Cytokines in skin lesions of psoriasis
Cytokine levels were compared in aqueous extracts of stratum corneum from psoriatic lesions and normal heel. Samples from heel contained high levels of interleukin-1α (IL-1α) and β measured in immunoassays, although only the IL-1α was biologically active. No other cytokines could be detected in heel...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 1990, Vol.2 (1), p.68-75 |
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| container_title | Cytokine (Philadelphia, Pa.) |
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| creator | Gearing, A.J.H. Fincham, N.J. Bird, C.R. Wadhwa, M. Meager, A. Cartwright, J.E. Camp, R.D.R. |
| description | Cytokine levels were compared in aqueous extracts of stratum corneum from psoriatic lesions and normal heel. Samples from heel contained high levels of interleukin-1α (IL-1α) and β measured in immunoassays, although only the IL-1α was biologically active. No other cytokines could be detected in heel samples. Interleukin-1 (IL-1) levels were dramatically reduced in lesional samples. A neutrophil chemoattractant was found in all lesional extracts, and was demonstrated to be mainly interleukin-8 (IL-8) using a specific neutralizing antiserum. Tumor necrosis factor α (TNF-α) and β (TNF-α), and interferon α (IFN-α) and γ (IFN-γ) were detected in lesional extracts using immunoassays, however, no equivalent biological activities could be detected. Interleukins 2 (IL-2), 4 (IL-4), and 6 (IL-6), granulocyte and granulocyte/macrophage colony stimulating factor (GM-CSF), could not be detected in any samples. IL-8 is therefore the only biologically active cytokine shown in this study to be elevated in psoriatic lesional extracts, and may therefore play a role in the pathogenesis of the disease. |
| doi_str_mv | 10.1016/1043-4666(90)90045-U |
| format | Article |
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Samples from heel contained high levels of interleukin-1α (IL-1α) and β measured in immunoassays, although only the IL-1α was biologically active. No other cytokines could be detected in heel samples. Interleukin-1 (IL-1) levels were dramatically reduced in lesional samples. A neutrophil chemoattractant was found in all lesional extracts, and was demonstrated to be mainly interleukin-8 (IL-8) using a specific neutralizing antiserum. Tumor necrosis factor α (TNF-α) and β (TNF-α), and interferon α (IFN-α) and γ (IFN-γ) were detected in lesional extracts using immunoassays, however, no equivalent biological activities could be detected. Interleukins 2 (IL-2), 4 (IL-4), and 6 (IL-6), granulocyte and granulocyte/macrophage colony stimulating factor (GM-CSF), could not be detected in any samples. IL-8 is therefore the only biologically active cytokine shown in this study to be elevated in psoriatic lesional extracts, and may therefore play a role in the pathogenesis of the disease.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/1043-4666(90)90045-U</identifier><identifier>PMID: 2104215</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Chemotaxis, Leukocyte ; Cytokine ; Cytokines - physiology ; Humans ; Interleukin-1 ; Neutrophils - physiology ; Psoriasis ; Psoriasis - physiopathology ; Skin - physiopathology</subject><ispartof>Cytokine (Philadelphia, Pa.), 1990, Vol.2 (1), p.68-75</ispartof><rights>1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-36a1adfbf049e4225921ee4f361287f1ca3007ecf9f75cda0e05ad9adab5302a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/104346669090045U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2104215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gearing, A.J.H.</creatorcontrib><creatorcontrib>Fincham, N.J.</creatorcontrib><creatorcontrib>Bird, C.R.</creatorcontrib><creatorcontrib>Wadhwa, M.</creatorcontrib><creatorcontrib>Meager, A.</creatorcontrib><creatorcontrib>Cartwright, J.E.</creatorcontrib><creatorcontrib>Camp, R.D.R.</creatorcontrib><title>Cytokines in skin lesions of psoriasis</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>Cytokine levels were compared in aqueous extracts of stratum corneum from psoriatic lesions and normal heel. Samples from heel contained high levels of interleukin-1α (IL-1α) and β measured in immunoassays, although only the IL-1α was biologically active. No other cytokines could be detected in heel samples. Interleukin-1 (IL-1) levels were dramatically reduced in lesional samples. A neutrophil chemoattractant was found in all lesional extracts, and was demonstrated to be mainly interleukin-8 (IL-8) using a specific neutralizing antiserum. Tumor necrosis factor α (TNF-α) and β (TNF-α), and interferon α (IFN-α) and γ (IFN-γ) were detected in lesional extracts using immunoassays, however, no equivalent biological activities could be detected. Interleukins 2 (IL-2), 4 (IL-4), and 6 (IL-6), granulocyte and granulocyte/macrophage colony stimulating factor (GM-CSF), could not be detected in any samples. IL-8 is therefore the only biologically active cytokine shown in this study to be elevated in psoriatic lesional extracts, and may therefore play a role in the pathogenesis of the disease.