The value of flumazenil in the reversal of midazolam‐induced sedation for upper gastrointestinal endoscopy
SUMMARY Fifty patients who underwent diagnostic upper gastrointestinal endoscopy after midazolam sedation were randomized to receive (after completion of the examination) either the benzodiazepine receptor antagonist flumazenil or an identical‐looking placebo. The speed of recovery from sedation was...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 1990-02, Vol.4 (1), p.35-42 |
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| container_title | Alimentary pharmacology & therapeutics |
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| creator | DUNK, A. A. NORTON, A. C. HUDSON, M. DUNDAS, C. R. MOWAT, N. ASHLEY G. |
| description | SUMMARY
Fifty patients who underwent diagnostic upper gastrointestinal endoscopy after midazolam sedation were randomized to receive (after completion of the examination) either the benzodiazepine receptor antagonist flumazenil or an identical‐looking placebo. The speed of recovery from sedation was assessed by reaction time testing, measurement of critical flicker fusion frequency, and the semi‐quantitative SOCA scoring system. Measurements were made up to 6 h post examination in all subjects, and at 12 and 24 h in all in‐patients (n= 20). Flumazenil‐treated patients were significantly more alert than those who received placebo at 10 min, 30 min, 1 h and 2 h (P < 0.001 in all instances). Thereafter the two groups were similar. There was no evidence of recurrence of sedation in flumazenil‐treated patients, nor did this drug adversely affect the period of anterograde amnesia between the administration of midazolam and flumazenil. |
| doi_str_mv | 10.1111/j.1365-2036.1990.tb00446.x |
| format | Article |
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Fifty patients who underwent diagnostic upper gastrointestinal endoscopy after midazolam sedation were randomized to receive (after completion of the examination) either the benzodiazepine receptor antagonist flumazenil or an identical‐looking placebo. The speed of recovery from sedation was assessed by reaction time testing, measurement of critical flicker fusion frequency, and the semi‐quantitative SOCA scoring system. Measurements were made up to 6 h post examination in all subjects, and at 12 and 24 h in all in‐patients (n= 20). Flumazenil‐treated patients were significantly more alert than those who received placebo at 10 min, 30 min, 1 h and 2 h (P < 0.001 in all instances). Thereafter the two groups were similar. There was no evidence of recurrence of sedation in flumazenil‐treated patients, nor did this drug adversely affect the period of anterograde amnesia between the administration of midazolam and flumazenil.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.1990.tb00446.x</identifier><identifier>PMID: 2104071</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Double-Blind Method ; Endoscopy, Gastrointestinal ; Female ; Flicker Fusion - drug effects ; Flumazenil - pharmacology ; Humans ; Male ; Midazolam - antagonists & inhibitors ; Middle Aged ; Premedication</subject><ispartof>Alimentary pharmacology & therapeutics, 1990-02, Vol.4 (1), p.35-42</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4345-74f68665b7cab750bf4091d31f951271621495d1f8a0b24709f4800474e9acdf3</citedby><cites>FETCH-LOGICAL-c4345-74f68665b7cab750bf4091d31f951271621495d1f8a0b24709f4800474e9acdf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.1990.tb00446.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.1990.tb00446.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2104071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DUNK, A. A.</creatorcontrib><creatorcontrib>NORTON, A. C.</creatorcontrib><creatorcontrib>HUDSON, M.</creatorcontrib><creatorcontrib>DUNDAS, C. R.</creatorcontrib><creatorcontrib>MOWAT, N. ASHLEY G.</creatorcontrib><title>The value of flumazenil in the reversal of midazolam‐induced sedation for upper gastrointestinal endoscopy</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>SUMMARY
