Beta blockade in asymptomatic diabetics with abnormal rest electrocardiograms
Diabetic patients without evidence of vascular disease often reveal non-specific ST-T changes and prolonged QTc intervals in their ECGs. In an attempt to elucidate the role of autonomic dysfunction in the etiology of these changes we compared the ECGs and beat to beat variations in 22 patients with...
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| Veröffentlicht in: | Journal of electrocardiology 1983, Vol.16 (1), p.87-90 |
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| container_title | Journal of electrocardiology |
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| creator | Merdler, Amnon Abinader, Edward G. Flugelman, Moshe Y. Kanter, Yoram |
| description | Diabetic patients without evidence of vascular disease often reveal non-specific ST-T changes and prolonged QTc intervals in their ECGs. In an attempt to elucidate the role of autonomic dysfunction in the etiology of these changes we compared the ECGs and beat to beat variations in 22 patients with changes in repolarization before and one hour after beta blockade. None had clinical evidence of ischaemic heart diease or peripheral vascular disease. In 19 patients (86%) the ST-T changes persisted after beta blockade. Heart rate was 75.6±15.3/min before and 64.3±9.6/min after beta blockade, while the QTc interval was 0.43±0.02 sec before and 0.41±0.02 sec after propranolol. Beat to beat variation during deep breathing is diminished in diabetic patients. Beta blockade reversed this phenomena.
We conclude that while beat to beat variations and prolongation of QTc are likely to be consequent to autonomic neuropathy, the ST-T changes do not appear to be due to increased sympathetic tone and their etiology is yet to be determined. |
| doi_str_mv | 10.1016/S0022-0736(83)80163-0 |
| format | Article |
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We conclude that while beat to beat variations and prolongation of QTc are likely to be consequent to autonomic neuropathy, the ST-T changes do not appear to be due to increased sympathetic tone and their etiology is yet to be determined.</description><identifier>ISSN: 0022-0736</identifier><identifier>EISSN: 1532-8430</identifier><identifier>DOI: 10.1016/S0022-0736(83)80163-0</identifier><identifier>PMID: 6833926</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Autonomic Nervous System Diseases - physiopathology ; Diabetes Mellitus - physiopathology ; Diabetic Neuropathies - physiopathology ; Electrocardiography ; Female ; Heart Rate - drug effects ; Humans ; Male ; Middle Aged ; Propranolol - pharmacology ; Rest</subject><ispartof>Journal of electrocardiology, 1983, Vol.16 (1), p.87-90</ispartof><rights>1983 Research in Electrocardiology, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-bc1764a0349eb271313f02562f8b4132e9f64ac934b04307eccd1e17dda5320e3</citedby><cites>FETCH-LOGICAL-c360t-bc1764a0349eb271313f02562f8b4132e9f64ac934b04307eccd1e17dda5320e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-0736(83)80163-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6833926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merdler, Amnon</creatorcontrib><creatorcontrib>Abinader, Edward G.</creatorcontrib><creatorcontrib>Flugelman, Moshe Y.</creatorcontrib><creatorcontrib>Kanter, Yoram</creatorcontrib><title>Beta blockade in asymptomatic diabetics with abnormal rest electrocardiograms</title><title>Journal of electrocardiology</title><addtitle>J Electrocardiol</addtitle><description>Diabetic patients without evidence of vascular disease often reveal non-specific ST-T changes and prolonged QTc intervals in their ECGs. In an attempt to elucidate the role of autonomic dysfunction in the etiology of these changes we compared the ECGs and beat to beat variations in 22 patients with changes in repolarization before and one hour after beta blockade. None had clinical evidence of ischaemic heart diease or peripheral vascular disease. In 19 patients (86%) the ST-T changes persisted after beta blockade. Heart rate was 75.6±15.3/min before and 64.3±9.6/min after beta blockade, while the QTc interval was 0.43±0.02 sec before and 0.41±0.02 sec after propranolol. Beat to beat variation during deep breathing is diminished in diabetic patients. Beta blockade reversed this phenomena.
