STUDIES ON TOMAYMYCIN. II: TOTAL SYNTHESES OF THE ANTITUMOR ANTIBIOTICS, E- AND Z-TOMAYMYCINS

STUDIES ON TOMAYMYCIN. II: TOTAL SYNTHESES OF THE ANTITUMOR ANTIBIOTICS, E- AND Z-TOMAYMYCINS

The total syntheses of naturally occurring E-tomaymycin (1E) and its olefinic geometrical isomer, Z-tomaymycin (1Z) are described. The Z-isomer was found to have the same antibacterial activity as E-isomer (1E).

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Veröffentlicht in:Journal of antibiotics 1983, Vol.36(3), pp.276-282
Hauptverfasser: TOZUKA, ZENZABURO, TAKASUGI, HISASHI, TAKAYA, TAKAO
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics, Antineoplastic - chemical synthesis
Benzodiazepinones - chemical synthesis
Benzodiazepinones - pharmacology
Chemical Phenomena
Chemistry
Microbial Sensitivity Tests
Stereoisomerism
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container_end_page 282
container_issue 3
container_start_page 276
container_title Journal of antibiotics
container_volume 36
creator TOZUKA, ZENZABURO
TAKASUGI, HISASHI
TAKAYA, TAKAO
description The total syntheses of naturally occurring E-tomaymycin (1E) and its olefinic geometrical isomer, Z-tomaymycin (1Z) are described. The Z-isomer was found to have the same antibacterial activity as E-isomer (1E).
doi_str_mv 10.7164/antibiotics.36.276
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subjects Antibiotics, Antineoplastic - chemical synthesis
Benzodiazepinones - chemical synthesis
Benzodiazepinones - pharmacology
Chemical Phenomena
Chemistry
Microbial Sensitivity Tests
Stereoisomerism
title STUDIES ON TOMAYMYCIN. II: TOTAL SYNTHESES OF THE ANTITUMOR ANTIBIOTICS, E- AND Z-TOMAYMYCINS
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