Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes
The authors have now analyzed several aspects of immune responsiveness in SLE strains, compared with age- and allotypematched normal controls, to thymus-independent class 1 and 2 (Tl-1,2) antigens as well as to thymus-dependent (TD) antigens. Results indicate that all SLE strains are hyperresponsive...
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| Veröffentlicht in: | The Journal of immunology (1950) 1983-05, Vol.130 (5), p.2161-2167 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 130 |
| creator | Park, C L Balderas, R S Fieser, T M Slack, J H Prud'Homme, G J Dixon, F J Theofilopoulos, A N |
| description | The authors have now analyzed several aspects of immune responsiveness in SLE strains, compared with age- and allotypematched normal controls, to thymus-independent class 1 and 2 (Tl-1,2) antigens as well as to thymus-dependent (TD) antigens. Results indicate that all SLE strains are hyperresponsive to both TD and TI antigens and that their immunoglobulin (Ig) isotypic and IgG subclass profiles are different from those in normal strains; in general, an expansion of IgG2 subclass antibodies was observed. Moreover, NZ mice acquired immune competence with respect to Ti-2 antigen earlier than the other strains tested. Some, but not all, SLE strains sustained IgG immune responses to TI-2 antigens for longer periods than normal strains, whereas the avidities of antibodies produced in all SLE strains resembled those of their normal counterparts. |
| doi_str_mv | 10.4049/jimmunol.130.5.2161 |
| format | Article |
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Results indicate that all SLE strains are hyperresponsive to both TD and TI antigens and that their immunoglobulin (Ig) isotypic and IgG subclass profiles are different from those in normal strains; in general, an expansion of IgG2 subclass antibodies was observed. Moreover, NZ mice acquired immune competence with respect to Ti-2 antigen earlier than the other strains tested. Some, but not all, SLE strains sustained IgG immune responses to TI-2 antigens for longer periods than normal strains, whereas the avidities of antibodies produced in all SLE strains resembled those of their normal counterparts.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.130.5.2161</identifier><identifier>PMID: 6339623</identifier><language>eng</language><publisher>United States</publisher><subject>Aging ; Animals ; Antibody Affinity ; Antibody-Producing Cells - immunology ; Antigens, T-Independent - immunology ; Female ; Ficoll - analogs & derivatives ; Ficoll - immunology ; Hemocyanins - immunology ; Hemolytic Plaque Technique ; Immunoglobulin Allotypes - analysis ; Immunoglobulin Allotypes - biosynthesis ; Immunoglobulin Allotypes - immunology ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - classification ; Immunoglobulin G - immunology ; Kinetics ; Lipopolysaccharides - immunology ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - mortality ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred NZB ; Rabbits ; Syndrome ; Trinitrobenzenes - immunology</subject><ispartof>The Journal of immunology (1950), 1983-05, Vol.130 (5), p.2161-2167</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2911-684b1fa87f1497e4937060ef42ec135c0008b02029847a8e91758b7d42e6d07b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6339623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, C L</creatorcontrib><creatorcontrib>Balderas, R S</creatorcontrib><creatorcontrib>Fieser, T M</creatorcontrib><creatorcontrib>Slack, J H</creatorcontrib><creatorcontrib>Prud'Homme, G J</creatorcontrib><creatorcontrib>Dixon, F J</creatorcontrib><creatorcontrib>Theofilopoulos, A N</creatorcontrib><title>Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The authors have now analyzed several aspects of immune responsiveness in SLE strains, compared with age- and allotypematched normal controls, to thymus-independent class 1 and 2 (Tl-1,2) antigens as well as to thymus-dependent (TD) antigens. Results indicate that all SLE strains are hyperresponsive to both TD and TI antigens and that their immunoglobulin (Ig) isotypic and IgG subclass profiles are different from those in normal strains; in general, an expansion of IgG2 subclass antibodies was observed. Moreover, NZ mice acquired immune competence with respect to Ti-2 antigen earlier than the other strains tested. Some, but not all, SLE strains sustained IgG immune responses to TI-2 antigens for longer periods than normal strains, whereas the avidities of antibodies produced in all SLE strains resembled those of their normal counterparts.