Immunosuppression and the Risk of Brain Lymphoma

To the Editor: The greatly increased incidence of lymphomas in circumstances of immunosuppression and their frequent location in the brain are well documented 1 2 3 and now extended to cases of AIDS. 4 The phenomenon remains unexplained. Kinlen 3 remarks that the explanation is "elusive";...

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Veröffentlicht in:	The New England journal of medicine 1983-05, Vol.308 (18), p.1099-1100
1. Verfasser:	Kay, H E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications AIDS/HIV Brain Neoplasms - etiology Humans Immunosuppressive Agents - adverse effects Lymphoma - etiology Risk
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	To the Editor: The greatly increased incidence of lymphomas in circumstances of immunosuppression and their frequent location in the brain are well documented 1 2 3 and now extended to cases of AIDS. 4 The phenomenon remains unexplained. Kinlen 3 remarks that the explanation is "elusive"; Penn 1 concludes his review with questions: "Could neurotropic herpes viruses be responsible?" "Are the microglia in the CNS [central nervous system] more prone to various lymphomagenic stimuli than lymphocytes elsewhere in the body?" Whereas spontaneous lymphomas rarely affect the brain (
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198305053081814