We conclude that while beat to beat variations and prolongation of QTc are likely to be consequent to autonomic neuropathy, the ST-T changes do not appear to be due to increased sympathetic tone and their etiology is yet to be determined.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetic Neuropathies - physiopathology</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Propranolol - pharmacology</subject><subject>Rest</subject><issn>0022-0736</issn><issn>1532-8430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EKqXwCZW8QrAIjO00jxWCipdUxAJYW449AUMSFzsF9e9xH-qW1Vhz78z4HkLGDC4YsOzyBYDzBHKRnRXivIgtkcAeGbKJ4EmRCtgnw53lkByF8AkAJc_5gAyyQoiSZ0PydIO9olXj9JcySG1HVVi28961qreaGqsqjI9Af23_QVXVOd-qhnoMPcUGde-dVt5Y9-5VG47JQa2agCfbOiJvd7ev04dk9nz_OL2eJVpk0CeVZnmWKhBpiRXPmWCiBj7JeF1UKRMcyzrKuhRpBTFIjlobhiw3RsVwgGJETjd75959L-JfZGuDxqZRHbpFkAWs1pRpNE42Ru1dCB5rOfe2VX4pGcgVRrnGKFeMZCHkGqOEODfeHlhULZrd1JZb1K82OsaUPxa9DNpip9FYH6FI4-w_F_4ADNWB4g</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Merdler, Amnon</creator><creator>Abinader, Edward G.</creator><creator>Flugelman, Moshe Y.</creator><creator>Kanter, Yoram</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Beta blockade in asymptomatic diabetics with abnormal rest electrocardiograms</title><author>Merdler, Amnon ; Abinader, Edward G. ; Flugelman, Moshe Y. ; Kanter, Yoram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-bc1764a0349eb271313f02562f8b4132e9f64ac934b04307eccd1e17dda5320e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetic Neuropathies - physiopathology</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Propranolol - pharmacology</topic><topic>Rest</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merdler, Amnon</creatorcontrib><creatorcontrib>Abinader, Edward G.</creatorcontrib><creatorcontrib>Flugelman, Moshe Y.</creatorcontrib><creatorcontrib>Kanter, Yoram</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of electrocardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merdler, Amnon</au><au>Abinader, Edward G.</au><au>Flugelman, Moshe Y.</au><au>Kanter, Yoram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta blockade in asymptomatic diabetics with abnormal rest electrocardiograms</atitle><jtitle>Journal of electrocardiology</jtitle><addtitle>J Electrocardiol</addtitle><date>1983</date><risdate>1983</risdate><volume>16</volume><issue>1</issue><spage>87</spage><epage>90</epage><pages>87-90</pages><issn>0022-0736</issn><eissn>1532-8430</eissn><abstract>Diabetic patients without evidence of vascular disease often reveal non-specific ST-T changes and prolonged QTc intervals in their ECGs. In an attempt to elucidate the role of autonomic dysfunction in the etiology of these changes we compared the ECGs and beat to beat variations in 22 patients with changes in repolarization before and one hour after beta blockade. None had clinical evidence of ischaemic heart diease or peripheral vascular disease. In 19 patients (86%) the ST-T changes persisted after beta blockade. Heart rate was 75.6±15.3/min before and 64.3±9.6/min after beta blockade, while the QTc interval was 0.43±0.02 sec before and 0.41±0.02 sec after propranolol. Beat to beat variation during deep breathing is diminished in diabetic patients. Beta blockade reversed this phenomena.
We conclude that while beat to beat variations and prolongation of QTc are likely to be consequent to autonomic neuropathy, the ST-T changes do not appear to be due to increased sympathetic tone and their etiology is yet to be determined.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6833926</pmid><doi>10.1016/S0022-0736(83)80163-0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of electrocardiology, 1983, Vol.16 (1), p.87-90 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Autonomic Nervous System Diseases - physiopathology Diabetes Mellitus - physiopathology Diabetic Neuropathies - physiopathology Electrocardiography Female Heart Rate - drug effects Humans Male Middle Aged Propranolol - pharmacology Rest |
| title | Beta blockade in asymptomatic diabetics with abnormal rest electrocardiograms |
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