Somatostatin-28 is an hormonally active peptide secreted into hypophysial portal vessel blood
Somatostatin 14 and 28 (SS-14 and SS-28) have been measured in hypophysial portal blood of male Wistar rats. The concentration and total amount of SS released into portal blood were increased 6- to 7-fold by electrical stimulation of the median eminence. On HPLC, only two peaks of immunoreactivity w...
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| Veröffentlicht in: | Brain research 1983-02, Vol.260 (2), p.334-337 |
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| creator | Millar, R.P. Sheward, W.J. Wegener, I. Fink, G. |
| description | Somatostatin 14 and 28 (SS-14 and SS-28) have been measured in hypophysial portal blood of male Wistar rats. The concentration and total amount of SS released into portal blood were increased 6- to 7-fold by electrical stimulation of the median eminence. On HPLC, only two peaks of immunoreactivity were detected in extracts of portal plasma and these peaks corresponded with SS-14 and SS-28, respectively. The amount of SS-28 in portal plasma was, on a molar basis, similar or greater than that of SS-14 and this together with other evidence suggests that SS-28 is an hormonally active peptide. |
| doi_str_mv | 10.1016/0006-8993(83)90692-3 |
| format | Article |
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The concentration and total amount of SS released into portal blood were increased 6- to 7-fold by electrical stimulation of the median eminence. On HPLC, only two peaks of immunoreactivity were detected in extracts of portal plasma and these peaks corresponded with SS-14 and SS-28, respectively. The amount of SS-28 in portal plasma was, on a molar basis, similar or greater than that of SS-14 and this together with other evidence suggests that SS-28 is an hormonally active peptide.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(83)90692-3</identifier><identifier>PMID: 6131728</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; hypophysial portal plasma ; Male ; Median Eminence - physiology ; median eminence stimulation ; Pituitary Gland - innervation ; Pituitary Gland - metabolism ; Protein Precursors - blood ; Rats ; Rats, Inbred Strains ; Somatostatin - blood ; somatostatin 14 ; Somatostatin-28</subject><ispartof>Brain research, 1983-02, Vol.260 (2), p.334-337</ispartof><rights>1983 Elsevier Biomedical Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-207eb1d5ab07586e7cf0d2e98fed4ba6c13291b3807c4317cc9515bf0285ae8f3</citedby><cites>FETCH-LOGICAL-c303t-207eb1d5ab07586e7cf0d2e98fed4ba6c13291b3807c4317cc9515bf0285ae8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(83)90692-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6131728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Millar, R.P.</creatorcontrib><creatorcontrib>Sheward, W.J.</creatorcontrib><creatorcontrib>Wegener, I.</creatorcontrib><creatorcontrib>Fink, G.</creatorcontrib><title>Somatostatin-28 is an hormonally active peptide secreted into hypophysial portal vessel blood</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Somatostatin 14 and 28 (SS-14 and SS-28) have been measured in hypophysial portal blood of male Wistar rats. The concentration and total amount of SS released into portal blood were increased 6- to 7-fold by electrical stimulation of the median eminence. On HPLC, only two peaks of immunoreactivity were detected in extracts of portal plasma and these peaks corresponded with SS-14 and SS-28, respectively. The amount of SS-28 in portal plasma was, on a molar basis, similar or greater than that of SS-14 and this together with other evidence suggests that SS-28 is an hormonally active peptide.</description><subject>Animals</subject><subject>hypophysial portal plasma</subject><subject>Male</subject><subject>Median Eminence - physiology</subject><subject>median eminence stimulation</subject><subject>Pituitary Gland - innervation</subject><subject>Pituitary Gland - metabolism</subject><subject>Protein Precursors - blood</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Somatostatin - blood</subject><subject>somatostatin 14</subject><subject>Somatostatin-28</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVJSR03_6ABnUJ62GYk7Yf2UggmTQuBHpIci9BKs1hhd7WVZIP_feTY-NiehuH9mOEh5AuDbwxYfQsAdSHbVtxI8bWFuuWF-EAWTDa8qHkJZ2RxsnwiFzG-5lWIFs7Jec0Ea7hckD9PftTJx6STmwouqYtUT3Ttw-gnPQw7qk1yW6QzzslZpBFNwISWuil5ut7Nfl7votMDnX1IeWwxRhxoN3hvP5OPvR4iXh7nkrz8uH9e_Swefz_8Wt09FkaASAWHBjtmK91BU8kaG9OD5djKHm3Z6dowwVvWCQmNKfPjxrQVq7oeuKw0yl4syfWhdw7-7wZjUqOLBodBT-g3UUkooWwyh_8ZmaiEyACzsTwYTfAxBuzVHNyow04xUHv8as9W7dkqKdQ7fiVy7OrYv-lGtKfQkXfWvx90zDS2DoOKxuFk0LqAJinr3b8PvAF19pUD</recordid><startdate>19830207</startdate><enddate>19830207</enddate><creator>Millar, R.P.</creator><creator>Sheward, W.J.</creator><creator>Wegener, I.</creator><creator>Fink, G.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19830207</creationdate><title>Somatostatin-28 is an hormonally active peptide secreted into hypophysial portal vessel blood</title><author>Millar, R.P. ; Sheward, W.J. ; Wegener, I. ; Fink, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-207eb1d5ab07586e7cf0d2e98fed4ba6c13291b3807c4317cc9515bf0285ae8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>hypophysial portal plasma</topic><topic>Male</topic><topic>Median Eminence - physiology</topic><topic>median eminence stimulation</topic><topic>Pituitary Gland - innervation</topic><topic>Pituitary Gland - metabolism</topic><topic>Protein Precursors - blood</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Somatostatin - blood</topic><topic>somatostatin 14</topic><topic>Somatostatin-28</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Millar, R.P.</creatorcontrib><creatorcontrib>Sheward, W.J.</creatorcontrib><creatorcontrib>Wegener, I.</creatorcontrib><creatorcontrib>Fink, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Millar, R.P.</au><au>Sheward, W.J.</au><au>Wegener, I.</au><au>Fink, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatostatin-28 is an hormonally active peptide secreted into hypophysial portal vessel blood</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1983-02-07</date><risdate>1983</risdate><volume>260</volume><issue>2</issue><spage>334</spage><epage>337</epage><pages>334-337</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Somatostatin 14 and 28 (SS-14 and SS-28) have been measured in hypophysial portal blood of male Wistar rats. The concentration and total amount of SS released into portal blood were increased 6- to 7-fold by electrical stimulation of the median eminence. On HPLC, only two peaks of immunoreactivity were detected in extracts of portal plasma and these peaks corresponded with SS-14 and SS-28, respectively. The amount of SS-28 in portal plasma was, on a molar basis, similar or greater than that of SS-14 and this together with other evidence suggests that SS-28 is an hormonally active peptide.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6131728</pmid><doi>10.1016/0006-8993(83)90692-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Brain research, 1983-02, Vol.260 (2), p.334-337 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals hypophysial portal plasma Male Median Eminence - physiology median eminence stimulation Pituitary Gland - innervation Pituitary Gland - metabolism Protein Precursors - blood Rats Rats, Inbred Strains Somatostatin - blood somatostatin 14 Somatostatin-28 |
| title | Somatostatin-28 is an hormonally active peptide secreted into hypophysial portal vessel blood |
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