phosphatidylcholine-Sterol O-Acyltransferase - metabolism</subject><subject>Phosphatidylcholines - blood</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>Sphingomyelins - blood</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtv1DAURi1EVYbCkg0SUhaIXaZ-JH4sUcVLqtRK0LV149wwbp042Jmi-ff1kBGsWFn2d3z13UPIG0a3jBpxCfduumzFlm9bxp-RDTNC14JT9ZxsKKW8Nky2L8jLnO8pZbzR8pycM6NNw8yGHG4D5BGqgM4vOz_VbhcD5gVTDBW4Q1gSTHnABBnLffGPfjlUMPXVfPro5zinuKCfKhfHOWa_-Dj9QVycHE5lwvElV4V4-A1552N6iOkVORsgZHx9Oi_I3edPP66-1tc3X75dfbyuXcPFUmukTAKTEqjhUjLZ6N4xJZHxjpvOIBilusZ1KJXmQqoBlRAdAOvASEnFBfmwzi0tf-3Lanb02WEIMGHcZ6tpw5WWuoD1CroUc0442Dn5EdLBMmqPqu1RtW2F5baoLvy70-B9N2L_j17dlvz9KYfsIAxFpPP5L9YyqjgXBXu7YgNECz9TQe6-G8aahh_LqzXEYujRY7LZeSxWe5_QLbaP_j_tngAqEaVi</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>Dhansay, MA</creator><creator>Benadé, AJ</creator><creator>Donald, PR</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910201</creationdate><title>Plasma lecithin-cholesterol acyltransferase activity and plasma lipoprotein composition and concentrations in kwashiorkor</title><author>Dhansay, MA ; Benadé, AJ ; Donald, PR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-8e016a166a092661648dc176e12b29b9ea977b4cbe6782367fe733baa1ba96603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>ACILTRANSFERASA</topic><topic>ACYLTRANSFERASE</topic><topic>apo A-I</topic><topic>apo A-II</topic><topic>apo B</topic><topic>Apolipoproteins B - blood</topic><topic>BEBES</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>CHOLESTEROL</topic><topic>Cholesterol - blood</topic><topic>Cholesterol Esters - blood</topic><topic>COLESTEROL</topic><topic>ENFANT</topic><topic>ENFANT EN BAS AGE</topic><topic>ENFERMEDADES CARENCIALES</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids - classification</topic><topic>Humans</topic><topic>Infant</topic><topic>kwashiorkor</topic><topic>Kwashiorkor - blood</topic><topic>Kwashiorkor - metabolism</topic><topic>Lecithin-cholesterol acyltransferase</topic><topic>lipoprotein composition</topic><topic>lipoprotein concentration</topic><topic>LIPOPROTEINAS</topic><topic>LIPOPROTEINE</topic><topic>Lipoproteins - blood</topic><topic>Lipoproteins, HDL - blood</topic><topic>MALADIE DE CARENCE</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>NINOS</topic><topic>Osmolar Concentration</topic><topic>Phosphatidylcholine-Sterol O-Acyltransferase - metabolism</topic><topic>Phosphatidylcholines - blood</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>Sphingomyelins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dhansay, MA</creatorcontrib><creatorcontrib>Benadé, AJ</creatorcontrib><creatorcontrib>Donald, PR</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhansay, MA</au><au>Benadé, AJ</au><au>Donald, PR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma lecithin-cholesterol acyltransferase activity and plasma lipoprotein composition and concentrations in kwashiorkor</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>53</volume><issue>2</issue><spage>512</spage><epage>519</epage><pages>512-519</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Plasma lecithin-cholesterol acyltransferase (LCAT) activity, lipoprotein composition, and lipoprotein concentrations were measured in 21 children with kwashiorkor before (day 1), during (day 10), and after treatment (day 30). Day 1 LCAT activity (78.2 µmol · L−1 · h−1) was decreased with respect to day 10 (139.2 µmol · L−1 · h−1, P &lt; 0.001) and day 30 (108.0 µmol · L−1 · h−1, P = 0.08). Plasma total cholesterol (TC), cholesterol ester (CE), and lipoprotein CEs (VLDL, IDL, LDL, and HDL) were reduced relative to days 10 and 30 (P &lt; 0.001). Before treatment HDL composition was abnormal. On days 1, 10, and 30, the respective mean HDL-apolipoprotein A-I (apo A-I) concentrations were 23.33, 39.66, and 36.08 µmol/L. LDL-apo B concentrations were 0.40, 0.68, and 0.56 µmol/L (P &lt; 0.01, days 10 and 30 vs day 1). LDL particles on day 1 were decreased in number, depleted of CE, and laden with triacylglycerol and surface lipids. LCAT activity on day 1 correlated with LDL-CE linoleate (P &lt; 0.05, r = 0.48). Reduced plasma LCAT activity is an important factor related to abnormalities in lipoprotein composition and concentrations.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>1989419</pmid><doi>10.1093/ajcn/53.2.512</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of clinical nutrition, 1991-02, Vol.53 (2), p.512-519 |
| issn | 0002-9165 1938-3207 |
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| subjects | ACILTRANSFERASA ACYLTRANSFERASE apo A-I apo A-II apo B Apolipoproteins B - blood BEBES Biological and medical sciences Child, Preschool CHOLESTEROL Cholesterol - blood Cholesterol Esters - blood COLESTEROL ENFANT ENFANT EN BAS AGE ENFERMEDADES CARENCIALES Fatty Acids - blood Fatty Acids - classification Humans Infant kwashiorkor Kwashiorkor - blood Kwashiorkor - metabolism Lecithin-cholesterol acyltransferase lipoprotein composition lipoprotein concentration LIPOPROTEINAS LIPOPROTEINE Lipoproteins - blood Lipoproteins, HDL - blood MALADIE DE CARENCE Medical sciences Metabolic diseases NINOS Osmolar Concentration Phosphatidylcholine-Sterol O-Acyltransferase - metabolism Phosphatidylcholines - blood PLASMA SANGUIN PLASMA SANGUINEO Sphingomyelins - blood |
| title | Plasma lecithin-cholesterol acyltransferase activity and plasma lipoprotein composition and concentrations in kwashiorkor |
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