Variant human breast tumor estrogen receptor with constitutive transcriptional activity

Since progesterone receptor (PgR) is normally induced by estrogen, breast cancer lacking estrogen receptor (ER) would also be expected to lack PgR. However, a small percentage of breast cancers are ER- yet PgR+. These tumors might possess an ER which is defective in estrogen binding but is still fun...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1991, Vol.51 (1), p.105-109
Hauptverfasser:	FUQUA, S. A. W, FITZGERALD, S. D, CHAMNESS, G. C, TANDON, A. K, MCDONNELL, D. P, NAWAZ, Z, O'MALLEY, B. W, MCGUIRE, W. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Blotting, Western Breast Neoplasms - genetics Cloning, Molecular Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Molecular Sequence Data Polymerase Chain Reaction Receptors, Estrogen - genetics Receptors, Estrogen - immunology Receptors, Progesterone - genetics Recombinant Proteins - immunology RNA, Messenger - genetics RNA, Neoplasm - genetics Transcription, Genetic Tumors
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