Plasma Levels of Prostaglandin Metabolites in Zinc-Deficient Female Rats Near Term
To investigate the possibility that impaired prostaglandin biosynthesis is involved in the development of postpartum illness in zinc-deficient female rats, plasma levels of three prostaglandin metabolites, 13,14-dihydro-15-keto PGF2α, 13,14-dihydro-15-keto PGE2, and 6-keto PGF1α were determined on d...
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| Veröffentlicht in: | The Journal of nutrition 1983-04, Vol.113 (4), p.760-765 |
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| container_title | The Journal of nutrition |
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| creator | O'Dell, B.L. Browning, J.D. Reeves, P.G. |
| description | To investigate the possibility that impaired prostaglandin biosynthesis is involved in the development of postpartum illness in zinc-deficient female rats, plasma levels of three prostaglandin metabolites, 13,14-dihydro-15-keto PGF2α, 13,14-dihydro-15-keto PGE2, and 6-keto PGF1α were determined on day 22 of gestation. During the gestation period female rats were fed low zinc ( |
| doi_str_mv | 10.1093/jn/113.4.760 |
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During the gestation period female rats were fed low zinc (<1 ppm) diets based on soybean protein or similar control diets (100 ppm Zn). Two levels of vitamin E, 15 and 65 IU per kilogram, were added to the diet. Zinc deficiency in dams fed the diet containing 65 IU/kg vitamin E resulted in significantly higher plasma levels of 13,14-dihydro-15-keto PGF2α than controls; plasma 6-keto PGF1α levels were not different. Zinc-deficient dams fed the basal diet containing 15 IU/kg vitamin E had significantly higher plasma levels of all three prostaglandin metabolites than controls. The pathology of zinc deficiency is not due to decreased prostaglandin production, but the present results and the pathological signs are consistent with failure of prostaglandin function.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/113.4.760</identifier><identifier>PMID: 6687606</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>6-Ketoprostaglandin F1 alpha - blood ; Animals ; Biological and medical sciences ; Dinoprost - analogs & derivatives ; Dinoprostone - analogs & derivatives ; Dose-Response Relationship, Drug ; Female ; female rat ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Pregnancy ; Pregnancy Complications - metabolism ; Pregnancy. Parturition. Lactation ; prostaglandin metabolites ; prostaglandins ; Prostaglandins - biosynthesis ; Prostaglandins - blood ; Prostaglandins E - blood ; Prostaglandins F - blood ; Rats ; Rats, Inbred Strains ; Reproduction - drug effects ; Vertebrates: reproduction ; Vitamin E - administration & dosage ; Zinc - blood ; Zinc - deficiency</subject><ispartof>The Journal of nutrition, 1983-04, Vol.113 (4), p.760-765</ispartof><rights>1983 American Society for Nutrition.</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-187abad9cac77ed64af5a3369f1e55fc61928300a373144f4a49cf1a161eafc3</citedby><cites>FETCH-LOGICAL-c400t-187abad9cac77ed64af5a3369f1e55fc61928300a373144f4a49cf1a161eafc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9452127$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6687606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Dell, B.L.</creatorcontrib><creatorcontrib>Browning, J.D.</creatorcontrib><creatorcontrib>Reeves, P.G.</creatorcontrib><title>Plasma Levels of Prostaglandin Metabolites in Zinc-Deficient Female Rats Near Term</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>To investigate the possibility that impaired prostaglandin biosynthesis is involved in the development of postpartum illness in zinc-deficient female rats, plasma levels of three prostaglandin metabolites, 13,14-dihydro-15-keto PGF2α, 13,14-dihydro-15-keto PGE2, and 6-keto PGF1α were determined on day 22 of gestation. During the gestation period female rats were fed low zinc (<1 ppm) diets based on soybean protein or similar control diets (100 ppm Zn). Two levels of vitamin E, 15 and 65 IU per kilogram, were added to the diet. Zinc deficiency in dams fed the diet containing 65 IU/kg vitamin E resulted in significantly higher plasma levels of 13,14-dihydro-15-keto PGF2α than controls; plasma 6-keto PGF1α levels were not different. Zinc-deficient dams fed the basal diet containing 15 IU/kg vitamin E had significantly higher plasma levels of all three prostaglandin metabolites than controls. The pathology of zinc deficiency is not due to decreased prostaglandin production, but the present results and the pathological signs are consistent with failure of prostaglandin function.