Temporal and Compositional Dietary Restrictions Modulate Age-Related Changes in Serum Lipids
Life-long restriction of food, which markedly increases the length of life of rats, also delays the occurrence of age-related physiological deteriorations including the age-related changes in serum lipids. The aim of this study was to explore the effects of 1) food restriction limited to early life,...
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| Veröffentlicht in: | The Journal of nutrition 1983-04, Vol.113 (4), p.880-892 |
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| creator | Masoro, Edward J. Compton, Charles Yu, Byung P. Bertrand, Helen |
| description | Life-long restriction of food, which markedly increases the length of life of rats, also delays the occurrence of age-related physiological deteriorations including the age-related changes in serum lipids. The aim of this study was to explore the effects of 1) food restriction limited to early life, 2) food restriction initiated in adult life and 3) restriction of protein without restriction of calories on the age-related changes in serum lipids. Food restriction started at 6 months of age was as effective as food restriction started at 6 weeks of age in modulating the age-related changes in serum lipids, whereas food restriction from 6 weeks to 6 months of age and restriction of protein but not calories were much less effective. Changes in the rate of very low density lipoprotein-triglyceride removal from the blood were not responsible for the age-related increase in triglyceride concentration or for the modulation of this increase by the dietary regimens. Age-related changes in serum or plasma levels of glucose, ketone bodies, insulin and glucagon were also measured and the modulating effects of the dietary regimens studied; possible relationships between the concentrations of these substances and the concentrations of the serum lipids are discussed. |
| doi_str_mv | 10.1093/jn/113.4.880 |
| format | Article |
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The aim of this study was to explore the effects of 1) food restriction limited to early life, 2) food restriction initiated in adult life and 3) restriction of protein without restriction of calories on the age-related changes in serum lipids. Food restriction started at 6 months of age was as effective as food restriction started at 6 weeks of age in modulating the age-related changes in serum lipids, whereas food restriction from 6 weeks to 6 months of age and restriction of protein but not calories were much less effective. Changes in the rate of very low density lipoprotein-triglyceride removal from the blood were not responsible for the age-related increase in triglyceride concentration or for the modulation of this increase by the dietary regimens. Age-related changes in serum or plasma levels of glucose, ketone bodies, insulin and glucagon were also measured and the modulating effects of the dietary regimens studied; possible relationships between the concentrations of these substances and the concentrations of the serum lipids are discussed.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/113.4.880</identifier><identifier>PMID: 6339693</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Aging ; Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Cholesterol - blood ; Diet ; Dietary Proteins - administration & dosage ; Energy Intake ; food restriction ; Fundamental and applied biological sciences. Psychology ; Glucagon - blood ; Insulin - blood ; Ketone Bodies - blood ; Lipids - blood ; Lipids. Glycolipids ; Lipoproteins, VLDL - blood ; Longevity ; Male ; Metabolisms and neurohumoral controls ; Rats ; Rats, Inbred F344 ; serum lipids ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 1983-04, Vol.113 (4), p.880-892</ispartof><rights>1983 American Society for Nutrition.</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-114a1ec7c494c2ff1436464bca704d7a052ab67ad6f23de11e55a54e3e4f95213</citedby><cites>FETCH-LOGICAL-c466t-114a1ec7c494c2ff1436464bca704d7a052ab67ad6f23de11e55a54e3e4f95213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9374564$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6339693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masoro, Edward J.</creatorcontrib><creatorcontrib>Compton, Charles</creatorcontrib><creatorcontrib>Yu, Byung P.</creatorcontrib><creatorcontrib>Bertrand, Helen</creatorcontrib><title>Temporal and Compositional Dietary Restrictions Modulate Age-Related Changes in Serum Lipids</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Life-long restriction of food, which markedly increases the length of life of rats, also delays the occurrence of age-related physiological deteriorations including the age-related changes in serum lipids. The aim of this study was to explore the effects of 1) food restriction limited to early life, 2) food restriction initiated in adult life and 3) restriction of protein without restriction of calories on the age-related changes in serum lipids. Food restriction started at 6 months of age was as effective as food restriction started at 6 weeks of age in modulating the age-related changes in serum lipids, whereas food restriction from 6 weeks to 6 months of age and restriction of protein but not calories were much less effective. Changes in the rate of very low density lipoprotein-triglyceride removal from the blood were not responsible for the age-related increase in triglyceride concentration or for the modulation of this increase by the dietary regimens. Age-related changes in serum or plasma levels of glucose, ketone bodies, insulin and glucagon were also measured and the modulating effects of the dietary regimens studied; possible relationships between the concentrations of these substances and the concentrations of the serum lipids are discussed.