</description><subject>Chemotaxis, Leukocyte</subject><subject>Cytokine</subject><subject>Cytokines - physiology</subject><subject>Humans</subject><subject>Interleukin-1</subject><subject>Neutrophils - physiology</subject><subject>Psoriasis</subject><subject>Psoriasis - physiopathology</subject><subject>Skin - physiopathology</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKw0AUhgdRqlbfQCGroovomUuSzkaQ4g0Kbux6mE7OwGiaqXNaoW9vYoNLXZ0f_suBj7ELDjcceHnLQclclWV5peFaA6giXxywEw66zAGEPOz1EDlmp0TvAKBlVY3YSHSO4MUJm8x2m_gRWqQstBl1KmuQQmwpiz5bU0zBUqAzduRtQ3g-3DFbPD68zZ7z-evTy-x-njsJcpPL0nJb-6UHpVEJUWjBEZWXJRfTynNnJUCFzmtfFa62gFDYWtvaLgsJwsoxm-x31yl-bpE2ZhXIYdPYFuOWzBSkVkKKf4O8qGQ55boLqn3QpUiU0Jt1CiubdoaD6TmaHpLpIRkN5oejWXS1y2F_u1xh_VsawHX-3d7HjsZXwGTIBWwd1iGh25g6hr8ffAPyhICm</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Gearing, A.J.H.</creator><creator>Fincham, N.J.</creator><creator>Bird, C.R.</creator><creator>Wadhwa, M.</creator><creator>Meager, A.</creator><creator>Cartwright, J.E.</creator><creator>Camp, R.D.R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Cytokines in skin lesions of psoriasis</title><author>Gearing, A.J.H. ; Fincham, N.J. ; Bird, C.R. ; Wadhwa, M. ; Meager, A. ; Cartwright, J.E. ; Camp, R.D.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-36a1adfbf049e4225921ee4f361287f1ca3007ecf9f75cda0e05ad9adab5302a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Chemotaxis, Leukocyte</topic><topic>Cytokine</topic><topic>Cytokines - physiology</topic><topic>Humans</topic><topic>Interleukin-1</topic><topic>Neutrophils - physiology</topic><topic>Psoriasis</topic><topic>Psoriasis - physiopathology</topic><topic>Skin - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gearing, A.J.H.</creatorcontrib><creatorcontrib>Fincham, N.J.</creatorcontrib><creatorcontrib>Bird, C.R.</creatorcontrib><creatorcontrib>Wadhwa, M.</creatorcontrib><creatorcontrib>Meager, A.</creatorcontrib><creatorcontrib>Cartwright, J.E.</creatorcontrib><creatorcontrib>Camp, R.D.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gearing, A.J.H.</au><au>Fincham, N.J.</au><au>Bird, C.R.</au><au>Wadhwa, M.</au><au>Meager, A.</au><au>Cartwright, J.E.</au><au>Camp, R.D.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokines in skin lesions of psoriasis</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>1990</date><risdate>1990</risdate><volume>2</volume><issue>1</issue><spage>68</spage><epage>75</epage><pages>68-75</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>Cytokine levels were compared in aqueous extracts of stratum corneum from psoriatic lesions and normal heel. Samples from heel contained high levels of interleukin-1α (IL-1α) and β measured in immunoassays, although only the IL-1α was biologically active. No other cytokines could be detected in heel samples. Interleukin-1 (IL-1) levels were dramatically reduced in lesional samples. A neutrophil chemoattractant was found in all lesional extracts, and was demonstrated to be mainly interleukin-8 (IL-8) using a specific neutralizing antiserum. Tumor necrosis factor α (TNF-α) and β (TNF-α), and interferon α (IFN-α) and γ (IFN-γ) were detected in lesional extracts using immunoassays, however, no equivalent biological activities could be detected. Interleukins 2 (IL-2), 4 (IL-4), and 6 (IL-6), granulocyte and granulocyte/macrophage colony stimulating factor (GM-CSF), could not be detected in any samples. IL-8 is therefore the only biologically active cytokine shown in this study to be elevated in psoriatic lesional extracts, and may therefore play a role in the pathogenesis of the disease.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>2104215</pmid><doi>10.1016/1043-4666(90)90045-U</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1043-4666 |
| ispartof | Cytokine (Philadelphia, Pa.), 1990, Vol.2 (1), p.68-75 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Chemotaxis, Leukocyte Cytokine Cytokines - physiology Humans Interleukin-1 Neutrophils - physiology Psoriasis Psoriasis - physiopathology Skin - physiopathology |
| title | Cytokines in skin lesions of psoriasis |
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