Purification of a glucagon releasing factor from the rat hypothalamus
The purification of a peptide from the rat hypothalamus which is capable of stimulating the release of glucagon from the endocrine pancreas and therefore named glucagon releasing factor (G1RF), is described. Compositional analysis of the product obtained using well established techniques for peptide...
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| Veröffentlicht in: | Life sciences (1973) 1983-03, Vol.32 (11), p.1271-1278 |
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| container_end_page | 1278 |
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| container_issue | 11 |
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| container_title | Life sciences (1973) |
| container_volume | 32 |
| creator | Moltz, J.H. Fawcett, C.P. |
| description | The purification of a peptide from the rat hypothalamus which is capable of stimulating the release of glucagon from the endocrine pancreas and therefore named glucagon releasing factor (G1RF), is described. Compositional analysis of the product obtained using well established techniques for peptide isolation revealed that G1RF appeared to consist of 30–31 amino acids. The significance of G1RF in the physiological regulation of glucagon secretion is yet to be determined but the existence of this very potent factor supports the concept of a hypothalamic-pancreatic neurohormonal link. |
| doi_str_mv | 10.1016/0024-3205(83)90197-2 |
| format | Article |
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Compositional analysis of the product obtained using well established techniques for peptide isolation revealed that G1RF appeared to consist of 30–31 amino acids. The significance of G1RF in the physiological regulation of glucagon secretion is yet to be determined but the existence of this very potent factor supports the concept of a hypothalamic-pancreatic neurohormonal link.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(83)90197-2</identifier><identifier>PMID: 6339852</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Chromatography, Gel ; Chromatography, Ion Exchange ; Glucagon - metabolism ; glucagon releasing hormone ; Hypothalamic Hormones - isolation & purification ; Hypothalamic Hormones - pharmacology ; hypothalamus ; Hypothalamus - analysis ; Islets of Langerhans - metabolism ; Median Eminence - analysis ; Peptides ; Rats</subject><ispartof>Life sciences (1973), 1983-03, Vol.32 (11), p.1271-1278</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-487d209ff403424907bfd715d17d0069c060a8d92811cd8094d61a98367ef123</citedby><cites>FETCH-LOGICAL-c388t-487d209ff403424907bfd715d17d0069c060a8d92811cd8094d61a98367ef123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0024320583901972$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6339852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moltz, J.H.</creatorcontrib><creatorcontrib>Fawcett, C.P.</creatorcontrib><title>Purification of a glucagon releasing factor from the rat hypothalamus</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The purification of a peptide from the rat hypothalamus which is capable of stimulating the release of glucagon from the endocrine pancreas and therefore named glucagon releasing factor (G1RF), is described. Compositional analysis of the product obtained using well established techniques for peptide isolation revealed that G1RF appeared to consist of 30–31 amino acids. The significance of G1RF in the physiological regulation of glucagon secretion is yet to be determined but the existence of this very potent factor supports the concept of a hypothalamic-pancreatic neurohormonal link.</description><subject>Animals</subject><subject>Chromatography, Gel</subject><subject>Chromatography, Ion Exchange</subject><subject>Glucagon - metabolism</subject><subject>glucagon releasing hormone</subject><subject>Hypothalamic Hormones - isolation & purification</subject><subject>Hypothalamic Hormones - pharmacology</subject><subject>hypothalamus</subject><subject>Hypothalamus - analysis</subject><subject>Islets of Langerhans - metabolism</subject><subject>Median Eminence - analysis</subject><subject>Peptides</subject><subject>Rats</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVb_gcKeRA-rk2R3k1wEKfUDCnroPaT5aCO7TU12hf57d23xqKdheN95Z-ZB6BLDHQZc3QOQIqcEyhtObwVgwXJyhMaYM5FDRfExGv9aTtFZSh8AUJaMjtCoolTwkozR7L2L3nmtWh82WXCZylZ1p9Wq76KtrUp-s8qc0m2ImYuhydq1zaJqs_VuG9q1qlXTpXN04lSd7MWhTtDiabaYvuTzt-fX6eM815TzNi84MwSEcwXQghQC2NIZhkuDmQGohIYKFDeCcIy14SAKU2ElOK2YdZjQCbrex25j-OxsamXjk7Z1rTY2dElyKAgW_e__GTEtBSGs7I3F3qhjSClaJ7fRNyruJAY5UJYDQjkglJzKH8pyOOTqkN8tG2t-hw5Ye_1hr9sexpe3USbt7UZb46PVrTTB_73gG-3oiew</recordid><startdate>19830314</startdate><enddate>19830314</enddate><creator>Moltz, J.H.</creator><creator>Fawcett, C.P.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19830314</creationdate><title>Purification of a glucagon releasing factor from the rat hypothalamus</title><author>Moltz, J.H. ; Fawcett, C.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-487d209ff403424907bfd715d17d0069c060a8d92811cd8094d61a98367ef123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Chromatography, Gel</topic><topic>Chromatography, Ion Exchange</topic><topic>Glucagon - metabolism</topic><topic>glucagon releasing hormone</topic><topic>Hypothalamic Hormones - isolation & purification</topic><topic>Hypothalamic Hormones - pharmacology</topic><topic>hypothalamus</topic><topic>Hypothalamus - analysis</topic><topic>Islets of Langerhans - metabolism</topic><topic>Median Eminence - analysis</topic><topic>Peptides</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moltz, J.H.</creatorcontrib><creatorcontrib>Fawcett, C.P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moltz, J.H.</au><au>Fawcett, C.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Purification of a glucagon releasing factor from the rat hypothalamus</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1983-03-14</date><risdate>1983</risdate><volume>32</volume><issue>11</issue><spage>1271</spage><epage>1278</epage><pages>1271-1278</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The purification of a peptide from the rat hypothalamus which is capable of stimulating the release of glucagon from the endocrine pancreas and therefore named glucagon releasing factor (G1RF), is described. 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| fulltext | fulltext |
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| ispartof | Life sciences (1973), 1983-03, Vol.32 (11), p.1271-1278 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Chromatography, Gel Chromatography, Ion Exchange Glucagon - metabolism glucagon releasing hormone Hypothalamic Hormones - isolation & purification Hypothalamic Hormones - pharmacology hypothalamus Hypothalamus - analysis Islets of Langerhans - metabolism Median Eminence - analysis Peptides Rats |
| title | Purification of a glucagon releasing factor from the rat hypothalamus |
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