</description><subject>Aging</subject><subject>Animals</subject><subject>Antibody Affinity</subject><subject>Antibody-Producing Cells - immunology</subject><subject>Antigens, T-Independent - immunology</subject><subject>Female</subject><subject>Ficoll - analogs & derivatives</subject><subject>Ficoll - immunology</subject><subject>Hemocyanins - immunology</subject><subject>Hemolytic Plaque Technique</subject><subject>Immunoglobulin Allotypes - analysis</subject><subject>Immunoglobulin Allotypes - biosynthesis</subject><subject>Immunoglobulin Allotypes - immunology</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulin G - immunology</subject><subject>Kinetics</subject><subject>Lipopolysaccharides - immunology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Erythematosus, Systemic - mortality</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred NZB</subject><subject>Rabbits</subject><subject>Syndrome</subject><subject>Trinitrobenzenes - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQha0K1F5Kn6Cq5BW7XPwXO16iiv5IldjAOkqcCddVYqceR5BH4W1x2wtix8oa-3zHOnMIueRsr5iyHx_9PK8hTnsu2b7eC675CdnxumaV1ky_ITvGhKi40eaMvEN8ZIxpJtQpOdVSWi3kjvy6x5i3xTu6pDj6CZB2YaAxHyDR0Qeg7tClzmVIHrN3SONIX_4FmgCXGLAgOVL4Gb9DiGsZDtu8YjXAAmGAkF8MKx_-vci-iJH2G529A_rD5wOd1qXQuIUhxRnwPXk7dhPCxfE8J99uPn-9vqsevtzeX396qJywnFe6UT0fu8aMXFkDykpTQsKoBDgua1cyNz0TTNhGma4By03d9GYo73pgppfn5MOrb1nA0wqY29mjg2nqApQ4bcMUF8aq_wq5NEJza4tQvgpdiogJxnZJfu7S1nLWPjfX_mmuMKyt2-fmCnV1tF_7GYa_zLEq-Rvv2ZoJ</recordid><startdate>198305</startdate><enddate>198305</enddate><creator>Park, C L</creator><creator>Balderas, R S</creator><creator>Fieser, T M</creator><creator>Slack, J H</creator><creator>Prud'Homme, G J</creator><creator>Dixon, F J</creator><creator>Theofilopoulos, A N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198305</creationdate><title>Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes</title><author>Park, C L ; Balderas, R S ; Fieser, T M ; Slack, J H ; Prud'Homme, G J ; Dixon, F J ; Theofilopoulos, A N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2911-684b1fa87f1497e4937060ef42ec135c0008b02029847a8e91758b7d42e6d07b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Antibody Affinity</topic><topic>Antibody-Producing Cells - immunology</topic><topic>Antigens, T-Independent - immunology</topic><topic>Female</topic><topic>Ficoll - analogs & derivatives</topic><topic>Ficoll - immunology</topic><topic>Hemocyanins - immunology</topic><topic>Hemolytic Plaque Technique</topic><topic>Immunoglobulin Allotypes - analysis</topic><topic>Immunoglobulin Allotypes - biosynthesis</topic><topic>Immunoglobulin Allotypes - immunology</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulin G - immunology</topic><topic>Kinetics</topic><topic>Lipopolysaccharides - immunology</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Erythematosus, Systemic - mortality</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred NZB</topic><topic>Rabbits</topic><topic>Syndrome</topic><topic>Trinitrobenzenes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, C L</creatorcontrib><creatorcontrib>Balderas, R S</creatorcontrib><creatorcontrib>Fieser, T M</creatorcontrib><creatorcontrib>Slack, J H</creatorcontrib><creatorcontrib>Prud'Homme, G J</creatorcontrib><creatorcontrib>Dixon, F J</creatorcontrib><creatorcontrib>Theofilopoulos, A N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, C L</au><au>Balderas, R S</au><au>Fieser, T M</au><au>Slack, J H</au><au>Prud'Homme, G J</au><au>Dixon, F J</au><au>Theofilopoulos, A N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1983-05</date><risdate>1983</risdate><volume>130</volume><issue>5</issue><spage>2161</spage><epage>2167</epage><pages>2161-2167</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>The authors have now analyzed several aspects of immune responsiveness in SLE strains, compared with age- and allotypematched normal controls, to thymus-independent class 1 and 2 (Tl-1,2) antigens as well as to thymus-dependent (TD) antigens. Results indicate that all SLE strains are hyperresponsive to both TD and TI antigens and that their immunoglobulin (Ig) isotypic and IgG subclass profiles are different from those in normal strains; in general, an expansion of IgG2 subclass antibodies was observed. Moreover, NZ mice acquired immune competence with respect to Ti-2 antigen earlier than the other strains tested. Some, but not all, SLE strains sustained IgG immune responses to TI-2 antigens for longer periods than normal strains, whereas the avidities of antibodies produced in all SLE strains resembled those of their normal counterparts.</abstract><cop>United States</cop><pmid>6339623</pmid><doi>10.4049/jimmunol.130.5.2161</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aging Animals Antibody Affinity Antibody-Producing Cells - immunology Antigens, T-Independent - immunology Female Ficoll - analogs & derivatives Ficoll - immunology Hemocyanins - immunology Hemolytic Plaque Technique Immunoglobulin Allotypes - analysis Immunoglobulin Allotypes - biosynthesis Immunoglobulin Allotypes - immunology Immunoglobulin G - biosynthesis Immunoglobulin G - classification Immunoglobulin G - immunology Kinetics Lipopolysaccharides - immunology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - mortality Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NZB Rabbits Syndrome Trinitrobenzenes - immunology |
| title | Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes |
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