Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis
Leukotrienes, hydroperoxyeicosatetraenoic acids (HPETE), and hydroxyeicostetraenoic acids (HETE) are products of arachidonic acid metabolism via the lipoxygenase pathway. They have been shown to be highly potent and stereospecific factors stimulating polymorphonuclear leukocyte (PMNL) migration and...
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| Veröffentlicht in: | Biochemical pharmacology 1983, Vol.32 (1), p.170-172 |
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| container_title | Biochemical pharmacology |
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| creator | Sircar, Jagadish C. Schwender, Charles F. Carethers, Mary E. |
| description | Leukotrienes, hydroperoxyeicosatetraenoic acids (HPETE), and hydroxyeicostetraenoic acids (HETE) are products of arachidonic acid metabolism via the lipoxygenase pathway. They have been shown to be highly potent and stereospecific factors stimulating polymorphonuclear leukocyte (PMNL) migration and enhancing vascular permeability (15). Since sulfasalazine and 5-ASA inhibit the migration of PMNL, it seems possible that sulfasalazine and 5-aminosalicyclic acid (5-ASA) might be working in part through inhibition of the lipoxygenase pathway. To test the above hypothesis, the authors evaluated sulfasalazine and 5-ASA for possible lipoxygenase inhibitor activity. |
| doi_str_mv | 10.1016/0006-2952(83)90673-1 |
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They have been shown to be highly potent and stereospecific factors stimulating polymorphonuclear leukocyte (PMNL) migration and enhancing vascular permeability (15). Since sulfasalazine and 5-ASA inhibit the migration of PMNL, it seems possible that sulfasalazine and 5-aminosalicyclic acid (5-ASA) might be working in part through inhibition of the lipoxygenase pathway. To test the above hypothesis, the authors evaluated sulfasalazine and 5-ASA for possible lipoxygenase inhibitor activity.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(83)90673-1</identifier><identifier>PMID: 6131674</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>5-aminosalicyclic acid ; Aminosalicylic Acids - pharmacology ; Colitis, Ulcerative - drug therapy ; Glycine max ; Glycine max - enzymology ; Humans ; Kinetics ; lipoxygenase ; Lipoxygenase Inhibitors ; Mesalamine ; sulfasalazine ; Sulfasalazine - pharmacology</subject><ispartof>Biochemical pharmacology, 1983, Vol.32 (1), p.170-172</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-baf96a6ec9538d4b709049b764ef92ce526df2ef1c1c47941c34575c00c5efe93</citedby><cites>FETCH-LOGICAL-c388t-baf96a6ec9538d4b709049b764ef92ce526df2ef1c1c47941c34575c00c5efe93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(83)90673-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6131674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sircar, Jagadish C.</creatorcontrib><creatorcontrib>Schwender, Charles F.</creatorcontrib><creatorcontrib>Carethers, Mary E.</creatorcontrib><title>Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>Leukotrienes, hydroperoxyeicosatetraenoic acids (HPETE), and hydroxyeicostetraenoic acids (HETE) are products of arachidonic acid metabolism via the lipoxygenase pathway. They have been shown to be highly potent and stereospecific factors stimulating polymorphonuclear leukocyte (PMNL) migration and enhancing vascular permeability (15). Since sulfasalazine and 5-ASA inhibit the migration of PMNL, it seems possible that sulfasalazine and 5-aminosalicyclic acid (5-ASA) might be working in part through inhibition of the lipoxygenase pathway. To test the above hypothesis, the authors evaluated sulfasalazine and 5-ASA for possible lipoxygenase inhibitor activity.</description><subject>5-aminosalicyclic acid</subject><subject>Aminosalicylic Acids - pharmacology</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Glycine max</subject><subject>Glycine max - enzymology</subject><subject>Humans</subject><subject>Kinetics</subject><subject>lipoxygenase</subject><subject>Lipoxygenase Inhibitors</subject><subject>Mesalamine</subject><subject>sulfasalazine</subject><subject>Sulfasalazine - pharmacology</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAUtBBVWRb-AUg-ITik2PFHbA5IqOKjUqVe4Gw5zjMYOfYSJxXpgd-O0131CAfLfn4z8_RmEHpByQUlVL4lhMim1aJ9rdgbTWTHGvoI7aiqj1ZL9RjtHiBP0NNSfm6lkvQcnUvKqOz4Dv25Sj9CH-aQE84el7z2YBOO4ZB_r98h2QK4X3FZorfFRnsXEmCbBiwaO4aU619waz3YujC8wxYfcimhj4DHPMCmad29ekh4iQ4mO4dbwC7HOrQ8Q2fexgLPT_ceffv08evll-b65vPV5YfrxjGl5qa3XksrwWnB1MD7jmjCdd9JDl63DkQrB9-Cp4463mlOHeOiE44QJ8CDZnv06qh7mPKvBcpsxlAcxGgT5KUYRTjptBT_BVImScsFr0B-BLqpLjyBN4cpjHZaDSVmy8dsbpvNfKOYuc-nsvfo5Ul_6UcYHkinQGr__bEP1Y3bAJMpLkByMIQJ3GyGHP494C-QfKD7</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Sircar, Jagadish C.</creator><creator>Schwender, Charles F.</creator><creator>Carethers, Mary E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis</title><author>Sircar, Jagadish C. ; Schwender, Charles F. ; Carethers, Mary E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-baf96a6ec9538d4b709049b764ef92ce526df2ef1c1c47941c34575c00c5efe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>5-aminosalicyclic acid</topic><topic>Aminosalicylic Acids - pharmacology</topic><topic>Colitis, Ulcerative - drug therapy</topic><topic>Glycine max</topic><topic>Glycine max - enzymology</topic><topic>Humans</topic><topic>Kinetics</topic><topic>lipoxygenase</topic><topic>Lipoxygenase Inhibitors</topic><topic>Mesalamine</topic><topic>sulfasalazine</topic><topic>Sulfasalazine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sircar, Jagadish C.</creatorcontrib><creatorcontrib>Schwender, Charles F.</creatorcontrib><creatorcontrib>Carethers, Mary E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sircar, Jagadish C.</au><au>Schwender, Charles F.</au><au>Carethers, Mary E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1983</date><risdate>1983</risdate><volume>32</volume><issue>1</issue><spage>170</spage><epage>172</epage><pages>170-172</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>Leukotrienes, hydroperoxyeicosatetraenoic acids (HPETE), and hydroxyeicostetraenoic acids (HETE) are products of arachidonic acid metabolism via the lipoxygenase pathway. They have been shown to be highly potent and stereospecific factors stimulating polymorphonuclear leukocyte (PMNL) migration and enhancing vascular permeability (15). Since sulfasalazine and 5-ASA inhibit the migration of PMNL, it seems possible that sulfasalazine and 5-aminosalicyclic acid (5-ASA) might be working in part through inhibition of the lipoxygenase pathway. To test the above hypothesis, the authors evaluated sulfasalazine and 5-ASA for possible lipoxygenase inhibitor activity.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>6131674</pmid><doi>10.1016/0006-2952(83)90673-1</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2952 |
| ispartof | Biochemical pharmacology, 1983, Vol.32 (1), p.170-172 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 5-aminosalicyclic acid Aminosalicylic Acids - pharmacology Colitis, Ulcerative - drug therapy Glycine max Glycine max - enzymology Humans Kinetics lipoxygenase Lipoxygenase Inhibitors Mesalamine sulfasalazine Sulfasalazine - pharmacology |
| title | Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis |
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