</description><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Cholesterol - blood</subject><subject>Diet</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Energy Intake</subject><subject>food restriction</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucagon - blood</subject><subject>Insulin - blood</subject><subject>Ketone Bodies - blood</subject><subject>Lipids - blood</subject><subject>Lipids. Glycolipids</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Longevity</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>serum lipids</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1r2zAUwMVY6dK0t10HPoyd5kTPepbjY0m3rpBS6MetIBTpuVOw5UyyC_3vK5PQ006S3vvpffwY-wp8AbwWy51fAogFLlYr_onNoETIJXD-mc04L4pcgJRf2FmMO845YL06ZadSiFrWYsaeH6nb90G3mfY2W_fpEd3gep8iV44GHd6ye4pDcGaKxuy2t2OrB8ouXyi_p-ma_v3V_oVi5nz2QGHsso3bOxvP2Umj20gXx3POnn7_elz_yTd31zfry01uUMohB0ANZCqDNZqiaQCFRIlboyuOttK8LPRWVtrKphCWAKgsdYkkCJu6LEDM2Y9D3X3o_41pWtW5aKhttad-jGrFseCixAT-PIAm9DEGatQ-uC7tqICrSabaeZVkKlRJZsK_HeuO247sB3y0l_Lfj3kdjW6boL1x8QOrRYWlnLrKA0bJwaujoKJx5A1ZF8gMyvbu__3fAQsRjtA</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>Masoro, Edward J.</creator><creator>Compton, Charles</creator><creator>Yu, Byung P.</creator><creator>Bertrand, Helen</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198304</creationdate><title>Temporal and Compositional Dietary Restrictions Modulate Age-Related Changes in Serum Lipids</title><author>Masoro, Edward J. ; Compton, Charles ; Yu, Byung P. ; Bertrand, Helen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-114a1ec7c494c2ff1436464bca704d7a052ab67ad6f23de11e55a54e3e4f95213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Cholesterol - blood</topic><topic>Diet</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Energy Intake</topic><topic>food restriction</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucagon - blood</topic><topic>Insulin - blood</topic><topic>Ketone Bodies - blood</topic><topic>Lipids - blood</topic><topic>Lipids. Glycolipids</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Longevity</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>serum lipids</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masoro, Edward J.</creatorcontrib><creatorcontrib>Compton, Charles</creatorcontrib><creatorcontrib>Yu, Byung P.</creatorcontrib><creatorcontrib>Bertrand, Helen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masoro, Edward J.</au><au>Compton, Charles</au><au>Yu, Byung P.</au><au>Bertrand, Helen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal and Compositional Dietary Restrictions Modulate Age-Related Changes in Serum Lipids</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1983-04</date><risdate>1983</risdate><volume>113</volume><issue>4</issue><spage>880</spage><epage>892</epage><pages>880-892</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Life-long restriction of food, which markedly increases the length of life of rats, also delays the occurrence of age-related physiological deteriorations including the age-related changes in serum lipids. The aim of this study was to explore the effects of 1) food restriction limited to early life, 2) food restriction initiated in adult life and 3) restriction of protein without restriction of calories on the age-related changes in serum lipids. Food restriction started at 6 months of age was as effective as food restriction started at 6 weeks of age in modulating the age-related changes in serum lipids, whereas food restriction from 6 weeks to 6 months of age and restriction of protein but not calories were much less effective. Changes in the rate of very low density lipoprotein-triglyceride removal from the blood were not responsible for the age-related increase in triglyceride concentration or for the modulation of this increase by the dietary regimens. Age-related changes in serum or plasma levels of glucose, ketone bodies, insulin and glucagon were also measured and the modulating effects of the dietary regimens studied; possible relationships between the concentrations of these substances and the concentrations of the serum lipids are discussed.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>6339693</pmid><doi>10.1093/jn/113.4.880</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1983-04, Vol.113 (4), p.880-892 |
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| subjects | Aging Animals Biological and medical sciences Blood Glucose - metabolism Cholesterol - blood Diet Dietary Proteins - administration & dosage Energy Intake food restriction Fundamental and applied biological sciences. Psychology Glucagon - blood Insulin - blood Ketone Bodies - blood Lipids - blood Lipids. Glycolipids Lipoproteins, VLDL - blood Longevity Male Metabolisms and neurohumoral controls Rats Rats, Inbred F344 serum lipids Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Temporal and Compositional Dietary Restrictions Modulate Age-Related Changes in Serum Lipids |
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