Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium
A well recognized feature of the immune response to parasitic helminth infections, including schistosomiasis, is the production of large amounts of specific and nonspecific IgE1,2. Immunological pathways involving IgE can lead to damage to the developing schistosomulum and it has been suggested that...
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| Veröffentlicht in: | Nature (London) 1991-01, Vol.349 (6306), p.243-245 |
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| creator | HAGAN, P BLUMENTHAL, U. J DUNN, D SIMPSON, A. J. G WILKINS, H. A |
| description | A well recognized feature of the immune response to parasitic helminth infections, including schistosomiasis, is the production of large amounts of specific and nonspecific IgE1,2. Immunological pathways involving IgE can lead to damage to the developing schistosomulum and it has been suggested that responses involving IgE could have evolved as protection against helminth infections. There has been no epidemiological evidence to support this idea and the only significant IgE responses known in man are those involved in the pathogenesis of allergic disease. Here we measure serological response during reinfection with S. haematobium and demonstrate that IgE antibodies in man can be beneficial. Our results support the hypothesis that the slow build-up of IgE to high levels and the early production of IgG4 antibodies, which may block IgE pathways are responsible for delaying the development of protective immunity to S. haematobium. |
| doi_str_mv | 10.1038/349243a0 |
| format | Article |
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J ; DUNN, D ; SIMPSON, A. J. G ; WILKINS, H. A</creator><creatorcontrib>HAGAN, P ; BLUMENTHAL, U. J ; DUNN, D ; SIMPSON, A. J. G ; WILKINS, H. A</creatorcontrib><description>A well recognized feature of the immune response to parasitic helminth infections, including schistosomiasis, is the production of large amounts of specific and nonspecific IgE1,2. Immunological pathways involving IgE can lead to damage to the developing schistosomulum and it has been suggested that responses involving IgE could have evolved as protection against helminth infections. There has been no epidemiological evidence to support this idea and the only significant IgE responses known in man are those involved in the pathogenesis of allergic disease. Here we measure serological response during reinfection with S. haematobium and demonstrate that IgE antibodies in man can be beneficial. Our results support the hypothesis that the slow build-up of IgE to high levels and the early production of IgG4 antibodies, which may block IgE pathways are responsible for delaying the development of protective immunity to S. haematobium.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/349243a0</identifier><identifier>PMID: 1898985</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Adolescent ; Aging - immunology ; Animals ; Antibodies, Helminth - blood ; Biological and medical sciences ; Child ; Diseases caused by trematodes ; Helminthic diseases ; Humans ; Immune response ; Immunity (Disease) ; Immunity, Innate - immunology ; Immunoglobulin E - physiology ; Immunoglobulin G - physiology ; Infections ; Infectious diseases ; Medical research ; Medical sciences ; Parasites ; Parasitic diseases ; Recurrence ; Regression Analysis ; Schistosomiases ; Schistosomiasis ; Schistosomiasis haematobia - immunology ; Tropical medicine</subject><ispartof>Nature (London), 1991-01, Vol.349 (6306), p.243-245</ispartof><rights>1991 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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There has been no epidemiological evidence to support this idea and the only significant IgE responses known in man are those involved in the pathogenesis of allergic disease. Here we measure serological response during reinfection with S. haematobium and demonstrate that IgE antibodies in man can be beneficial. Our results support the hypothesis that the slow build-up of IgE to high levels and the early production of IgG4 antibodies, which may block IgE pathways are responsible for delaying the development of protective immunity to S. haematobium.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>1898985</pmid><doi>10.1038/349243a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1991-01, Vol.349 (6306), p.243-245 |
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| subjects | Adolescent Aging - immunology Animals Antibodies, Helminth - blood Biological and medical sciences Child Diseases caused by trematodes Helminthic diseases Humans Immune response Immunity (Disease) Immunity, Innate - immunology Immunoglobulin E - physiology Immunoglobulin G - physiology Infections Infectious diseases Medical research Medical sciences Parasites Parasitic diseases Recurrence Regression Analysis Schistosomiases Schistosomiasis Schistosomiasis haematobia - immunology Tropical medicine |
| title | Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium |
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