Age‐Dependence of the IgA Anti‐α(1→3) Dextran B1355 Response in Vitro
The magnitude of the Balb/c mouse IgA anti‐α(1→3) dextran B1355 (anti‐dex) response in vivo was recently found to be markedly T‐cell‐dependent and age‐dependent. This report demonstrates that the in vitro IgA anti‐dex response by mesenteric lymph nodes (MLN) is highly age‐dependent and that there is...
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| Veröffentlicht in: | Scandinavian journal of immunology 1983-02, Vol.17 (2), p.115-121 |
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| container_title | Scandinavian journal of immunology |
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| creator | RIVIER, D. A. TREFTS, P. E. KAGNOFF, M. F. |
| description | The magnitude of the Balb/c mouse IgA anti‐α(1→3) dextran B1355 (anti‐dex) response in vivo was recently found to be markedly T‐cell‐dependent and age‐dependent. This report demonstrates that the in vitro IgA anti‐dex response by mesenteric lymph nodes (MLN) is highly age‐dependent and that there is an age‐dependent increase of the background IgA anti‐dex plaque‐forming cell (PFC) response occurring in the absence of added antigen which correlates significantly with the magnitude of the antigen‐stimulated response. In aging mice both background and antigen‐stimulated IgA anti‐dex responses appeared to be significantly higher in MLN than in spleen cultures. Moreover, it is shown that there is a striking increase with age of natural antibody in the serum of normal Balb/c to α(1→3) film‐in determinants, particularly IgA and lesser amounts of IgM and IgG3. |
| doi_str_mv | 10.1111/j.1365-3083.1983.tb00773.x |
| format | Article |
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A.</creatorcontrib><creatorcontrib>TREFTS, P. E.</creatorcontrib><creatorcontrib>KAGNOFF, M. F.</creatorcontrib><title>Age‐Dependence of the IgA Anti‐α(1→3) Dextran B1355 Response in Vitro</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>The magnitude of the Balb/c mouse IgA anti‐α(1→3) dextran B1355 (anti‐dex) response in vivo was recently found to be markedly T‐cell‐dependent and age‐dependent. This report demonstrates that the in vitro IgA anti‐dex response by mesenteric lymph nodes (MLN) is highly age‐dependent and that there is an age‐dependent increase of the background IgA anti‐dex plaque‐forming cell (PFC) response occurring in the absence of added antigen which correlates significantly with the magnitude of the antigen‐stimulated response. In aging mice both background and antigen‐stimulated IgA anti‐dex responses appeared to be significantly higher in MLN than in spleen cultures. Moreover, it is shown that there is a striking increase with age of natural antibody in the serum of normal Balb/c to α(1→3) film‐in determinants, particularly IgA and lesser amounts of IgM and IgG3.</description><subject>Aging</subject><subject>Animals</subject><subject>Antibody-Producing Cells - immunology</subject><subject>Cells, Cultured</subject><subject>Dextrans - immunology</subject><subject>Hemolytic Plaque Technique</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Lymph Nodes - cytology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Spleen - cytology</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1OwzAQhS0EKqVwBCSLBYJFytiOY4cFUmn5KaqExN_WcpMJpGqTEqei3bFijbgJF-EQPQmpWnWLmMXM4r03o_kIOWDQZFWdDJpMBNIToEWThVUr-wBKieZ0g9TX0iapgwDwQl_JbbLj3ACACa5EjdQCpjUHVie91jPO3z87OMYsxixCmie0fEHafW7RVlamlfjzfcTmH1_imHZwWhY2o-dMSEnv0I3zzCFNM_qUlkW-S7YSO3S4t5oN8nh58dC-9nq3V912q-dFgknpWZ7EkiVSCc6FnyiuIujbUEomdSACH2MBEVg_iThYqftxYAMMlOLaj3iiUTTI4XLvuMhfJ-hKM0pdhMOhzTCfOKPB50Eo_T-N1RtahSFUxtOlMSpy5wpMzLhIR7aYGQZmwdwMzAKsWYA1C-ZmxdxMq_D-6sqkP8J4HV1BrvSzpf6WDnH2j83m_qbLmBS_eWmRBw</recordid><startdate>198302</startdate><enddate>198302</enddate><creator>RIVIER, D. 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F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3155-a2fd51f5732234f727c0ba9551586364ed30c0a4fc20a58bd6a6e677284c2f8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Antibody-Producing Cells - immunology</topic><topic>Cells, Cultured</topic><topic>Dextrans - immunology</topic><topic>Hemolytic Plaque Technique</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Lymph Nodes - cytology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Spleen - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIVIER, D. A.</creatorcontrib><creatorcontrib>TREFTS, P. E.</creatorcontrib><creatorcontrib>KAGNOFF, M. 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F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age‐Dependence of the IgA Anti‐α(1→3) Dextran B1355 Response in Vitro</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>1983-02</date><risdate>1983</risdate><volume>17</volume><issue>2</issue><spage>115</spage><epage>121</epage><pages>115-121</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>The magnitude of the Balb/c mouse IgA anti‐α(1→3) dextran B1355 (anti‐dex) response in vivo was recently found to be markedly T‐cell‐dependent and age‐dependent. This report demonstrates that the in vitro IgA anti‐dex response by mesenteric lymph nodes (MLN) is highly age‐dependent and that there is an age‐dependent increase of the background IgA anti‐dex plaque‐forming cell (PFC) response occurring in the absence of added antigen which correlates significantly with the magnitude of the antigen‐stimulated response. In aging mice both background and antigen‐stimulated IgA anti‐dex responses appeared to be significantly higher in MLN than in spleen cultures. Moreover, it is shown that there is a striking increase with age of natural antibody in the serum of normal Balb/c to α(1→3) film‐in determinants, particularly IgA and lesser amounts of IgM and IgG3.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6188201</pmid><doi>10.1111/j.1365-3083.1983.tb00773.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9475 |
| ispartof | Scandinavian journal of immunology, 1983-02, Vol.17 (2), p.115-121 |
| issn | 0300-9475 1365-3083 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aging Animals Antibody-Producing Cells - immunology Cells, Cultured Dextrans - immunology Hemolytic Plaque Technique Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Lymph Nodes - cytology Mice Mice, Inbred BALB C Spleen - cytology |
| title | Age‐Dependence of the IgA Anti‐α(1→3) Dextran B1355 Response in Vitro |
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