</description><subject>6-Ketoprostaglandin F1 alpha - blood</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Dinoprostone - analogs & derivatives</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>female rat</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - metabolism</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>prostaglandin metabolites</subject><subject>prostaglandins</subject><subject>Prostaglandins - biosynthesis</subject><subject>Prostaglandins - blood</subject><subject>Prostaglandins E - blood</subject><subject>Prostaglandins F - blood</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reproduction - drug effects</subject><subject>Vertebrates: reproduction</subject><subject>Vitamin E - administration & dosage</subject><subject>Zinc - blood</subject><subject>Zinc - deficiency</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1rGzEQhkVocN0kt14LOpSeuo5mpdWujiVp0oKTBuNTLmKsHRWZ_UildSD_vjI2PuU0DPPwzszD2GcQCxBGXm-HawC5UItaizM2h0pBoUGID2wuRFkWErT-yD6ltBVCgDLNjM20bjKt52z11GHqkS_plbrER8-f4pgm_Nvh0IaBP9CEm7ELEyWe2-cwuOKWfHCBhonfUY8d8RVOiT8SRr6m2F-yc49doqtjvWDru5_rm1_F8s_975sfy8IpIaYCmho32BqHrq6p1Qp9hVJq44GqyjsNpmykEChrCUp5hco4DwgaCL2TF-zbIfYljv92lCbbh-Soy4fTuEu2EQqMMlUGvx9Alz9Lkbx9iaHH-GZB2L1Bux1sNmiVzU4y_uWYu9v01J7go7I8_3qcY3LY-YiDC-mEGVWVUNYZ0wcsa6XXQNGmvTNHbYjkJtuO4f39_wGdbIqY</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>O'Dell, B.L.</creator><creator>Browning, J.D.</creator><creator>Reeves, P.G.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198304</creationdate><title>Plasma Levels of Prostaglandin Metabolites in Zinc-Deficient Female Rats Near Term</title><author>O'Dell, B.L. ; Browning, J.D. ; Reeves, P.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-187abad9cac77ed64af5a3369f1e55fc61928300a373144f4a49cf1a161eafc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>6-Ketoprostaglandin F1 alpha - blood</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dinoprost - analogs & derivatives</topic><topic>Dinoprostone - analogs & derivatives</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>female rat</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - metabolism</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>prostaglandin metabolites</topic><topic>prostaglandins</topic><topic>Prostaglandins - biosynthesis</topic><topic>Prostaglandins - blood</topic><topic>Prostaglandins E - blood</topic><topic>Prostaglandins F - blood</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reproduction - drug effects</topic><topic>Vertebrates: reproduction</topic><topic>Vitamin E - administration & dosage</topic><topic>Zinc - blood</topic><topic>Zinc - deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Dell, B.L.</creatorcontrib><creatorcontrib>Browning, J.D.</creatorcontrib><creatorcontrib>Reeves, P.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Dell, B.L.</au><au>Browning, J.D.</au><au>Reeves, P.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Levels of Prostaglandin Metabolites in Zinc-Deficient Female Rats Near Term</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1983-04</date><risdate>1983</risdate><volume>113</volume><issue>4</issue><spage>760</spage><epage>765</epage><pages>760-765</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>To investigate the possibility that impaired prostaglandin biosynthesis is involved in the development of postpartum illness in zinc-deficient female rats, plasma levels of three prostaglandin metabolites, 13,14-dihydro-15-keto PGF2α, 13,14-dihydro-15-keto PGE2, and 6-keto PGF1α were determined on day 22 of gestation. During the gestation period female rats were fed low zinc (<1 ppm) diets based on soybean protein or similar control diets (100 ppm Zn). Two levels of vitamin E, 15 and 65 IU per kilogram, were added to the diet. Zinc deficiency in dams fed the diet containing 65 IU/kg vitamin E resulted in significantly higher plasma levels of 13,14-dihydro-15-keto PGF2α than controls; plasma 6-keto PGF1α levels were not different. Zinc-deficient dams fed the basal diet containing 15 IU/kg vitamin E had significantly higher plasma levels of all three prostaglandin metabolites than controls. The pathology of zinc deficiency is not due to decreased prostaglandin production, but the present results and the pathological signs are consistent with failure of prostaglandin function.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>6687606</pmid><doi>10.1093/jn/113.4.760</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1983-04, Vol.113 (4), p.760-765 |
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| subjects | 6-Ketoprostaglandin F1 alpha - blood Animals Biological and medical sciences Dinoprost - analogs & derivatives Dinoprostone - analogs & derivatives Dose-Response Relationship, Drug Female female rat Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Pregnancy Pregnancy Complications - metabolism Pregnancy. Parturition. Lactation prostaglandin metabolites prostaglandins Prostaglandins - biosynthesis Prostaglandins - blood Prostaglandins E - blood Prostaglandins F - blood Rats Rats, Inbred Strains Reproduction - drug effects Vertebrates: reproduction Vitamin E - administration & dosage Zinc - blood Zinc - deficiency |
| title | Plasma Levels of Prostaglandin Metabolites in Zinc-Deficient Female Rats Near Term |
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