Fifty patients who underwent diagnostic upper gastrointestinal endoscopy after midazolam sedation were randomized to receive (after completion of the examination) either the benzodiazepine receptor antagonist flumazenil or an identical‐looking placebo. The speed of recovery from sedation was assessed by reaction time testing, measurement of critical flicker fusion frequency, and the semi‐quantitative SOCA scoring system. Measurements were made up to 6 h post examination in all subjects, and at 12 and 24 h in all in‐patients (n= 20). Flumazenil‐treated patients were significantly more alert than those who received placebo at 10 min, 30 min, 1 h and 2 h (P < 0.001 in all instances). Thereafter the two groups were similar. There was no evidence of recurrence of sedation in flumazenil‐treated patients, nor did this drug adversely affect the period of anterograde amnesia between the administration of midazolam and flumazenil.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Double-Blind Method</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Female</subject><subject>Flicker Fusion - drug effects</subject><subject>Flumazenil - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Midazolam - antagonists & inhibitors</subject><subject>Middle Aged</subject><subject>Premedication</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM9u1DAQhy0EKkvhEZAsDtwSxrHjxEgcqop_UiU4LGfLicfglRMHOyndnngEnpEnIdGuemcuc_jmNzP6CHnFoGRrvTmUjMu6qIDLkikF5dwBCCHLu0dk94Aekx1UUhVVy_hT8iznAwDIBqoLclExENCwHQn7H0hvTViQRkddWAZzj6MP1I90XlHCW0zZhI0O3pr7GMzw9_cfP9qlR0szWjP7OFIXE12mCRP9bvKcoh9nzLMf1yiONuY-Tsfn5IkzIeOLc78k3z68319_Km6-fPx8fXVT9IKLumiEk62Uddf0pmtq6JwAxSxnTtWsapismFC1Za410FWiAeVEuwpoBCrTW8cvyevT3inFn8v6hh587jEEM2Jcsm6Bt4orvg6-PQ32Keac0Okp-cGko2agN9X6oDefevOpN9X6rFrfreGX5ytLN6B9iJ7drvzdif_yAY__sVlffd3zmv8DlaeQQQ</recordid><startdate>199002</startdate><enddate>199002</enddate><creator>DUNK, A. A.</creator><creator>NORTON, A. C.</creator><creator>HUDSON, M.</creator><creator>DUNDAS, C. R.</creator><creator>MOWAT, N. ASHLEY G.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199002</creationdate><title>The value of flumazenil in the reversal of midazolam‐induced sedation for upper gastrointestinal endoscopy</title><author>DUNK, A. A. ; NORTON, A. C. ; HUDSON, M. ; DUNDAS, C. R. ; MOWAT, N. ASHLEY G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4345-74f68665b7cab750bf4091d31f951271621495d1f8a0b24709f4800474e9acdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Double-Blind Method</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Female</topic><topic>Flicker Fusion - drug effects</topic><topic>Flumazenil - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Midazolam - antagonists & inhibitors</topic><topic>Middle Aged</topic><topic>Premedication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DUNK, A. A.</creatorcontrib><creatorcontrib>NORTON, A. C.</creatorcontrib><creatorcontrib>HUDSON, M.</creatorcontrib><creatorcontrib>DUNDAS, C. R.</creatorcontrib><creatorcontrib>MOWAT, N. ASHLEY G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUNK, A. A.</au><au>NORTON, A. C.</au><au>HUDSON, M.</au><au>DUNDAS, C. R.</au><au>MOWAT, N. ASHLEY G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of flumazenil in the reversal of midazolam‐induced sedation for upper gastrointestinal endoscopy</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>1990-02</date><risdate>1990</risdate><volume>4</volume><issue>1</issue><spage>35</spage><epage>42</epage><pages>35-42</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>SUMMARY
Fifty patients who underwent diagnostic upper gastrointestinal endoscopy after midazolam sedation were randomized to receive (after completion of the examination) either the benzodiazepine receptor antagonist flumazenil or an identical‐looking placebo. The speed of recovery from sedation was assessed by reaction time testing, measurement of critical flicker fusion frequency, and the semi‐quantitative SOCA scoring system. Measurements were made up to 6 h post examination in all subjects, and at 12 and 24 h in all in‐patients (n= 20). Flumazenil‐treated patients were significantly more alert than those who received placebo at 10 min, 30 min, 1 h and 2 h (P < 0.001 in all instances). Thereafter the two groups were similar. There was no evidence of recurrence of sedation in flumazenil‐treated patients, nor did this drug adversely affect the period of anterograde amnesia between the administration of midazolam and flumazenil.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2104071</pmid><doi>10.1111/j.1365-2036.1990.tb00446.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 1990-02, Vol.4 (1), p.35-42 |
| issn | 0269-2813 1365-2036 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Double-Blind Method Endoscopy, Gastrointestinal Female Flicker Fusion - drug effects Flumazenil - pharmacology Humans Male Midazolam - antagonists & inhibitors Middle Aged Premedication |
| title | The value of flumazenil in the reversal of midazolam‐induced sedation for upper gastrointestinal endoscopy |
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