Hypoxia-induced decrease of brain acetylcholine release detected by microdialysis
The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20...
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| Veröffentlicht in: | Neuroreport 1990-11, Vol.1 (3), p.197-199 |
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| creator | Chleide, Eric Ishikawa, Koichi |
| description | The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxia, the ACh levels were decreased to 62% and 44% of the control value with 10% and 5% oxygen, respectively. The data confirmed the high sensitivity of the striatal cholinergic system to hypoxia. The results are discussed in relation to the hypothesis that disruption of Ca homeostasis may underlie the hypoxia-induced deficits in ACh release. |
| doi_str_mv | 10.1097/00001756-199011000-00005 |
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The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxia, the ACh levels were decreased to 62% and 44% of the control value with 10% and 5% oxygen, respectively. The data confirmed the high sensitivity of the striatal cholinergic system to hypoxia. The results are discussed in relation to the hypothesis that disruption of Ca homeostasis may underlie the hypoxia-induced deficits in ACh release.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Brain Chemistry - physiology</subject><subject>Calcium - metabolism</subject><subject>Corpus Striatum - metabolism</subject><subject>Dialysis</subject><subject>Hypoxia - metabolism</subject><subject>Male</subject><subject>Microchemistry</subject><subject>Perfusion</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1LAzEQDaLUWv0Jwp68rSabj02OImoFQQQFbyFNZmk07dZkl7r_3vTD3pzLMPPemxneIFQQfE2wqm9wDlJzURKlMCG5KjctfoTGhNW05Fx-HKMxVlyVTAl-is5S-syMzJYjNKpIpaTEY_Q6HVbtjzelX7regisc2AgmQdE2xSwavyyMhW4Idt4Gv4QiQtjCDjqwXRbMhmLhbWydN2FIPp2jk8aEBBf7PEHvD_dvd9Py-eXx6e72ubSUCl7SWlCmOKuYaBTjQoICawlz0lIhKg5GKcoNE4KBZYQI5pQTQoCrXA1NTSfoajd3FdvvHlKnFz5ZCMEsoe2TlphKqTDORLkj5iNTitDoVfQLEwdNsN64qf_c1Ac3ty2epZf7Hf1sAe4g3NuXcbbD123oIKav0K8h6jmY0M31f0-iv7dHfyU</recordid><startdate>199011</startdate><enddate>199011</enddate><creator>Chleide, Eric</creator><creator>Ishikawa, Koichi</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199011</creationdate><title>Hypoxia-induced decrease of brain acetylcholine release detected by microdialysis</title><author>Chleide, Eric ; Ishikawa, Koichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3365-37634954246f94568e9ecc14d8c36625ea9935a4664ec41164d9d666ed2d7ef73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Brain Chemistry - physiology</topic><topic>Calcium - metabolism</topic><topic>Corpus Striatum - metabolism</topic><topic>Dialysis</topic><topic>Hypoxia - metabolism</topic><topic>Male</topic><topic>Microchemistry</topic><topic>Perfusion</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chleide, Eric</creatorcontrib><creatorcontrib>Ishikawa, Koichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chleide, Eric</au><au>Ishikawa, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxia-induced decrease of brain acetylcholine release detected by microdialysis</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1990-11</date><risdate>1990</risdate><volume>1</volume><issue>3</issue><spage>197</spage><epage>199</epage><pages>197-199</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. 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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acetylcholine - metabolism Animals Brain Chemistry - physiology Calcium - metabolism Corpus Striatum - metabolism Dialysis Hypoxia - metabolism Male Microchemistry Perfusion Rats Rats, Inbred Strains |
| title | Hypoxia-induced decrease of brain acetylcholine release detected by microdialysis |
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